| Hypomorphic mutation of PEX3 with peroxisomal mosaicism reveals the oscillating nature of peroxisome biogenesis coupled with differential metabolic activities. | Hypomorphic mutation of PEX3 with peroxisomal mosaicism reveals the oscillating nature of peroxisome biogenesis coupled with differential metabolic activities.
Takashima S, Fujita H, Toyoshi K, Ohba A, Hirata Y, Shimozawa N, Oh-Hashi K. | 10/29/2022 |
| rs9390123 and rs9399451 influence the DNA repair capacity of lung cancer by regulating PEX3 and PHACTR2AS1 expression instead of PHACTR2. | rs9390123 and rs9399451 influence the DNA repair capacity of lung cancer by regulating PEX3 and PHACTR2‑AS1 expression instead of PHACTR2.
Shi Q, Shi QN, Xu JW, Wang HY, Li YJ, Zhang XX, Fu YH, Tian RH, Jiang R, Liu CC, Sun C. | 02/5/2022 |
| Quantitative Proteomics and Differential Protein Abundance Analysis after the Depletion of PEX3 from Human Cells Identifies Additional Aspects of Protein Targeting to the ER. | Quantitative Proteomics and Differential Protein Abundance Analysis after the Depletion of PEX3 from Human Cells Identifies Additional Aspects of Protein Targeting to the ER.
Zimmermann R, Lang S, Lerner M, Förster F, Nguyen D, Helms V, Schrul B., Free PMC Article | 12/25/2021 |
| studies indicate that Pex3 and Pex19 can also facilitate sorting of certain membrane proteins to other cellular organelles, including the endoplasmic reticulum, lipid droplets, and mitochondria | The peroxisome biogenesis factors Pex3 and Pex19: multitasking proteins with disputed functions.
Jansen RLM, van der Klei IJ. | 12/14/2019 |
| BAG1, CHMP2B, PEX3, and WIPI1 confirmed a strong differential gene expression, in 355 melanoma samples. | WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.
D'Arcangelo D, Giampietri C, Muscio M, Scatozza F, Facchiano F, Facchiano A., Free PMC Article | 03/23/2019 |
| Thus, PEX19 and PEX3 peroxisome biogenesis factors provide an alternative posttranslational route for membrane insertion of the reticulon homology domain-containing proteins, implying that endoplasmic reticulum membrane shaping and peroxisome biogenesis may be coordinated. | The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.
Yamamoto Y, Sakisaka T., Free PMC Article | 12/22/2018 |
| that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis | Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.
Schrul B, Kopito RR., Free PMC Article | 06/10/2017 |
| This insertion of PEX3 into the ER is physiologically relevant. | Human Peroxin PEX3 Is Co-translationally Integrated into the ER and Exits the ER in Budding Vesicles.
Mayerhofer PU, Bañó-Polo M, Mingarro I, Johnson AE., Free PMC Article | 10/22/2016 |
| PEX16 mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and PMP34, via the endoplasmic reticulum | PEX16 contributes to peroxisome maintenance by constantly trafficking PEX3 via the ER.
Aranovich A, Hua R, Rutenberg AD, Kim PK., Free PMC Article | 08/15/2015 |
| Thus within the cell, PEX3 is stabilized by PEX19 preventing PEX3 aggregation. | Association between the intrinsically disordered protein PEX19 and PEX3.
Hattula K, Hirschberg D, Kalkkinen N, Butcher SJ, Ora A., Free PMC Article | 04/18/2015 |
| Mutations in the PEX19-binding domain of PEX3 reduce the affinity for PEX19 and destabilize PEX3. | The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis.
Schmidt F, Dietrich D, Eylenstein R, Groemping Y, Stehle T, Dodt G. | 12/8/2012 |
| The Pex19p peptide contains a characteristic motif, consisting of the leucine triad (Leu18, Leu21, Leu22), and Phe29, which are critical for the Pex3p binding and peroxisome biogenesis. | Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.
Sato Y, Shibata H, Nakatsu T, Nakano H, Kashiwayama Y, Imanaka T, Kato H., Free PMC Article | 01/15/2011 |
| The crystal structure of the cytosolic domain of PEX3 in complex with a PEX19-derived peptide. PEX3 adopts a novel fold that is best described as a large helical bundle. | Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19.
Schmidt F, Treiber N, Zocher G, Bjelic S, Steinmetz MO, Kalbacher H, Stehle T, Dodt G., Free PMC Article | 09/6/2010 |
| The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids. | The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids.
Pinto MP, Grou CP, Fransen M, Sá-Miranda C, Azevedo JE. | 01/21/2010 |
| Pex3p follows the ER-to-peroxisomal route; Pex3p requires Pex16p for ER location but is dispensable for the ER location of Pex16p | Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts.
Toro AA, Araya CA, Córdova GJ, Arredondo CA, Cárdenas HG, Moreno RE, Venegas A, Koenig CS, Cancino J, Gonzalez A, Santos MJ. | 01/21/2010 |
| either one or two tryptophan residues of Pex3p (Trp-104 and Trp-224) are directly involved in binding to Pex19p. | Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interaction.
Sato Y, Shibata H, Nakano H, Matsuzono Y, Kashiwayama Y, Kobayashi Y, Fujiki Y, Imanaka T, Kato H. | 01/21/2010 |
| Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET). | Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET).
Muntau AC, Roscher AA, Kunau WH, Dodt G. | 01/21/2010 |
| Results suggest that PEX3 plays a selective, essential, and direct role in class I peroxisomal membrane protein import as a docking factor for PEX19. | PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.
Fang Y, Morrell JC, Jones JM, Gould SJ., Free PMC Article | 01/21/2010 |
| Data suggest that Pex19p probably functions as a chaperone for membrane proteins and transports them to peroxisomes by anchoring to Pex3p using residues 12-73 and 40-131. | Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation.
Matsuzono Y, Matsuzaki T, Fujiki Y. | 01/21/2010 |