| Natural Selection of H5N1 Avian Influenza A Viruses with Increased PA-X and NS1 Shutoff Activity. | Natural Selection of H5N1 Avian Influenza A Viruses with Increased PA-X and NS1 Shutoff Activity.
Nogales A, Villamayor L, Utrilla-Trigo S, Ortego J, Martinez-Sobrido L, DeDiego ML., Free PMC Article | 02/19/2022 |
| The N-terminal residual arginine(19) of influenza A virus NS1 protein is required for its nuclear localization and RNA binding. | The N-terminal residual arginine(19) of influenza A virus NS1 protein is required for its nuclear localization and RNA binding.
Wang X, Lin L, Yu Y, Yan Y, Ojha NK, Zhou J. | 07/17/2021 |
| Differential modulation of innate immune responses in human primary cells by influenza A viruses carrying human or avian NS1 protein has been reported. | Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1.
Monteagudo PL, Muñoz-Moreno R, Fribourg M, Potla U, Mena I, Marjanovic N, Hartmann BM, Sealfon SC, García-Sastre A, Ramos I, Fernández-Sesma A., Free PMC Article | 06/13/2020 |
| study demonstrated that the amino acid at positions 55, 66, and 133 of NS1 play an important role in the ability of H5N1 influenza viruses to dampen the host IFN response | Three amino acid substitutions in the NS1 protein change the virus replication of H5N1 influenza virus in human cells.
Li J, Zhang K, Chen Q, Zhang X, Sun Y, Bi Y, Zhang S, Gu J, Li J, Liu D, Liu W, Zhou J. | 06/16/2018 |
| ANXA2 interacts with NS1 and ANXA2 expression increases highly pathogenic H5N1 avian influenza virus replication. | Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus.
Ma Y, Sun J, Gu L, Bao H, Zhao Y, Shi L, Yao W, Tian G, Wang X, Chen H., Free PMC Article | 05/5/2018 |
| Studies showed that the replacement of the 42nd residue of NS1 has a direct impact on the binding to dsRNA, so that the 42nd residue should be responsible for the high pathogenicity of H5N1. The structural models also suggested that the replacement causes structural change within the RNA-binding domain , leading to the change in the dsRNA-binding affinity. | Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1.
Kato YS, Fukui K, Suzuki K. | 12/17/2016 |
| analysis yielded chicken gga-miR-1658* as the potential miRNA which is targeting the NS1 gene of H5N1 genome | In-silico search of virus-specific host microRNAs regulating avian influenza virus NS1 expression.
Asaf VN, Kumar A, Raut AA, Bhatia S, Mishra A. | 04/23/2016 |
| D120 and R195 of H5N1 influenza virus NS1 were crucial for the binding to host NOLC1. | Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein.
Zhu CY, Zheng FL, She XS, Zhao D, Gu Y, Duan YT, Chang AK, Liu HS. | 03/12/2016 |
| This is the first report to elucidate the novel function of NS1--binding protein collaborating with viral protein NS1 in modulation of host cell physiology. In addition, an alternative role of adaptor protein CRKL in association with NS1 and NS1-BP during influenza A virus infection is demonstrated. | NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL.
Miyazaki M, Nishihara H, Hasegawa H, Tashiro M, Wang L, Kimura T, Tanino M, Tsuda M, Tanaka S. | 04/5/2014 |
| H5N1 viral NS1 interacts with host NOLC1 protein. | Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1.
Zhu C, Zheng F, Sun T, Duan Y, Cao J, Feng H, Shang L, Zhu Y, Liu H., Free PMC Article | 09/7/2013 |
| The PDZ and p85beta-binding domains of the NS1 protein are important for the virulence of H5N1 influenza A virus. | Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus.
Fan S, Macken CA, Li C, Ozawa M, Goto H, Iswahyudi NF, Nidom CA, Chen H, Neumann G, Kawaoka Y., Free PMC Article | 07/13/2013 |
| Findings indicate that the heterologous interactions between non-structural protein 1 (NS1) proteins from different influenza A virus subtypes/strains may be a common event during co-infection. | Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains.
Li W, Zhang H, Wang G, Zhang C, Zeng X, Liu H, Chen X, Xu Y, Li K. | 11/3/2012 |
| Expression of NS1 in trans rescues HA protein and mRNA expression from NS1-truncated viruses. | Attenuated influenza virus construct with enhanced hemagglutinin protein expression.
Maamary J, Pica N, Belicha-Villanueva A, Chou YY, Krammer F, Gao Q, García-Sastre A, Palese P., Free PMC Article | 06/23/2012 |
| The high pathogenic strains of the avian influenza H5N1 virus isolated in Kazakhstan have NS of different genotypes. The influenza virus strains isolated in 2005 is of NS1E Qinghai genotype. | Molecular and genetic analysis of NS gene from high pathogenic strains of the avian influenza (H5N1) virus isolated in Kazakhstan.
Chervyakova OV, Strochkov VM, Sultankulova KT, Sandybayev NT, Zaitsev VL, Mamadaliyev SM. | 06/4/2011 |
| NS1 of H5N1 was an effective inhibitor of cellular pre-mRNA polyadenylation in A549 cells, unlike NS1 of H5N2 and H1N1/2009 | Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation.
Kainov DE, Müller KH, Theisen LL, Anastasina M, Kaloinen M, Muller CP., Free PMC Article | 05/7/2011 |
| Data suggest that NS1 can directly interfere with IFN signaling to enhance viral replication. | Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling.
Jia D, Rahbar R, Chan RW, Lee SM, Chan MC, Wang BX, Baker DP, Sun B, Peiris JS, Nicholls JM, Fish EN., Free PMC Article | 04/30/2011 |
| Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein. | Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein.
Zielecki F, Semmler I, Kalthoff D, Voss D, Mauel S, Gruber AD, Beer M, Wolff T., Free PMC Article | 01/15/2011 |
| found that the D92E mutation eliminated NS1's repressive effect on IFN induction, while the 5-aa deletion resulted in enhanced resistance to TNFalpha responses. | Effects of NS1 variants of H5N1 influenza virus on interferon induction, TNFalpha response and p53 activity.
Li W, Wang G, Zhang H, Xin G, Zhang D, Zeng J, Chen X, Xu Y, Cui Y, Li K., Free PMC Article | 06/14/2010 |