| Complement factor H attenuates TNF-alpha-induced inflammation by upregulating EIF3C in rheumatoid arthritis. | Complement factor H attenuates TNF-α-induced inflammation by upregulating EIF3C in rheumatoid arthritis.
Jia Y, Feng B, Ji X, Tian X, Zhao L, Zhou J, Zhang W, Li M, Fei Y, Wu X., Free PMC Article | 11/28/2023 |
| circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA. | circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA.
Ding L, Wang R, Zheng Q, Shen D, Wang H, Lu Z, Luo W, Xie H, Ren L, Jiang M, Yu C, Zhou Z, Lin Y, Lu H, Xue D, Su W, Xia L, Neuhaus J, Cheng S, Li G., Free PMC Article | 06/11/2022 |
| Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism. | Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
Singh CR, Glineburg MR, Moore C, Tani N, Jaiswal R, Zou Y, Aube E, Gillaspie S, Thornton M, Cecil A, Hilgers M, Takasu A, Asano I, Asano M, Escalante CR, Nakamura A, Todd PK, Asano K., Free PMC Article | 02/12/2022 |
| ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C. | ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C.
Liu H, Qin Y, Zhou N, Ma D, Wang Y., Free PMC Article | 09/18/2021 |
| Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells. | Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells.
Wen F, Wu ZY, Nie L, Zhang QZ, Qin YK, Zhou ZL, Wu JJ, Zhao X, Tan J, Sawmiller D, Zi D., Free PMC Article | 09/19/2020 |
| circ_0067934 promotes cervical cancer progression via miR-545/EIF3C axis. | Overexpressed circ_0067934 acts as an oncogene to facilitate cervical cancer progression via the miR-545/EIF3C axis.
Hu C, Wang Y, Li A, Zhang J, Xue F, Zhu L. | 04/11/2020 |
| eIF3C expression was upregulated in renal cell carcinoma (RCC) tissues and cell lines. Depletion of eIF3C reduced tumor cell proliferation and arrested them at the G1 stage, thus promoting their apoptosis in vitro. Depletion of eIF3C also inhibited the formation and growth of tumor cell xenografts in nude mice. Study demonstrated that upregulated eIF3C expression contributed to the development and progression of RCC. | Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma.
Fan M, Wang K, Wei X, Yao H, Chen Z, He X. | 04/4/2020 |
| Whereas the eIF3c knockdown reduces it, downregulation of eIF3k or eIF3l increases mRNA recruitment, suggesting that the latter subunits possess a regulatory potential. Altogether this study provides new insights into the role of human eIF3 in the initial assembly steps of the translational machinery | Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.
Herrmannová A, Prilepskaja T, Wagner S, Šikrová D, Zeman J, Poncová K, Valášek LS., Free PMC Article | 03/21/2020 |
| EIF3C overexpression was correlated to age and tumor stage in prostate cancer patients and indicated poor survival. The proliferation, migration, and invasiveness of PC3 cells were all inhibited after EIF3C knockdown. Phosphorylation level of PI3K and Akt and total NF-kappaB and Myc decreased after EIF3C knockdown. Therefore, EIF3C at least partially regulates the activity of PI3K/Akt/NF-kappaB signaling pathway in PC3... | The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer.
Hu J, Luo H, Xu Y, Luo G, Xu S, Zhu J, Song D, Sun Z, Kuang Y. | 07/13/2019 |
| In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity. | Decreasing Eukaryotic Initiation Factor 3C (EIF3C) Suppresses Proliferation and Stimulates Apoptosis in Breast Cancer Cell Lines Through Mammalian Target of Rapamycin (mTOR) Pathway.
Zhao W, Li X, Wang J, Wang C, Jia Y, Yuan S, Huang Y, Shi Y, Tong Z., Free PMC Article | 12/16/2017 |
| High eIF3c expression is positively associated with KRAS. | Transcriptomic analyses of RNA-binding proteins reveal eIF3c promotes cell proliferation in hepatocellular carcinoma.
Li T, Li S, Chen D, Chen B, Yu T, Zhao F, Wang Q, Yao M, Huang S, Chen Z, He X., Free PMC Article | 09/16/2017 |
| These findings suggest that eIF3c is overexpressed in human gliomas and essential for their proliferation and survival. | Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma.
Hao J, Wang Z, Wang Y, Liang Z, Zhang X, Zhao Z, Jiao B. | 02/6/2016 |
| eIF3a and eIF3c control abundance and assembly of the entire eIF3 and thus represent its crucial scaffolding elements critically required for formation of preinitiation complexes. | Functional and biochemical characterization of human eukaryotic translation initiation factor 3 in living cells.
Wagner S, Herrmannová A, Malík R, Peclinovská L, Valášek LS., Free PMC Article | 10/11/2014 |
| eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. | Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome.
Villa N, Do A, Hershey JW, Fraser CS., Free PMC Article | 01/25/2014 |
| Collectively, eIF3c deletion effectively reduced the survival of colon cancer cells and could be used as a therapeutic tool for colon cancer therapy. | Effect of siRNA-mediated knockdown of eIF3c gene on survival of colon cancer cells.
Song N, Wang Y, Gu XD, Chen ZY, Shi LB., Free PMC Article | 01/18/2014 |
| These results indicate that the interaction between Hsp90 and eIF3c may play an important role in hepatitis C virus internal ribosome entry site-mediated translation. | The interaction between human initiation factor eIF3 subunit c and heat-shock protein 90: a necessary factor for translation mediated by the hepatitis C virus internal ribosome entry site.
Ujino S, Nishitsuji H, Sugiyama R, Suzuki H, Hishiki T, Sugiyama K, Shimotohno K, Takaku H. | 05/5/2012 |