| Transcription Factor FOSL1 Enhances Drug Resistance of Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15. | Transcription Factor FOSL1 Enhances Drug Resistance of Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15.
Li L, Wang N, Xiong Y, Guo G, Zhu M, Gu Y. | 08/6/2022 |
| PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner. | PEA-15 engages in allosteric interactions using a common scaffold in a phosphorylation-dependent manner.
Ikedife J, He J, Wei Y., Free PMC Article | 03/5/2022 |
| Proteomics analysis identifies PEA-15 as an endosomal phosphoprotein that regulates alpha5beta1 integrin endocytosis. | Proteomics analysis identifies PEA-15 as an endosomal phosphoprotein that regulates α5β1 integrin endocytosis.
Caliva MJ, Yang WS, Young-Robbins S, Zhou M, Yoon H, Matter ML, Grimes ML, Conrads T, Ramos JW., Free PMC Article | 01/1/2022 |
| Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression. | Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression.
Park J, Tacam MJ, Chauhan G, Cohen EN, Gagliardi M, Iles LR, Ueno NT, Battula VL, Sohn YK, Wang X, Kim HS, Krishnamurthy S, Fowlkes NW, Green MM, Bartholomeusz GA, Tripathy D, Reuben JM, Bartholomeusz C., Free PMC Article | 08/21/2021 |
| ZNF703 promotes tumor progression in ovarian cancer by interacting with HE4 and epigenetically regulating PEA15. | ZNF703 promotes tumor progression in ovarian cancer by interacting with HE4 and epigenetically regulating PEA15.
Wang S, Wang C, Hu Y, Li X, Jin S, Liu O, Gou R, Zhuang Y, Guo Q, Nie X, Zhu L, Liu J, Lin B., Free PMC Article | 08/7/2021 |
| Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin. | Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin.
Dilruba S, Grondana A, Schiedel AC, Ueno NT, Bartholomeusz C, Cinatl J Jr, McLaughlin KM, Wass MN, Michaelis M, Kalayda GV., Free PMC Article | 03/6/2021 |
| This study identified EA15, MIR22, and LINC00472 may serve as the potential diagnostic markers of diabetic nephropathy. | EA15, MIR22, LINC00472 as diagnostic markers for diabetic kidney disease.
Wang YZ, Zhu DY, Xie XM, Ding M, Wang YL, Sun LL, Zhang N, Shen E, Wang XX. | 04/18/2020 |
| Study results indicated that PEA15 expression was associated with clinicopathology and prognosis in gastric cancer and was regulated by AKT to participate in cisplatin resistance, indicating that it may be a potential target for overcoming cisplatin resistance in the treatment of gastric cancer. | PEA‑15 contributes to the clinicopathology and AKT‑regulated cisplatin resistance in gastric cancer.
Jiang X, Zhang C, Li W, Jiang D, Wei Z, Lv M, Xie X, Sun X. | 03/16/2019 |
| Data suggest that PED has a prominent role in HCC biology. It acts particularly on promoting cell migration and confers resistance to sorafenib treatment. | Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.
Quintavalle C, Hindupur SK, Quagliata L, Pallante P, Nigro C, Condorelli G, Andersen JB, Tagscherer KE, Roth W, Beguinot F, Heim MH, Ng CKY, Piscuoglio S, Matter MS., Free PMC Article | 07/7/2018 |
| PP4 regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival. | The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells.
Mohammed HN, Pickard MR, Mourtada-Maarabouni M. | 12/2/2017 |
| PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance. | Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells.
Huang KC, Yang J, Ng MC, Ng SK, Welch WR, Muto MG, Berkowitz RS, Ng SW., Free PMC Article | 08/5/2017 |
| Data suggest the role of the phospholipase C epsilon-Protein kinase D-PEA15 protein-ribosomal S6 kinase-IkappaB-NF-kappa B pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon. | Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.
