| RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma. | RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma.
Zhu J, Guo L, Dai H, Zheng Z, Yan J, Liu J, Zhang S, Li X, Sun X, Zhao Q, Xu C., Free PMC Article | 02/21/2024 |
| CDK10 suppresses metastasis of lung adenocarcinoma through inhibition of the ETS2/c-Raf/p-MEK/p-ERK signaling loop. | CDK10 suppresses metastasis of lung adenocarcinoma through inhibition of the ETS2/c-Raf/p-MEK/p-ERK signaling loop.
Zhang X, Zhao Y, Yiminniyaze R, Zhu N, Zhang Y, Wumaier G, Xia J, Dong L, Zhou D, Wang J, Li C, Zhang Y, Li S. | 12/15/2023 |
| CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples. | CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples.
Fredi BM, De Labio RW, Rasmussen LT, Chagas EFB, Chen ES, Turecki G, Smith MAC, Payão SLM. | 07/13/2023 |
| A sib-pair with Al Kaissi syndrome caused by homozygosity for a novel CDK10 splice variant. | A sib-pair with Al Kaissi syndrome caused by homozygosity for a novel CDK10 splice variant.
Beriwal A, Chauhan L, Kumar A, Dwivedi A. | 03/3/2023 |
| Functional characterization of the human Cdk10/Cyclin Q complex. | Functional characterization of the human Cdk10/Cyclin Q complex.
Düster R, Ji Y, Pan KT, Urlaub H, Geyer M., Free PMC Article | 05/7/2022 |
| Functional characterization of CDK10 and cyclin M truncated variants causing severe developmental disorders. | Functional characterization of CDK10 and cyclin M truncated variants causing severe developmental disorders.
Robert T, Dock-Bregeon AC, Colas P., Free PMC Article | 03/26/2022 |
| A large Canadian cohort provides insights into the genetic architecture of human hair colour. | A large Canadian cohort provides insights into the genetic architecture of human hair colour.
Lona-Durazo F, Mendes M, Thakur R, Funderburk K, Zhang T, Kovacs MA, Choi J, Brown KM, Parra EJ., Free PMC Article | 12/25/2021 |
| Gene expression network analysis of lymph node involvement in colon cancer identifies AHSA2, CDK10, and CWC22 as possible prognostic markers. | Gene expression network analysis of lymph node involvement in colon cancer identifies AHSA2, CDK10, and CWC22 as possible prognostic markers.
Han SW, Ahn JY, Lee S, Noh YS, Jung HC, Lee MH, Park HJ, Chun HJ, Choi SJ, Kim ES, Lee JY., Free PMC Article | 11/28/2020 |
| Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model. | Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model.
Zehra M, Mushtaq S, Ghulam Musharraf S, Ghani R, Ahmed N., Free PMC Article | 11/21/2020 |
| The present study illustrated that downregulation of CDK10 expression activated Snaildriven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy. | Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression.
Li H, You Y, Liu J. | 10/20/2018 |
| the results of the present study indicated that CDK10 expression may serve as a novel prognostic biomarker that holds therapeutic promise for gastric cancer. | Downregulated CDK10 expression in gastric cancer: Association with tumor progression and poor prognosis.
You Y, Bai F, Ye Z, Zhang N, Yao L, Tang Y, Li X. | 09/15/2018 |
| The findings of this study indicate that CDK10 plays a role in the pathogenesis in colorectal cancer and may be a potential therapeutic target for treatment. | Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2.
Weiswald LB, Hasan MR, Wong JCT, Pasiliao CC, Rahman M, Ren J, Yin Y, Gusscott S, Vacher S, Weng AP, Kennecke HF, Bièche I, Schaeffer DF, Yapp DT, Tai IT. | 07/21/2018 |
| These findings underscore the importance of CDK10 for the regulation of ciliogenesis. CDK10 defect is likely associated with a new form of ciliopathy phenotype; additional patients may further validate this association | A homozygous deleterious CDK10 mutation in a patient with agenesis of corpus callosum, retinopathy, and deafness.
