| Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque. | Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque.
Liao FJ, Shen SL, Bao HL, Li H, Zhao QW, Chen L, Gong CW, Xiong CZ, Liu WP, Li W, Liu DN., Free PMC Article | 08/8/2024 |
| Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson's Disease Patients. | Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson's Disease Patients.
Babu HWS, Elangovan A, Iyer M, Kirola L, Muthusamy S, Jeeth P, Muthukumar S, Vanlalpeka H, Gopalakrishnan AV, Kadhirvel S, Kumar NS, Vellingiri B. | 08/6/2024 |
| Kynurenine 3-monooxygenase limits de novo NAD[+] synthesis through dietary tryptophan in renal proximal tubule epithelial cell models. | Kynurenine 3-monooxygenase limits de novo NAD(+) synthesis through dietary tryptophan in renal proximal tubule epithelial cell models.
Zhai Y, Chavez JA, D'Aquino KE, Meng R, Nawrocki AR, Pocai A, Wang L, Ma LJ. | 05/8/2024 |
| The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors. | The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors.
Hughes TD, Güner OF, Iradukunda EC, Phillips RS, Bowen JP., Free PMC Article | 02/12/2022 |
| Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas. | Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas.
Vázquez Cervantes GI, Pineda B, Ramírez Ortega D, Salazar A, González Esquivel DF, Rembao D, Zavala Vega S, Gómez-Manzo S, Pérez de la Cruz G, Pérez de la Cruz V., Free PMC Article | 11/22/2021 |
| Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion. | Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion.
Hornigold N, Dunn KR, Craven RA, Zougman A, Trainor S, Shreeve R, Brown J, Sewell H, Shires M, Knowles M, Fukuwatari T, Maher ER, Burns J, Bhattarai S, Menon M, Brazma A, Scelo G, Feulner L, Riazalhosseini Y, Lathrop M, Harris A, Selby PJ, Banks RE, Vasudev NS., Free PMC Article | 02/20/2021 |
| Kynurenine 3-monooxygenase upregulates pluripotent genes through beta-catenin and promotes triple-negative breast cancer progression. | Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression.
Huang TT, Tseng LM, Chen JL, Chu PY, Lee CH, Huang CT, Wang WL, Lau KY, Tseng MF, Chang YY, Chiang TY, Ueng YF, Lee HC, Dai MS, Liu CY., Free PMC Article | 02/2/2021 |
| A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics. | A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.
Maddison DC, Alfonso-Núñez M, Swaih AM, Breda C, Campesan S, Allcock N, Straatman-Iwanowska A, Kyriacou CP, Giorgini F., Free PMC Article | 01/9/2021 |
| There is the association between the rs1053230 polymorphism and depression. | [A study of the association between the kynurenine-3-monooxygenase gene and depression].
Lezheiko TV, Golimbet VE, Andryushchenko AV, Melik-Pashayan AE, Mironova EV. | 05/19/2018 |
| results show the incidence of Postpartum Depression in the Chinese population to be 7.3%, with PDS characterized by increased serum 3-HydroxyKinurenine concentration and 3-HK/Kynurenine ratio, versus matched postpartum women without PDS. Furthermore, polymorphisms of Kynurenine Monooxygenase rs1053230 are significantly associated with the incidence of PDS. | Genetic variants of the kynurenine-3-monooxygenase and postpartum depressive symptoms after cesarean section in Chinese women.
Wang SY, Duan KM, Tan XF, Yin JY, Mao XY, Zheng W, Wang CY, Yang M, Peng C, Zhou HH, Liu ZQ. | 07/8/2017 |
| Our data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes | Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.
Korstanje R, Deutsch K, Bolanos-Palmieri P, Hanke N, Schroder P, Staggs L, Bräsen JH, Roberts IS, Sheehan S, Savage H, Haller H, Schiffer M., Free PMC Article | 06/3/2017 |
| A comprehensive review of the molecular properties of KMO, including its kinetics, reaction mechanism, and inhibitor structure-activity relationship (SAR), is not currently available and, thus, is our focus here | Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors.
Smith JR, Jamie JF, Guillemin GJ. | 01/28/2017 |
| SiRNA knockdown of the pathway components Kynurenine 3-monooxygenase and quinolinate phosphoribosyl transferase caused cells to revert to a state of susceptibility to 3HK-mediated apoptosis. | Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback.
Wilson K, Auer M, Binnie M, Zheng X, Pham NT, Iredale JP, Webster SP, Mole DJ., Free PMC Article | 12/17/2016 |
| These results suggest that KMO exhibits tumor-promoting effects towards hepatocellular carcinoma (HCC) and it may serve as a novel prognostic marker in HCC. | Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma.