Wakita M, Edamatsu H, Li M, Emi A, Kitazawa S, Kataoka T., Free PMC Article | 12/17/2016 |
| Integrin alpha5beta1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. | Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma.
Renner G, Janouskova H, Noulet F, Koenig V, Guerin E, Bär S, Nuesch J, Rechenmacher F, Neubauer S, Kessler H, Blandin AF, Choulier L, Etienne-Selloum N, Lehmann M, Lelong-Rebel I, Martin S, Dontenwill M., Free PMC Article | 12/17/2016 |
| High PED expression is associated with esophageal carcinoma. | Expression and significance of CDC25B, PED/PEA-15 in esophageal carcinoma.
Wang M, Zhu XY, Wang L, Lin Y. | 01/16/2016 |
| The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype. | Downregulation of PEA-15 reverses G1 arrest, and nuclear and chromatin changes of senescence phenotype via pErk1/2 translocation to nuclei.
Lee YY, Kim HS, Lim IK. | 12/26/2015 |
| Latent HCMV infection of CD34 + cells protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway. | Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway.
Poole E, Lau JCH, Sinclair J., Free PMC Article | 12/19/2015 |
| New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases. | Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.
Greig FH, Nixon GF., Free PMC Article | 10/10/2015 |
| PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism | PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1.
Fiory F, Parrillo L, Raciti GA, Zatterale F, Nigro C, Mirra P, Falco R, Ulianich L, Di Jeso B, Formisano P, Miele C, Beguinot F., Free PMC Article | 10/3/2015 |
| Omi/HtrA2 overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 pro-apoptotic marker in the various hepatocellular carcinoma cell lines | Omi/HtrA2 pro-apoptotic marker differs in various hepatocellular carcinoma cell lines owing to ped/pea-15 expression level.
Xu Z, Chen Y, Xu G, Peng C, Liu E, Li Y, Niu J, Li C. | 08/15/2015 |
| Results suggest that neurochemical adaptations of brain FADD, as well as its interaction with PEA-15, could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression | FADD adaptor and PEA-15/ERK1/2 partners in major depression and schizophrenia postmortem brains: basal contents and effects of psychotropic treatments.
García-Fuster MJ, Díez-Alarcia R, Ferrer-Alcón M, La Harpe R, Meana JJ, García-Sevilla JA. | 06/20/2015 |
| Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) influences dephosphorylation of epidermal growth factor receptor (EGFR) via extracellular signal-regulated kinases ERK1/2 sequestration in the cytoplasm. | PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells.
Shin M, Lee KE, Yang EG, Jeon H, Song HK. | 06/20/2015 |
| Tumor suppressor PEA15 is a regulator of genome integrity and is an integral component of the DNA damage response pathway. | PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.
Nagarajan A, Dogra SK, Liu AY, Green MR, Wajapeyee N., Free PMC Article | 10/4/2014 |
| Up-regulated chaperone-mediated autophagy activity characteristic of most types of cancer cell enhances oncogenesis by shifting the balance of PED function toward tumor promotion. | Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells.
Quintavalle C, Di Costanzo S, Zanca C, Tasset I, Fraldi A, Incoronato M, Mirabelli P, Monti M, Ballabio A, Pucci P, Cuervo AM, Condorelli G., Free PMC Article | 09/6/2014 |
| Our findings highlight the importance of pPEA-15 as a promising target for improving the efficacy of paclitaxel-based therapy in ovarian cancer. | Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.
Xie X, Bartholomeusz C, Ahmed AA, Kazansky A, Diao L, Baggerly KA, Hortobagyi GN, Ueno NT., Free PMC Article | 03/1/2014 |
| PEA-15 binding protects ERK2 from dephosphorylation, thus setting the stage for immediate ERK activity upon its release from the PEA-15 inhibitory complex | Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Mace PD, Wallez Y, Egger MF, Dobaczewska MK, Robinson H, Pasquale EB, Riedl SJ., Free PMC Article | 10/26/2013 |