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    TNFSF11 TNF superfamily member 11 [ Homo sapiens (human) ]

    Gene ID: 8600, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Elevated tissue expression of RANKL and RANK is associated with poorer survival rates in pancreatic cancer patients.

    Elevated tissue expression of RANKL and RANK is associated with poorer survival rates in pancreatic cancer patients.
    Ortega MA, Jiménez-Álvarez L, Fraile-Martinez O, Garcia-Montero C, De León-Oliva D, Toledo-Lobo MDV, Palacios E, Granado P, Esteban A, Guijarro LG, Pekarek L, Asúnsolo Á, López-González L, Bujan J, García-Honduvilla N, Álvarez-Mon M, Saez MA, Díaz-Pedrero R.

    09/11/2024
    Genetic Variants of the Receptor Activator Nuclear of kappaB Ligand Gene Increase the Risk of Rheumatoid Arthritis in a Mexican Mestizo Population: A Case-Control Study.

    Genetic Variants of the Receptor Activator Nuclear of κB Ligand Gene Increase the Risk of Rheumatoid Arthritis in a Mexican Mestizo Population: A Case-Control Study.
    Arturo NC, Ivan GJ, Betsabe CH, Emilio PE, Yussef EG, Alejandra RN, Tonatiuh GH, Alejandra VV, Ismael NA, Elena TS, Manuel PJ, Heriberto JC, Gerardo AE, Laura GL, Miriam SA., Free PMC Article

    08/14/2024
    Accumulation of gammadeltaT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-kappaB.

    Accumulation of γδT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-κB.
    Chang RQ, Dai JC, Qiu YH, Liang Y, Hu XY, Li MQ, He F.

    05/22/2024
    Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma.

    Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma.
    Li Z, Lu W, Yin F, Zeng P, Li H, Huang A., Free PMC Article

    04/24/2024
    Osteoprotegerin and receptor activator of the nuclear factor kappa B ligand (RANKL) in healthy pubertal girls - relationships with physical growth and classical bone turnover markers.

    Osteoprotegerin and receptor activator of the nuclear factor kappa B ligand (RANKL) in healthy pubertal girls - relationships with physical growth and classical bone turnover markers.
    Kulik-Rechberger B, Kozłowska M.

    04/12/2024
    RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-kappaB pathway.

    RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway.
    Takeda T, Tsubaki M, Genno S, Tomita K, Nishida S.

    03/25/2024
    The Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis.

    The Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis.
    Padovano C, Bianco SD, Sansico F, De Santis E, Tamiro F, Colucci M, Totti B, Di Iasio S, Bruno G, Panelli P, Miscio G, Mazza T, Giambra V., Free PMC Article

    12/6/2023
    RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes.

    RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes.
    Kondegowda NG, Filipowska J, Do JS, Leon-Rivera N, Li R, Hampton R, Ogyaadu S, Levister C, Penninger JM, Reijonen H, Levy CJ, Vasavada RC., Free PMC Article

    11/3/2023
    Pulling rank with RNA: RANKL promotes the association of PGC-1beta/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts.

    Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts.
    Torres HM, Yeo D, Westendorf JJ., Free PMC Article

    11/1/2023
    [RANKL and periodontitis].

    [RANKL and periodontitis].
    Ando Y, Tsukasaki M.

    10/28/2023
    Effect of Aerobic/Strength Training on RANKL Gene DNA Methylation Levels.

    Effect of Aerobic/Strength Training on RANKL Gene DNA Methylation Levels.
    Chelly A, Bouzid A, Neifar F, Kammoun I, Tekari A, Masmoudi S, Chtourou H, Rebai A.

    09/23/2023
    NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.

    NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.
    Li T, Qiu D, Chen Q, Yang A, Chen J, Zeng Z., Free PMC Article

    08/30/2023
    RANKL Promotes Chemotherapy Resistance in Breast Cancer Cells Through STAT3 Mediated Autophagy Induction.