Jin H, Zhang Y, You H, Tao X, Wang C, Jin G, Wang N, Ruan H, Gu D, Huo X, Cong W, Qin W., Free PMC Article | 05/21/2016 |
| Results suggest that KMO variation influences a range of cognitive domains known to predict functional outcome in schizophrenia | Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia.
Wonodi I, McMahon RP, Krishna N, Mitchell BD, Liu J, Glassman M, Hong LE, Gold JM., Free PMC Article | 08/15/2015 |
| Two KMO SNPs were observed more often in schizophrenia patient group compared with healthy controls. | [Association of kynurenine-3-monooxygenase gene with schizophrenia].
Golimbet VE, Lezheiko TV, Alfimova MV, Abramova LI, Kondrat'ev NV. | 08/8/2015 |
| findings from five independent cohorts suggest that genetic variation in KMO influences the risk for psychotic features in mania of bipolar disorder patients. | The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.
Lavebratt C, Olsson S, Backlund L, Frisén L, Sellgren C, Priebe L, Nikamo P, Träskman-Bendz L, Cichon S, Vawter MP, Osby U, Engberg G, Landén M, Erhardt S, Schalling M., Free PMC Article | 11/8/2014 |
| Study reporting on the first successful bacterial (Escherichia coli) expression of active FLAGtrade mark-tagged human KMO enzyme expressed in the soluble fraction and progress towards its purification. | Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification.
Wilson K, Mole DJ, Binnie M, Homer NZ, Zheng X, Yard BA, Iredale JP, Auer M, Webster SP., Free PMC Article | 10/11/2014 |
| analyzed association between KMO gene polymorphisms and CSF concentrations of kynurenic acid in patients with schizophrenia and controls. results suggest that the nonsynonymous KMO SNP rs1053230 influences CSF concentrations of KYNA. | Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.
Holtze M, Saetre P, Engberg G, Schwieler L, Werge T, Andreassen OA, Hall H, Terenius L, Agartz I, Jönsson EG, Schalling M, Erhardt S., Free PMC Article | 05/5/2012 |
| significant and correlated reduction in gene expression and enzyme activity in the frontal eye field in schizophrenia patients; rs2275163 has modest effects on predictive pursuit and visuospatial working memory endophenotypes | Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes.
Wonodi I, Stine OC, Sathyasaikumar KV, Roberts RC, Mitchell BD, Hong LE, Kajii Y, Thaker GK, Schwarcz R., Free PMC Article | 09/17/2011 |
| The present analysis of the combined Scandinavian sample did not reveal any allele frequency difference between patients and healthy controls | Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: an association study.
Holtze M, Saetre P, Erhardt S, Schwieler L, Werge T, Hansen T, Nielsen J, Djurovic S, Melle I, Andreassen OA, Hall H, Terenius L, Agartz I, Engberg G, Jönsson EG, Schalling M, Holtze M, Saetre P, Erhardt S, Schwieler L, Werge T, Hansen T, Nielsen J, Djurovic S, Melle I, Andreassen OA, Hall H, Terenius L, Agartz I, Engberg G, Jönsson EG, Schalling M. | 07/2/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesKynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: an association study.
Holtze M, Saetre P, Erhardt S, Schwieler L, Werge T, Hansen T, Nielsen J, Djurovic S, Melle I, Andreassen OA, Hall H, Terenius L, Agartz I, Engberg G, Jönsson EG, Schalling M, Holtze M, Saetre P, Erhardt S, Schwieler L, Werge T, Hansen T, Nielsen J, Djurovic S, Melle I, Andreassen OA, Hall H, Terenius L, Agartz I, Engberg G, Jönsson EG, Schalling M. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
McCauley JL, Zuvich RL, Bradford Y, Kenealy SJ, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Mortlock DP, Pericak-Vance MA, Haines JL. Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population.
Aoyama N, Takahashi N, Saito S, Maeno N, Ishihara R, Ji X, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N, Aoyama N, Takahashi N, Saito S, Maeno N, Ishihara R, Ji X, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N. | 03/13/2008 |
| the function KMO AND indoleamine 2,3-dioxygenase may change from a role in immunosuppression at the maternal-fetal interface in early pregnancy, to one associated with regulation of fetoplacental blood flow or placental metabolism in late gestation | Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy.
Ligam P, Manuelpillai U, Wallace EM, Walker D. | 01/21/2010 |
| Results suggest that kynurenine 3-monooxygenase is unlikely to be related to the development of schizophrenia in Japanese. | Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population.
Aoyama N, Takahashi N, Saito S, Maeno N, Ishihara R, Ji X, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N, Aoyama N, Takahashi N, Saito S, Maeno N, Ishihara R, Ji X, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Yoshida K, Iwata N, Inada T, Ozaki N. | 01/21/2010 |