| HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma. | HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma.
Kou F, Wu L, Zheng Y, Yi Y, Ji Z, Huang Z, Guo S, Yang L. | 11/14/2023 |
| Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging. | Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
Guo B, Zhang S, Wang S, Zhang H, Fang J, Kang N, Zhen X, Zhang Y, Zhou J, Yan G, Sun H, Ding L, Liu C., Free PMC Article | 11/3/2023 |
| Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease. | Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease.
Ortega MA, De Leon-Oliva D, Garcia-Montero C, Fraile-Martinez O, Boaru DL, Del Val Toledo Lobo M, García-Tuñón I, Royuela M, García-Honduvilla N, Bujan J, Guijarro LG, Alvarez-Mon M, Alvarez-Mon MÁ., Free PMC Article | 05/5/2023 |
| HAT1: Landscape of Biological Function and Role in Cancer. | HAT1: Landscape of Biological Function and Role in Cancer.
Capone V, Della Torre L, Carannante D, Babaei M, Altucci L, Benedetti R, Carafa V., Free PMC Article | 04/19/2023 |
| FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer. | FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.
Sarkar T, Dhar S, Chakraborty D, Pati S, Bose S, Panda AK, Basak U, Chakraborty S, Mukherjee S, Guin A, Jana K, Sarkar DK, Sa G., Free PMC Article | 04/16/2022 |
| Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer. | Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.
Sun Y, Ren D, Zhou Y, Shen J, Wu H, Jin X., Free PMC Article | 02/5/2022 |
| Proteomic analysis identifies novel binding partners of BAP1. | Proteomic analysis identifies novel binding partners of BAP1.
Baas R, J van der Wal F, Bleijerveld OB, van Attikum H, Sixma TK., Free PMC Article | 11/22/2021 |
| Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis. | Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
Yang G, Yuan Y, Yuan H, Wang J, Yun H, Geng Y, Zhao M, Li L, Weng Y, Liu Z, Feng J, Bu Y, Liu L, Wang B, Zhang X., Free PMC Article | 06/5/2021 |
| these data describe a feedforward circuit whereby HAT1 captures acetyl groups on nascent histones and drives H4 production by chromatin binding to support chromatin replication and acetylation. | HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding.
Gruber JJ, Geller B, Lipchik AM, Chen J, Salahudeen AA, Ram AN, Ford JM, Kuo CJ, Snyder MP., Free PMC Article | 02/1/2020 |
| High HAT1 expression is associated with Pancreatic ductal adenocarcinoma. | Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer.
Fan P, Zhao J, Meng Z, Wu H, Wang B, Wu H, Jin X., Free PMC Article | 05/18/2019 |
| In this work, we assessed the relationship between single-nucleotide polymorphisms (SNPs) of KAT1, KAT2 and IDO1 gene encoding, and the risk of depression development. Our study was performed on the DNA isolated from peripheral blood of 281 depressed patients and 236 controls. We genotyped, by using TaqMan probes, four polymorphisms. | Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development.
Wigner P, Czarny P, Synowiec E, Bijak M, Talarowska M, Galecki P, Szemraj J, Sliwinski T. | 02/23/2019 |
| The high-resolution crystal structure of a Hat1p/Hat2p/CoA/H4 peptide complex was solved and it was found that the H4 tail interacts with both Hat1p and Hat2p, by which substrate recruitment is facilitated. It was discovered that H3 N-terminal peptides can bind to the Hat2p WD40 domain. | Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex.
Li Y, Zhang L, Liu T, Chai C, Fang Q, Wu H, Agudelo Garcia PA, Han Z, Zong S, Yu Y, Zhang X, Parthun MR, Chai J, Xu RM, Yang M., Free PMC Article | 07/3/2018 |
| Signalling from Toll-like or TNF-alpha receptors triggers the calcium/calmodulin-dependent protein kinase (CaMK2) to activate histone acetyltransferase-1 (HAT1), which then acetylates the transcriptional regulator PLZF. Acetylation of PLZF promotes the assembly of a repressor complex incorporating HDAC3 and the NF-kappa B p50 subunit that limits the NF-kappa B response. | The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.
Sadler AJ, Suliman BA, Yu L, Yuan X, Wang D, Irving AT, Sarvestani ST, Banerjee A, Mansell AS, Liu JP, Gerondakis S, Williams BR, Xu D. | 07/3/2018 |
| HAT1 is involved in the STAT5 binding to the Bcl2L12 promoter. HAT1 increased the expression of Bcl2L12. Bcl2L12 mediated the effects of HAT1 on suppressing NPC cell apoptosis. Absorption of the HAT1 shRNA plasmid-carrying liposomes induced NPC cell apoptosis. In conclusion, inhibition of HAT1 can induce NPC cell apoptosis via increasing Bcl2L12 expression, which can be a potential therapy for NPC treatment. | Histone acetyltransferase 1 up regulates Bcl2L12 expression in nasopharyngeal cancer cells.