    RANKL Promotes Chemotherapy Resistance in Breast Cancer Cells Through STAT3 Mediated Autophagy Induction.
    Tang ZN, Bi XF, Chen WL, Zhang CL.

    06/1/2023
    miR-4732-3p prevents lung cancer progression via inhibition of the TBX15/TNFSF11 axis.

    miR-4732-3p prevents lung cancer progression via inhibition of the TBX15/TNFSF11 axis.
    Li P, Li Y, Bai S, Zhang Y, Zhao L.

    05/17/2023
    MiR-217 regulates autophagy through OPG/RANKL/RANK in giant cell tumors.

    MiR-217 regulates autophagy through OPG/RANKL/RANK in giant cell tumors.
    Meng C, Jiang B, Liu W, Wang L, Zhao Z, Bai R, Zhao Y., Free PMC Article

    05/17/2023
    RANKL and RANK in Cancer Therapy.

    RANKL and RANK in Cancer Therapy.
    Onji M, Penninger JM.

    03/7/2023
    Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF-beta/PTHrP/RANKL pathway.

    Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF-β/PTHrP/RANKL pathway.
    Zhang C, Yang J, Zhu Z, Qin J, Yang L, Zhao X, Su W, Cai Y, Yang J, Wang F, Chen W, Gu H, Deng H, Wang Z.

    03/2/2023
    Expression of RANKL in breast cancer tissue in patients with fibrous dysplasia/McCune-Albright syndrome.

    Expression of RANKL in breast cancer tissue in patients with fibrous dysplasia/McCune-Albright syndrome.
    Meier ME, Hagelstein-Rotman M, Majoor BCJ, Geels RES, Appelman-Dijkstra NM, Bravenboer N.

    02/28/2023
    RANKL interferes with osteoclastogenesis in PEG-fused U937 cells through LGR4.

    RANKL interferes with osteoclastogenesis in PEG-fused U937 cells through LGR4.
    Arteaga JA, Guerrero CA.

    01/28/2023
    Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial.

    Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial.
    Peters S, Letovanec I, Mauer M, Dafni U, Ejedepang D, Biernat W, Bubendorf L, Warth A, Pokharel S, Reinmuth N, Majem Tarruella M, Casas-Martin J, Tsourti Z, Marti N, Kammler R, Danson S, O'Brien M, Stahel RA.

    01/28/2023
    The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies.

    The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies.
    Zhang Y, Liang J, Liu P, Wang Q, Liu L, Zhao H., Free PMC Article

    01/14/2023
    RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts.

    RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts.
    Bae S, Kim K, Kang K, Kim H, Lee M, Oh B, Kaneko K, Ma S, Choi JH, Kwak H, Lee EY, Park SH, Park-Min KH., Free PMC Article

    12/31/2022
    Risk association of RANKL and OPG gene polymorphism with breast cancer to bone metastasis in Pashtun population of Khyber Pakhtunkhwa, Pakistan.

    Risk association of RANKL and OPG gene polymorphism with breast cancer to bone metastasis in Pashtun population of Khyber Pakhtunkhwa, Pakistan.
    Hayat F, Khan NU, Khan AU, Ahmad I, Alamri AM, Iftikhar B., Free PMC Article

    11/19/2022
    Human mast cells induce osteoclastogenesis through cell surface RANKL.

    Human mast cells induce osteoclastogenesis through cell surface RANKL.
    Ng CW, Chan BCL, Ko CH, Tam IYS, Sam SW, Lau CBS, Leung PC, Lau HYA.

    11/5/2022
    Association of TNFSF11 rs2200287 and TNFSF11 rs2148072 gene polymorphisms in preeclampsia.

    Association of TNFSF11 rs2200287 and TNFSF11 rs2148072 gene polymorphisms in preeclampsia.
    Sivaraj N, Kusuma BP, Kutikuppala LVS, Rachel KV, Balaga VS, Gundakaram S.

    10/8/2022
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