Guen VJ, Edvardson S, Fraenkel ND, Fattal-Valevski A, Jalas C, Anteby I, Shaag A, Dor T, Gillis D, Kerem E, Lees JA, Colas P, Elpeleg O., Free PMC Article | 06/23/2018 |
| CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays. | CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.
Windpassinger C, Piard J, Bonnard C, Alfadhel M, Lim S, Bisteau X, Blouin S, Ali NB, Ng AYJ, Lu H, Tohari S, Talib SZA, van Hul N, Caldez MJ, Van Maldergem L, Yigit G, Kayserili H, Youssef SA, Coppola V, de Bruin A, Tessarollo L, Choi H, Rupp V, Roetzer K, Roschger P, Klaushofer K, Altmüller J, Roy S, Venkatesh B, Ganger R, Grill F, Ben Chehida F, Wollnik B, Altunoglu U, Al Kaissi A, Reversade B, Kaldis P., Free PMC Article | 10/28/2017 |
| CDK10/CycM is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. | STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.
Guen VJ, Gamble C, Perez DE, Bourassa S, Zappel H, Gärtner J, Lees JA, Colas P., Free PMC Article | 12/17/2016 |
| Down-regulated CDK10 expression frequently occurs in breast cancers and correlates with disease progression and poor survival | Decreased CDK10 expression correlates with lymph node metastasis and predicts poor outcome in breast cancer patients - a short report.
You Y, Li H, Qin X, Zhang Y, Song W, Ran Y, Gao F. | 09/17/2016 |
| Results found that CDK10 mRNA expression was up-regulated in advanced breast neoplasm and positively correlated with C1orf63, which was consistent with the relationship of protein expression between C1orf63 and CDK10. | Elevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study.
Hong CQ, Zhang F, You YJ, Qiu WL, Giuliano AE, Cui XJ, Zhang GJ, Cui YK., Free PMC Article | 05/14/2016 |
| Data suggest that reactivation of CDK10 might be utilized as a novel epigenetic strategy for the treatment of nasopharyngeal carcinomas (NPC) patients. | Promoter hypermethylation contributes to the frequent suppression of the CDK10 gene in human nasopharyngeal carcinomas.
You Y, Yang W, Wang Z, Zhu H, Li H, Lin C, Ran Y. | 03/8/2014 |
| CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. | CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.
Guen VJ, Gamble C, Flajolet M, Unger S, Thollet A, Ferandin Y, Superti-Furga A, Cohen PA, Meijer L, Colas P., Free PMC Article | 02/1/2014 |
| Data show that peptidyl-prolyl isomerase Pin1 silencing in SKBR-3 and MCF7 cells increased the cyclin-dependent kinase 10 (CDK10) expression. | Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells.
Khanal P, Yun HJ, Lim SC, Ahn SG, Yoon HE, Kang KW, Hong R, Choi HS. | 11/3/2012 |
| CDK10 plays a crucial role in the growth and survivability of biliary tract cancer. | CDK10 functions as a tumor suppressor gene and regulates survivability of biliary tract cancer cells.
Yu JH, Zhong XY, Zhang WG, Wang ZD, Dong Q, Tai S, Li H, Cui YF., Free PMC Article | 06/2/2012 |
| reduced Cdk10 expression is closely linked to hepatocellular carcinoma development and progression | Clinical and biological significance of Cdk10 in hepatocellular carcinoma.
Zhong XY, Xu XX, Yu JH, Jiang GX, Yu Y, Tai S, Wang ZD, Cui YF. | 05/12/2012 |
| CDK10 is not a target for aberrant DNA methylation in breast cancer. | CDK10 is not a target for aberrant DNA methylation in breast cancer.
Heller G, Ziegler B, Brandstetter A, Novak S, Rudas M, Hennig G, Gehrmann M, Acht T, Zöchbauer-Müller S, Filipits M. | 01/21/2010 |