| Structure of the PCNA unloader Elg1-RFC. | Structure of the PCNA unloader Elg1-RFC.
Zheng F, Yao NY, Georgescu RE, Li H, O'Donnell ME., Free PMC Article | 03/7/2024 |
| Timely removal of PCNA from DNA by the Elg1 complex is important to prevent mutations. The mutator phenotype of elg1Delta is attenuated by PCNA mutants that spontaneously fall off DNA. The elg1Delta mutator phenotype is exacerbated by PCNA mutants that accumulate on DNA due to enhanced electrostatic PCNA-DNA interactions. | Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.
Paul Solomon Devakumar LJ, Gaubitz C, Lundblad V, Kelch BA, Kubota T., Free PMC Article | 01/11/2020 |
| We find that the major cause of the chromatin organization defects of an ELG1 mutant is PCNA retention on DNA following replication, with Rtt106-Elg1 interaction potentially playing a contributory role. | Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation.
Gali VK, Dickerson D, Katou Y, Fujiki K, Shirahige K, Owen-Hughes T, Kubota T, Donaldson AD., Free PMC Article | 03/2/2019 |
| proliferating cell nuclear antigen (PCNA) unloading activity of Elg1 is important for coordinating DNA replication forks with the process of replication-coupled nucleosome assembly to maintain silencing of HML and HMR through S-phase | Pivotal roles of PCNA loading and unloading in heterochromatin function.
Janke R, King GA, Kupiec M, Rine J., Free PMC Article | 08/11/2018 |
| the various roles of Elg1 in genome stability maintenance involve the unloading of both modified and unmodified PCNA. | A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance.
Shemesh K, Sebesta M, Pacesa M, Sau S, Bronstein A, Parnas O, Liefshitz B, Venclovas C, Krejci L, Kupiec M., Free PMC Article | 08/26/2017 |
| results suggest that Elg1-RLC acts as a general PCNA unloader and is dependent upon DNA ligation during chromosome replication. | Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation.
Kubota T, Katou Y, Nakato R, Shirahige K, Donaldson AD., Free PMC Article | 05/14/2016 |
| ELG1 deletion from pds5-1 mutant cells results in a significant rescue of chromatid cohesion, but not condensation, defects | Pds5 regulators segregate cohesion and condensation pathways in Saccharomyces cerevisiae.
Tong K, Skibbens RV., Free PMC Article | 10/17/2015 |
| A high copy number suppressor screen was performed to search for genes that, when overexpressed, suppress the synthetic lethality between elg1Delta and srs2Delta mutants. | A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast.
Gazy I, Liefshitz B, Bronstein A, Parnas O, Atias N, Sharan R, Kupiec M., Free PMC Article | 02/22/2014 |
| Elg1 physically contacts the Mhf1/Mhf2 histone-like complex and genetically interacts with MPH1 (ortholog of the FANCM helicase) and CHL1 (ortholog of the FANCJ helicase) genes. | Genetic and physical interactions between the yeast ELG1 gene and orthologs of the Fanconi anemia pathway.
Singh S, Shemesh K, Liefshitz B, Kupiec M., Free PMC Article | 12/21/2013 |
| Elg1-replication factor C-like complex functions in unloading of both unmodified and SUMOylated PCNA during DNA replication. | The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication.
Kubota T, Nishimura K, Kanemaki MT, Donaldson AD. | 07/6/2013 |
| Elg1 binds proteins that interact with SUMO. | Elg1, the major subunit of an alternative RFC complex, interacts with SUMO-processing proteins.
Parnas O, Amishay R, Liefshitz B, Zipin-Roitman A, Kupiec M. | 03/24/2012 |
| show that yeast Elg1 interacts physically and genetically with PCNA, in a manner that depends on PCNA modification, and exhibits preferential affinity for SUMOylated PCNA. | Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA.
Parnas O, Zipin-Roitman A, Pfander B, Liefshitz B, Mazor Y, Ben-Aroya S, Jentsch S, Kupiec M., Free PMC Article | 08/30/2010 |
| Results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring. | The ELG1 clamp loader plays a role in sister chromatid cohesion.
Parnas O, Zipin-Roitman A, Mazor Y, Liefshitz B, Ben-Aroya S, Kupiec M., Free PMC Article | 01/21/2010 |
| demonstrated that the N-terminus of Elg1 contributes to the maintenance of genome stability, and that one function of this N-terminus is to promote the nuclear localization of Elg1 | The N- and C-termini of Elg1 contribute to the maintenance of genome stability.
Davidson MB, Brown GW. | 01/21/2010 |
| Results suggest that Elg1 is involved in double strand break repair repair by homologous recombination. | Role of Elg1 protein in double strand break repair.
Ogiwara H, Ui A, Enomoto T, Seki M., Free PMC Article | 01/21/2010 |
| elg1-deficient Saccharomyces cerevisiae mutants have increased genome instability and telomere length regulated by S-phase checkpoints | Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints.
Banerjee S, Myung K., Free PMC Article | 01/21/2010 |
| Elg1 function is required for maintaining genome stability during normal growth, and its absence has severe genetic consequences. | The Elg1 replication factor C-like complex: a novel guardian of genome stability.
Aroya SB, Kupiec M. | 01/21/2010 |