Miao BP, Zhang RS, Yang G, Sun JJ, Tang YY, Liang WF, Liu T, Wen Z, Yang PC, Nie GH. | 07/3/2018 |
| The expression of HAT1 and MYST1, did not differ between drug-sensitive and -resistant cells | Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance.
Miyamoto N, Izumi H, Noguchi T, Nakajima Y, Ohmiya Y, Shiota M, Kidani A, Tawara A, Kohno K. | 07/3/2018 |
| Human histone acetyltransferase 1 (Hat1) acetylates lysine 5 of histone H2A in vivo. | Human histone acetyltransferase 1 (Hat1) acetylates lysine 5 of histone H2A in vivo.
Tafrova JI, Tafrov ST. | 07/3/2018 |
| HAT1 was upregulated in hepatocellular carcinoma.HAT1 acts as an oncogenic protein promoting cell proliferation and inducing cisplatin resistance in hepatocellular carcinoma. | Histone Acetyltransferase 1 Promotes Cell Proliferation and Induces Cisplatin Resistance in Hepatocellular Carcinoma.
Jin X, Tian S, Li P., Free PMC Article | 03/31/2018 |
| Nuclear HDAC2 immunopositivity was significantly higher in actinic cheilitis (AC) when compared with lip squamous cell carcinoma (LSCC). HDAC1 and HAT1 nuclear immunostaining were higher in AC, with no statistical significance. When comparing data with our previous study, we found a positive correlation between HDAC1 X DNMT1/DNMT3b, HDAC2 X DNMT3b, and HAT1 X DNMT1/DNMT3b for certain studied groups. | Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma.
Chrun ES, Modolo F, Vieira D, Borges-Júnior Á, Castro RG, Daniel FI. | 03/17/2018 |
| Data show that PP32 and SET/TAF-Ibeta proteins block HAT1-mediated H4 acetylation. | PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4.
Saavedra F, Rivera C, Rivas E, Merino P, Garrido D, Hernández S, Forné I, Vassias I, Gurard-Levin ZA, Alfaro IE, Imhof A, Almouzni G, Loyola A., Free PMC Article | 12/16/2017 |
| AMPK phosphorylates DNMT1, RBBP7, and HAT1 and increases interactions of DNMT1, RBBP7, and HAT1. | AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.
Marin TL, Gongol B, Zhang F, Martin M, Johnson DA, Xiao H, Wang Y, Subramaniam S, Chien S, Shyy JY., Free PMC Article | 11/18/2017 |
| Results show a novel interaction of the Lsm4 RGG domain with HAT1 and RBBP7, leading to the possibility of a posttranslational modifications network involved in mRNP regulation. | The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.
Arribas-Layton M, Dennis J, Bennett EJ, Damgaard CK, Lykke-Andersen J., Free PMC Article | 06/3/2017 |
| These data indicated that miR-486 aggravate the cholesterol accumulation in THP-1 cells by targeting HAT1. | MiR-486 regulates cholesterol efflux by targeting HAT1.
Liu D, Zhang M, Xie W, Lan G, Cheng HP, Gong D, Huang C, Lv YC, Yao F, Tan YL, Li L, Zheng XL, Tang CK. | 08/13/2016 |
| The expression of HAT1 was higher in the primary Esophageal carcinoma tumors and adjacent tissue as compared to that of the normal esophageal tissue and HAT1 expression was directly correlated with the poor tumor differentiation | RNAi screening identifies HAT1 as a potential drug target in esophageal squamous cell carcinoma.
Xue L, Hou J, Wang Q, Yao L, Xu S, Ge D., Free PMC Article | 05/16/2015 |
| Data indicate that HAT1 is required for homologous recombination in DNA repair. | Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover.
Yang X, Li L, Liang J, Shi L, Yang J, Yi X, Zhang D, Han X, Yu N, Shang Y., Free PMC Article | 09/7/2013 |
| HAT1 differentially impacts nucleosome assembly of H3.1-H4 and H3.3-H4. | Human histone acetyltransferase 1 protein preferentially acetylates H4 histone molecules in H3.1-H4 over H3.3-H4.
Zhang H, Han J, Kang B, Burgess R, Zhang Z., Free PMC Article | 04/28/2012 |