| Contribution of the yeast bi-chaperone system in the restoration of the RNA helicase Ded1 and translational activity under severe ethanol stress. | Contribution of the yeast bi-chaperone system in the restoration of the RNA helicase Ded1 and translational activity under severe ethanol stress.
Ando R, Ishikawa Y, Kamada Y, Izawa S., Free PMC Article | 01/3/2024 |
| The DEAD-Box RNA Helicase Ded1 Is Associated with Translating Ribosomes. | The DEAD-Box RNA Helicase Ded1 Is Associated with Translating Ribosomes.
Yeter-Alat H, Belgareh-Touzé N, Huvelle E, Banroques J, Tanner NK., Free PMC Article | 08/30/2023 |
| A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast. | A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast.
Carey SB, List HM, Siby A, Guerra P, Bolger TA., Free PMC Article | 01/21/2023 |
| G-quadruplex DNA inhibits unwinding activity but promotes liquid-liquid phase separation by the DEAD-box helicase Ded1p. | G-quadruplex DNA inhibits unwinding activity but promotes liquid-liquid phase separation by the DEAD-box helicase Ded1p.
Gao J, Gao Z, Putnam AA, Byrd AK, Venus SL, Marecki JC, Edwards AD, Lowe HM, Jankowsky E, Raney KD., Free PMC Article | 09/18/2021 |
| Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation. | Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation.
Brown NP, Vergara AM, Whelan AB, Guerra P, Bolger TA., Free PMC Article | 09/4/2021 |
| The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast. | The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast.
Mokdadi M, Abdelkrim YZ, Banroques J, Huvelle E, Oualha R, Yeter-Alat H, Guizani I, Barhoumi M, Tanner NK., Free PMC Article | 07/31/2021 |
| Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo. | Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo.
Gulay S, Gupta N, Lorsch JR, Hinnebusch AG., Free PMC Article | 03/20/2021 |
| Results are consistent with a model wherein Ded1 stalls translation and specifically removes eIF4G1 from translation preinitiation complexes, thus removing eIF4G1 from the translating mRNA pool and leading to the codegradation of both proteins. | The DEAD-box RNA helicase Ded1 has a role in the translational response to TORC1 inhibition.
Aryanpur PP, Renner DM, Rodela E, Mittelmeier TM, Byrd A, Bolger TA., Free PMC Article | 06/13/2020 |
| Functional interplay between Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in Saccharomyces cerevisiae has been reported. | Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo.
Sen ND, Gupta N, K Archer S, Preiss T, Lorsch JR, Hinnebusch AG., Free PMC Article | 12/7/2019 |
| We propose a model where ATP-bound Ded1 stabilizes partially unwound duplexes and where multiple binding events may be needed to see displacement | Mechanistic characterization of the DEAD-box RNA helicase Ded1 from yeast as revealed by a novel technique using single-molecule magnetic tweezers.
Raj S, Bagchi D, Orero JV, Banroques J, Tanner NK, Croquette V., Free PMC Article | 10/12/2019 |
| Ded1p affects translation initiation by controlling the use of near-cognate initiation codons that are proximal to mRNA structure in 5' untranslated regions | The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs.
Guenther UP, Weinberg DE, Zubradt MM, Tedeschi FA, Stawicki BN, Zagore LL, Brar GA, Licatalosi DD, Bartel DP, Weissman JS, Jankowsky E., Free PMC Article | 12/22/2018 |
| These results reveal and characterize an unexpected interdependence between the two RNA helicases and eIF4G, and suggest that Ded1p is an integral part of eIF4F, the complex comprising eIF4G, eIF4A, and eIF4E. | Coupling between the DEAD-box RNA helicases Ded1p and eIF4A.
Gao Z, Putnam AA, Bowers HA, Guenther UP, Ye X, Kindsfather A, Hilliker AK, Jankowsky E., Free PMC Article | 11/4/2017 |
| Findings suggest that Ded1 is critically required to promote scanning through secondary structures within 5' UTRs, and while eIF4A cooperates with Ded1 in this function, it also promotes a step of initiation common to virtually all yeast mRNAs. | Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A.
