| USO1 isoforms differentially promote liver cancer progression by dysregulating the ER-Golgi network. | USO1 isoforms differentially promote liver cancer progression by dysregulating the ER-Golgi network.
Yoon S, Choi JH, Shah M, Kwon SM, Yang J, Park YN, Wang HJ, Woo HG. | 01/1/2022 |
| Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia. | Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.
Jaiswal AK, Truong H, Tran TM, Lin TL, Casero D, Alberti MO, Rao DS., Free PMC Article | 11/6/2021 |
| USO1 gene may be a promising target for the therapy of human multiple myeloma and its diagnosis marker. | USO1 promotes tumor progression via activating Erk pathway in multiple myeloma cells.
Jin Y, Dai Z. | 12/17/2016 |
| USO1 gene has a critical role in human colon cancer: USO1 is involved in cell proliferation and cell migration of colon cancer cells. | Lentivirus-mediated silencing of USO1 inhibits cell proliferation and migration of human colon cancer cells.
Sui J, Li X, Xing J, Cao F, Wang H, Gong H, Zhang W. | 04/30/2016 |
| P115 promotes proliferation of gastric cancer cells through an interaction with MIF. | P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor.
Li XJ, Luo Y, Yi YF., Free PMC Article | 06/28/2014 |
| Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology. | Scyl1 regulates Golgi morphology.
Burman JL, Hamlin JN, McPherson PS., Free PMC Article | 02/3/2012 |
| p115 plays a critical role in mitosis progression, implicating it as the only known golgin to regulate both mitosis and apoptosis | The Golgi protein p115 associates with gamma-tubulin and plays a role in Golgi structure and mitosis progression.
Radulescu AE, Mukherjee S, Shields D., Free PMC Article | 09/3/2011 |
| a conserved tethering function of the Golgi protein p115 CTF which promotes p53-ERK interaction for the amplification of the apoptotic signal. | Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway.
How PC, Shields D., Free PMC Article | 05/14/2011 |
| Data show that the number of tandem ARM repeats in an ARM fold ranges from 6 to 12. | Armadillo motifs involved in vesicular transport.
Striegl H, Andrade-Navarro MA, Heinemann U., Free PMC Article | 10/4/2010 |
| p115 is a critical intermediary component in the regulated secretion of MIF from monocytes/macrophages | The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.
Merk M, Baugh J, Zierow S, Leng L, Pal U, Lee SJ, Ebert AD, Mizue Y, Trent JO, Mitchell R, Nickel W, Kavathas PB, Bernhagen J, Bucala R., Free PMC Article | 01/21/2010 |
| terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering | Unusual armadillo fold in the human general vesicular transport factor p115.
Striegl H, Roske Y, Kümmel D, Heinemann U., Free PMC Article | 01/21/2010 |
| nuclear import of the p115 CTF is required for it to stimulate the apoptotic response and suggest that its mode of action is confined to the nucleus. | Nuclear import is required for the pro-apoptotic function of the Golgi protein p115.
Mukherjee S, Shields D., Free PMC Article | 01/21/2010 |
| Golgi organization depends on mutually interacting domains in betaCOP and p115, suggesting that vesicle tethering at the Golgi involves p115 binding to the COPI coat | Coat-tether interaction in Golgi organization.
Guo Y, Punj V, Sengupta D, Linstedt AD., Free PMC Article | 01/21/2010 |
| The interaction between p115 and Cog2 was found to be essential for Golgi ribbon reformation after the disruption of the ribbon by p115 KD or brefeldin A treatment and recovery by re-expression of p115 or drug wash out, respectively. | The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.
Sohda M, Misumi Y, Yoshimura S, Nakamura N, Fusano T, Ogata S, Sakisaka S, Ikehara Y. | 01/21/2010 |
| p115 acts directly, rather than via a tether, to catalyze trans-SNARE complex formation preceding membrane fusion. | Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis.
Puthenveedu MA, Linstedt AD., Free PMC Article | 01/21/2010 |
| Data show that p115 degradation plays a key role in amplifying the apoptotic response independently of Golgi fragmentation. | A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis.
Chiu R, Novikov L, Mukherjee S, Shields D., Free PMC Article | 01/21/2010 |
| The results suggest that p115 is involved in vesicular transport between endoplasmic reticulum and the Golgi, along with microtubule networks. | Depletion of vesicle-tethering factor p115 causes mini-stacked Golgi fragments with delayed protein transport.
Sohda M, Misumi Y, Yoshimura S, Nakamura N, Fusano T, Sakisaka S, Ogata S, Fujimoto J, Kiyokawa N, Ikehara Y. | 01/21/2010 |