| Pathogenic Roles for RNASET2 in Clear Cell Renal Cell Carcinoma. | Pathogenic Roles for RNASET2 in Clear Cell Renal Cell Carcinoma.
Peak T, Tian Y, Patel A, Shaw T, Obermayer A, Laborde J, Kim Y, Johnson J, Stewart P, Fang B, Teer JK, Koomen J, Berglund A, Marchion D, Francis N, Echevarria PR, Dhillon J, Clark N, Chang A, Sexton W, Zemp L, Chahoud J, Wang L, Manley B. | 08/12/2024 |
| Systematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma. | Systematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma.
Liu Y, Zhang Z, Xi P, Chen R, Cheng X, Liu J, Zhu Q, Nie Y, Sun T, Gong B, Wang S., Free PMC Article | 09/13/2023 |
| HIF2alpha-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma. | HIF2α-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma.
Quan Y, Dai J, Zhou S, Zhao L, Jin L, Long Y, Liu S, Hu Y, Liu Y, Zhao J, Ding Z., Free PMC Article | 04/7/2023 |
| A potential role of human RNASET2 overexpression in the pathogenesis of Graves' disease. | A potential role of human RNASET2 overexpression in the pathogenesis of Graves' disease.
Gallo D, De Vito A, Roncoroni R, Bruno A, Piantanida E, Bartalena L, Tanda ML, Mortara L, Acquati F. | 01/14/2023 |
| Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion. | Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion.
Biener-Ramanujan E, Rosier F, Coetzee SG, McGovern DDP, Hazelett D, Targan SR, Gonsky R., Free PMC Article | 12/10/2022 |
| Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms. | Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms.
Shu Y, Ma X, Chen C, Wang Y, Sun X, Zhang L, Lu Z, Petersen F, Qiu W, Yu X. | 10/22/2022 |
| Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis. | Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis.
Bruno A, Noonan DM, Valli R, Porta G, Taramelli R, Mortara L, Acquati F., Free PMC Article | 09/3/2022 |
| FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer. | FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Ji M, Zhao Z, Li Y, Xu P, Shi J, Li Z, Wang K, Huang X, Liu B., Free PMC Article | 10/16/2021 |
| Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia. | Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia.
Weber T, Schlotawa L, Dosch R, Hamilton N, Kaiser J, Schiller S, Wenske B, Gärtner J, Henneke M., Free PMC Article | 08/28/2021 |
| Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway. | Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway.
Monaci S, Coppola F, Giuntini G, Roncoroni R, Acquati F, Sozzani S, Carraro F, Naldini A., Free PMC Article | 08/21/2021 |
| Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2. | Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.
Ostendorf T, Zillinger T, Andryka K, Schlee-Guimaraes TM, Schmitz S, Marx S, Bayrak K, Linke R, Salgert S, Wegner J, Grasser T, Bauersachs S, Soltesz L, Hübner MP, Nastaly M, Coch C, Kettwig M, Roehl I, Henneke M, Hoerauf A, Barchet W, Gärtner J, Schlee M, Hartmann G, Bartok E. | 11/21/2020 |
| the lysosomal endoribonuclease RNase T2 is a non-redundant upstream component of TLR8-dependent RNA recognition. | TLR8 Is a Sensor of RNase T2 Degradation Products.
Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T, Hornung V., Free PMC Article | 05/30/2020 |
| The human RNASET2 protein affects the polarization pattern of human macrophages in vitro. | The human RNASET2 protein affects the polarization pattern of human macrophages in vitro.
Scaldaferri D, Bosi A, Fabbri M, Pedrini E, Inforzato A, Valli R, Frattini A, De Vito A, Noonan DM, Taramelli R, Mortara L, Acquati F. | 08/10/2019 |
| In poorly differentiated lung neuroendocrine carcinomas, RNASET2 expression may be upregulated as a consequence of the activation of the hypoxia-induced HIF-1alpha pathway, thus behaving as an alarmin-like molecule. | New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1α.
Uccella S, La Rosa S, Scaldaferri D, Monti L, Maragliano R, Sorrenti E, Gariboldi M, Taramelli R, Sessa F, Acquati F. | 05/11/2019 |
| Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 | Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2).
Huang J, Liu P, Wang G., Free PMC Article | 04/20/2019 |
| High RNASET2 expression is associated with reduced sperm motility. | RNASET2 impairs the sperm motility via PKA/PI3K/calcium signal pathways.
Xu Y, Fan Y, Fan W, Jing J, Xue K, Zhang X, Ye B, Ji Y, Liu Y, Ding Z. | 11/3/2018 |
| Studied association of and RNASET2, GPR174, and PTPN22 gene polymorphisms and liver damage(LD) due to Graves' disease (GD) hyperthyroidism. Found GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 rs9355610 were significantly associated with altered GD-derived LD risk. | RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
Zhang Q, Liu S, Guan Y, Chen Q, Zhang Q, Min X., Free PMC Article | 06/2/2018 |
| RNASET2 is the enzyme that degrades the RNAs | Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2.
Liu P, Huang J, Zheng Q, Xie L, Lu X, Jin J, Wang G., Free PMC Article | 12/2/2017 |
| RNASET2, an IBD susceptibility gene, is a component of TL1A-mediated pathways regulating cytokine production. | Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease.
Gonsky R, Fleshner P, Deem RL, Biener-Ramanujan E, Li D, Potdar AA, Bilsborough J, Yang S, McGovern DPB, Targan SR., Free PMC Article | 09/9/2017 |
| inhibits melanocyte outgrowth through interacting with shootin1; this effect may be associated with vitiligo pathogenesis | Rnaset2 inhibits melanocyte outgrowth possibly through interacting with shootin1.
Wang Q, Wang X, Le Y, Jiang M, Wu J, Tao L, Kang Y, Xiang L. | 10/1/2016 |
| Biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limiting the damages and tissue remodeling events occurring during the earlier step of cell transformation. | Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase.
Lualdi M, Pedrini E, Rea K, Monti L, Scaldaferri D, Gariboldi M, Camporeale A, Ghia P, Monti E, Tomassetti A, Acquati F, Taramelli R., Free PMC Article | 05/28/2016 |
| RNASET2 may contribute to the development of vitiligo by inhibiting TNF Receptor-Associated Factor 2 expression and lead directly to apoptosis of melanocytes | Role and Mechanism of RNASET2 in the Pathogenesis of Vitiligo.
Wang Q, Wang X, Xiang L. | 03/19/2016 |
| describe a multi-step strategy that allows production of highly pure, catalytically competent recombinant RNASET2 in both wild-type and mutant forms | New Strategies for Expression and Purification of Recombinant Human RNASET2 Protein in Pichia pastoris.
Lualdi M, Pedrini E, Petroni F, Näsman J, Lindqvist C, Scaldaferri D, Taramelli R, Inforzato A, Acquati F. | 02/20/2016 |
| RNASET2 has antitumorigenic and antiangiogenic activities; a truncated version of human RNASET2, starting at E50 (trT2-50) and devoid of ribonuclease activity, has actin binding and anticancer-related biological activities | Human recombinant truncated RNASET2, devoid of RNase activity; A potential cancer therapeutic agent.
Nesiel-Nuttman L, Schwartz B, Shoseyov O., Free PMC Article | 09/26/2015 |
| RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population | RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population.
Chen XJ, Gong XH, Yan N, Meng S, Qin Q, Jiang YF, Zheng HY, Zhang JA., Free PMC Article | 07/4/2015 |