| The multifaceted role of GCM1 during trophoblast differentiation in the human placenta. | The multifaceted role of GCM1 during trophoblast differentiation in the human placenta.
Jeyarajah MJ, Jaju Bhattad G, Kelly RD, Baines KJ, Jaremek A, Yang FP, Okae H, Arima T, Dumeaux V, Renaud SJ., Free PMC Article | 12/10/2022 |
| Functional antagonism between DeltaNp63alpha and GCM1 regulates human trophoblast stemness and differentiation. | Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation.
Wang LJ, Chen CP, Lee YS, Ng PS, Chang GD, Pao YH, Lo HF, Peng CH, Cheong ML, Chen H., Free PMC Article | 04/23/2022 |
| Induction of the PPARgamma (Peroxisome Proliferator-Activated Receptor gamma)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta. | Induction of the PPARγ (Peroxisome Proliferator-Activated Receptor γ)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta.
Armistead B, Kadam L, Siegwald E, McCarthy FP, Kingdom JC, Kohan-Ghadr HR, Drewlo S., Free PMC Article | 10/30/2021 |
| Aberrant Gcm1 expression mediates Wnt/beta-catenin pathway activation in folate deficiency involved in neural tube defects. | Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects.
Li J, Xie Q, Gao J, Wang F, Bao Y, Wu L, Yang L, Liu Z, Guo R, Khan A, Dan Liu, Li C, Wu J, Xie J., Free PMC Article | 09/18/2021 |
| our studies demonstrate that DLX3 physically interacts with GCM1 and inhibits its transactivation activity, suggesting that DLX3 and GCM1 may form a complex to functionally regulate placental cell function through modulation of target gene expression. | DLX3 interacts with GCM1 and inhibits its transactivation-stimulating activity in a homeodomain-dependent manner in human trophoblast-derived cells.
Li S, Roberson MS., Free PMC Article | 12/22/2018 |
| results suggest that p45 NF-E2 negatively regulates differentiation and apoptosis activation of human syncytiotrophoblast by modulating GCM1 acetylation and sumoylation. | p45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction.
Kohli S, Hoffmann J, Lochmann F, Markmeyer P, Huebner H, Fahlbusch FB, Al-Dabet MM, Gadi I, Manoharan J, Löttge M, Zenclussen AC, Aharon A, Brenner B, Shahzad K, Ruebner M, Isermann B., Free PMC Article | 11/25/2017 |
| Identify a novel cis-acting sequence (-369 to -320) at the placental growth factor promoter, which was critical for mediating the basal and DLX3/GCM1-dependent PGF promoter activities. | Dlx3 and GCM-1 functionally coordinate the regulation of placental growth factor in human trophoblast-derived cells.
Li S, Roberson MS. | 09/23/2017 |
| Twist1 may promote trophoblast syncytialization by regulating the expression of GCM1. | Twist1 is involved in trophoblast syncytialization by regulating GCM1.
Lu X, He Y, Zhu C, Wang H, Chen S, Lin HY. | 01/14/2017 |
| GATA3 knockdown elevated HtrA4 expression in BeWo and JEG-3 trophoblast cell lines and enhanced the invasion activities of both lines. This study uncovered a new GATA3 function in placenta as a negative regulator of GCM1 activity and trophoblastic invasion. | GATA3 inhibits GCM1 activity and trophoblast cell invasion.
Chiu YH, Chen H., Free PMC Article | 12/31/2016 |
| GLI2 stabilized glial cell missing-a, a pivotal transcriptional factor for trophoblastic syncytialization. | Glioma-associated Oncogene 2 Is Essential for Trophoblastic Fusion by Forming a Transcriptional Complex with Glial Cell Missing-a.
Tang C, Tang L, Wu X, Xiong W, Ruan H, Hussain M, Wu J, Zou C, Wu X., Free PMC Article | 08/6/2016 |
| reveals a positive feedback loop between glial cells missing 1 and Human chorionic gonadotropin regulating placental hCGbeta expression and cell differentiation | A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCGβ Expression and Cell Differentiation.
Cheong ML, Wang LJ, Chuang PY, Chang CW, Lee YS, Lo HF, Tsai MS, Chen H., Free PMC Article | 04/30/2016 |
| Gcm1 and Fzd5 function in an evolutionary conserved positive feedback loop that regulates trophoblast differentiation and sites of chorionic branching morphogenesis. | A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.
Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang H, Wang Y, van Es JH, Clevers H, Leone G, Cross JC, Wang H., Free PMC Article | 10/19/2013 |
| Results suggest that caspase-14 may interact with GCM1 to participate in syncytiotrophoblast differentiation during placental development. | Caspase-14 suppresses GCM1 acetylation and inhibits placental cell differentiation.
Wu YH, Lo HF, Chen SH, Chen H. | 09/21/2013 |
| study reveals a novel function for RACK1 to regulate GCM1 activity and placental cell migration and invasion | RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion.
Wang CC, Lo HF, Lin SY, Chen H. | 09/21/2013 |
| GCM1-directed villous trophoblast differentiation is repressed by DREAM | DREAM mediated regulation of GCM1 in the human placental trophoblast.
Baczyk D, Kibschull M, Mellstrom B, Levytska K, Rivas M, Drewlo S, Lye SJ, Naranjo JR, Kingdom JC., Free PMC Article | 08/31/2013 |
| c-Myc-regulated members of the miR-17~92 and miR-106a~363 clusters inhibit trophoblast differentiation by repressing GCM1 and CYP19A1. | The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation.
Kumar P, Luo Y, Tudela C, Alexander JM, Mendelson CR., Free PMC Article | 06/1/2013 |
| Phorbol 12-myristate 13-acetate-induced protein kinase C and mitogen-activated protein kinase kinase/extracellular signal regulated kinase dependent pathway enhances the degradation as well as the transcriptional activity of GCMa. | PMA-induced GCMa phosphorylation stimulates its transcriptional activity and degradation.
Yasui Y, Miyazawa D, Ueda H, Sato K, Kitade Y, Yamada K. | 02/2/2013 |
| study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia | High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion.
Wang LJ, Cheong ML, Lee YS, Lee MT, Chen H., Free PMC Article | 11/24/2012 |
| Data show that beta-catenin/BCL9-Like (BCL9L)/T-cell factor 4 (TCF4) signalling directly targets the GCM1/syncytin pathway and thereby regulates the fusion of human choriocarcinoma cells. | Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T. | 05/19/2012 |
| results support a role for reduced placental Gcm1 expression as a causative factor in defective syncytiotrophoblast differentiation and maternal and placental phenotypes in preeclampsia in humans. | Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.
Bainbridge SA, Minhas A, Whiteley KJ, Qu D, Sled JG, Kingdom JC, Adamson SL. | 04/21/2012 |
| these data demonstrate for the first time that GCMa is phosphorylated by the PKC- and MEK/extracellular signal-regulated kinase (ERK)-dependent mechanism, and that this phosphorylation is involved in its degradation process. | PMA induces GCMa phosphorylation and alters its stability via the PKC- and ERK-dependent pathway.
Yasui Y, Yamada K, Takahashi S, Sugiura-Ogasawara M, Sato K, Miyazawa D, Sugiyama T, Kitade Y, Ueda H. | 04/7/2012 |
| CD9 increases GCM1 expression via the cAMP/PKA signaling pathway, resulting in the increase in ERVWE1 expression. | CD9 regulates transcription factor GCM1 and ERVWE1 expression through the cAMP/protein kinase A signaling pathway.
Muroi Y, Sakurai T, Hanashi A, Kubota K, Nagaoka K, Imakawa K. | 01/14/2012 |
| Our study has identi fi ed a novel cAMP/Epac1/CaMKI/GCM1 signaling cascade that stimulates trophoblast fusion through promoting GCM1 phosphorylation and desumoylation. | A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion.
Chang CW, Chang GD, Chen H., Free PMC Article | 10/29/2011 |
| TIMP4 is a downstream target of GCM1. | Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi.
Drewlo S, Czikk M, Baczyk D, Lye S, Kingdom J. | 08/13/2011 |
| Our results suggest that GCM1 is a critical factor in controlling placental cell fusion through transcriptional regulation of syncytin 2 and MFSD2A gene expression in placenta. | GCM1 regulation of the expression of syncytin 2 and its cognate receptor MFSD2A in human placenta.
Liang CY, Wang LJ, Chen CP, Chen LF, Chen YH, Chen H. | 12/4/2010 |