| Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress. | Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress.
Westhorpe R, Keszthelyi A, Minchell NE, Jones D, Baxter J., Free PMC Article | 01/2/2021 |
| Results suggest that the Tof1 replicative function exerts its protective role when fork stalling is severe enough to require extra stabilization, such as at long expanded CAG repeats. | Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function.
Gellon L, Kaushal S, Cebrián J, Lahiri M, Mirkin SM, Freudenreich CH., Free PMC Article | 08/24/2019 |
| Phosphorylation regulates the recruitment and retention of Tof1-Csm3 by the replisome and that this complex antagonizes the Rrm3 helicase, thereby promoting replication fork arrest. | Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.
Bastia D, Srivastava P, Zaman S, Choudhury M, Mohanty BK, Bacal J, Langston LD, Pasero P, O'Donnell ME., Free PMC Article | 12/16/2017 |
| although fork rotation and precatenation facilitate unwinding in hard-to-replicate contexts, they intrinsically disrupt normal chromosome duplication and are therefore restricted by Timeless/Tipin | Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability.
Schalbetter SA, Mansoubi S, Chambers AL, Downs JA, Baxter J., Free PMC Article | 04/30/2016 |
| Tof1, Mrc1 and Csm3 complex, inhibits CAG.CTG repeat instability. | Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms.
Razidlo DF, Lahue RS., Free PMC Article | 01/17/2015 |
| Authors show that minisatellite length expansions are controlled by the products of the CSM3 and TOF1 genes, while contractions are controlled by MRC1. | The role of CSM3, MRC1, and TOF1 in minisatellite stability and large loop DNA repair during meiosis in yeast.
LeClere AR, Yang JK, Kirkpatrick DT., Free PMC Article | 06/1/2013 |
| Data show that that ISC1 controls cell morphology in combination with checkpoint regulators Swe1, Cdk1(CDC28), MRC1, TOF1, CSM3, RAD9 and Rad53. | Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae.
Tripathi K, Matmati N, Zheng WJ, Hannun YA, Mohanty BK., Free PMC Article | 02/18/2012 |
| Functional Tof1 protein, a replication fork-stabilizing protein, precludes expansions of various unstable repeats. | Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast.
Cherng N, Shishkin AA, Schlager LI, Tuck RH, Sloan L, Matera R, Sarkar PS, Ashizawa T, Freudenreich CH, Mirkin SM., Free PMC Article | 04/16/2011 |
| The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae. | The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae.
Bairwa NK, Mohanty BK, Stamenova R, Curcio MJ, Bastia D., Free PMC Article | 03/5/2011 |
| Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks | Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks.
Bando M, Katou Y, Komata M, Tanaka H, Itoh T, Sutani T, Shirahige K., Free PMC Article | 01/21/2010 |
| Mrc1 and Tof1 control the normal progression of DNA replication forks in distinct ways. | Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase.
Hodgson B, Calzada A, Labib K., Free PMC Article | 01/21/2010 |
| analyzed sister-chromatid cohesion in double mutants of mrc1Delta, tof1Delta, and csm3Delta and identified additive cohesion defects that indicated the existence of at least two pathways that contribute to sister-chromatid cohesion | Genetic dissection of parallel sister-chromatid cohesion pathways.
Xu H, Boone C, Brown GW., Free PMC Article | 01/21/2010 |
| Involement of TOF1 in the DNA damage response. | Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response.
O'Neill BM, Hanway D, Winzeler EA, Romesberg FE., Free PMC Article | 01/21/2010 |
| Data show that the Tof1/Csm3/Mrc1 checkpoint complex interacts directly with the MCM helicase during both replication fork progression and when the replication fork is stalled. | Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.
Nedelcheva MN, Roguev A, Dolapchiev LB, Shevchenko A, Taskov HB, Shevchenko A, Stewart AF, Stoynov SS. | 01/21/2010 |
| Tof1p-Csm3p function differently from MRC1 and their complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae | The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae.
Mohanty BK, Bairwa NK, Bastia D., Free PMC Article | 01/21/2010 |