Sen ND, Zhou F, Ingolia NT, Hinnebusch AG., Free PMC Article | 05/28/2016 |
| Oligomerization represents a previously unappreciated level of regulation for Ded1p DEAD-box helicase activities. | Division of Labor in an Oligomer of the DEAD-Box RNA Helicase Ded1p.
Putnam AA, Gao Z, Liu F, Jia H, Yang Q, Jankowsky E., Free PMC Article | 04/30/2016 |
| Individual members of the Ded1/DDX3 subfamily perform multiple functions in RNA metabolism in both nucleus and cytoplasm. [review] | The Ded1/DDX3 subfamily of DEAD-box RNA helicases.
Sharma D, Jankowsky E. | 02/28/2015 |
| The authors conclude that Ded1 is an mRNP cofactor of the cap complex that may function to remodel the different mRNPs and thereby regulate the expression of the mRNAs. | The DEAD-box helicase Ded1 from yeast is an mRNP cap-associated protein that shuttles between the cytoplasm and nucleus.
Senissar M, Le Saux A, Belgareh-Touzé N, Adam C, Banroques J, Tanner NK., Free PMC Article | 12/6/2014 |
| DEAD-box helicase Ded1p forms exceptionally long-lived complexes with RNA | DEAD-box helicases form nucleotide-dependent, long-lived complexes with RNA.
Liu F, Putnam AA, Jankowsky E. | 07/12/2014 |
| Ded1p and glyceraldehyde-3-phosphate dehydrogenase enhance tombusvirus (+)-strand synthesis | A Co-Opted DEAD-Box RNA helicase enhances tombusvirus plus-strand synthesis.
Kovalev N, Pogany J, Nagy PD., Free PMC Article | 06/16/2012 |
| Gle1 is a multifunctional DEAD-box protein regulator that modulates Ded1 in translation initiation. | Gle1 is a multifunctional DEAD-box protein regulator that modulates Ded1 in translation initiation.
Bolger TA, Wente SR., Free PMC Article | 01/7/2012 |
| Ded1 is a translation initiation factor that assembles and remodels an intermediate complex in translation initiation. | The DEAD-box protein Ded1 modulates translation by the formation and resolution of an eIF4F-mRNA complex.
Hilliker A, Gao Z, Jankowsky E, Parker R., Free PMC Article | 11/12/2011 |
| motif III and the binding energy of gamma-PO(4) of ATP are used to coordinate motifs I, II, and VI and the two RecA-like domains to create a high-affinity single-stranded RNA binding site | Motif III in superfamily 2 "helicases" helps convert the binding energy of ATP into a high-affinity RNA binding site in the yeast DEAD-box protein Ded1.
Banroques J, Doère M, Dreyfus M, Linder P, Tanner NK. | 04/12/2010 |
| the energy from ATP hydrolysis is dispensable for strand separation. ATP binding, however, appears necessary. ATP hydrolysis is found to be required for fast enzyme release from the RNA and multiple substrate turnovers and thus for enzyme recycling. | ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding.
Liu F, Putnam A, Jankowsky E., Free PMC Article | 01/21/2010 |
| DEAD-box proteins CYT-19, Mss116p, and Ded1p can achieve complete strand separation using a single ATP | DEAD-box proteins can completely separate an RNA duplex using a single ATP.
Chen Y, Potratz JP, Tijerina P, Del Campo M, Lambowitz AM, Russell R., Free PMC Article | 01/21/2010 |
| Ded1p is a bifunctional protein that can affect both translation initiation and P-body formation. | The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies.
Beckham C, Hilliker A, Cziko AM, Noueiry A, Ramaswami M, Parker R., Free PMC Article | 01/21/2010 |
| Intragenic suppressors of the F405L mutation in Ded1 mapped close to regions of the protein involved in ATP or RNA binding in DEAD-box crystal structures, which implicated a defect at this level. | A conserved phenylalanine of motif IV in superfamily 2 helicases is required for cooperative, ATP-dependent binding of RNA substrates in DEAD-box proteins.
Banroques J, Cordin O, Doère M, Linder P, Tanner NK., Free PMC Article | 01/21/2010 |