| Yca1 metacaspase: diverse functions determine how yeast live and let die. | Yca1 metacaspase: diverse functions determine how yeast live and let die.
Lam DK, Sherlock G., Free PMC Article | 04/14/2023 |
| The polyunsaturated fatty acid-producing strain also showed great increase in metacaspase Yca1p activity, suggesting cells could die by caspase-mediated cell death. | PUFA-induced cell death is mediated by Yca1p-dependent and -independent pathways, and is reduced by vitamin C in yeast.
Johansson M, Chen X, Milanova S, Santos C, Petranovic D. | 10/22/2016 |
| The yeast metacaspase regulates both proteolytic activities through the ubiquitin-proteasome system and ceramide metabolism as revealed by proteome and metabolome profiling of YCA1-knock-out cells during acetic-acid induced programmed cell death. | Proteome and metabolome profiling of wild-type and YCA1-knock-out yeast cells during acetic acid-induced programmed cell death.
Longo V, Ždralević M, Guaragnella N, Giannattasio S, Zolla L, Timperio AM. | 09/3/2016 |
| Using a combination of proteomics and , it was shown that YCA1 deletion down-regulated glycolysis, the TCA cycle and alcoholic fermentation compared with WT cells. | Differential proteome-metabolome profiling of YCA1-knock-out and wild type cells reveals novel metabolic pathways and cellular processes dependent on the yeast metacaspase.
Ždralević M, Longo V, Guaragnella N, Giannattasio S, Timperio AM, Zolla L. | 02/20/2016 |
| Life-span extension and aggregate management by Mca1 was only partly dependent on its conserved catalytic cysteine, which suggests that Mca1 harbors both caspase-dependent and independent functions related to life-span control. | Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae.
Hill SM, Hao X, Liu B, Nyström T. | 07/12/2014 |
| protein degradation factors such as Cdc48 co-localize with Yca1 to the insoluble fraction, supporting the hypothesis that Yca1 may act primarily to dissolve or reduce accumulated aggregates. | The role of Yca1 in proteostasis. Yca1 regulates the composition of the insoluble proteome.
Shrestha A, Puente LG, Brunette S, Megeney LA. | 09/14/2013 |
| structural and biochemical characterization identifies Yca1 as a Ca(2+)-activated cysteine protease that may cleave specific substrates during stress response in yeast. | Crystal structure of the yeast metacaspase Yca1.
Wong AH, Yan C, Shi Y., Free PMC Article | 11/24/2012 |
| Metacaspase is associated with mitochondrial respiration, intracellular redox control and genomic stability. | The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells.
Lefevre S, Sliwa D, Auchère F, Brossas C, Ruckenstuhl C, Boggetto N, Lesuisse E, Madeo F, Camadro JM, Santos R. | 03/10/2012 |
| the aggregation propensity of the potential yeast prion protein Mca1 in vivo is strongly accelerated by a short peptide segment preceding its Q/N-rich region | Extra N-terminal residues have a profound effect on the aggregation properties of the potential yeast prion protein Mca1.
Erhardt M, Wegrzyn RD, Deuerling E., Free PMC Article | 01/15/2011 |
| Data show that Yca1 protein complexes are enriched for aggregate-remodeling chaperones that colocalize with Yca1-GFP fusions. | Metacaspase Yca1 is required for clearance of insoluble protein aggregates.
Lee RE, Brunette S, Puente LG, Megeney LA., Free PMC Article | 10/4/2010 |
| alternative death pathways can be activated in yeast acetic acid-induced programmed cell death, one dependent on cyt c release, which requires YCA1, and the other(s) independent on it. | Yeast acetic acid-induced programmed cell death can occur without cytochrome c release which requires metacaspase YCA1.
Guaragnella N, Bobba A, Passarella S, Marra E, Giannattasio S. | 01/25/2010 |
| Yca1p participates in the G2/M mitotic checkpoint in the yeast cell cycle. | A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics.
Lee RE, Puente LG, Kaern M, Megeney LA., Free PMC Article | 01/21/2010 |
| Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae. | Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae.
Khan MA, Chock PB, Stadtman ER., Free PMC Article | 01/21/2010 |
| programmed cell death in wild-type cells occurs via a Yca1p caspase and a non-caspase route with similar characteristics | YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase-like activity.
Guaragnella N, Pereira C, Sousa MJ, Antonacci L, Passarella S, Côrte-Real M, Marra E, Giannattasio S. | 01/21/2010 |
| YCA1 overexpression, without any external stimulus, had a detrimental effect on growth and viability of ubp10 cells accompanied by an increase of apoptotic cells. | Involvement of the yeast metacaspase Yca1 in ubp10Delta-programmed cell death.
Bettiga M, Calzari L, Orlandi I, Alberghina L, Vai M. | 01/21/2010 |