| Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption. | Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
Zhang D, Zhang J, Zhang J, Ji X, Qi Q, Xu J, Pan Y, Liu X, Sun F, Zeng R, Dong L., Free PMC Article | 07/13/2023 |
| The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells. | The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells.
Luo S, Liman N, Li C, Crossman A, Wang ECY, Meylan F, Park JH., Free PMC Article | 03/1/2023 |
| Host versus cell-dependent effects of beta-arrestin 1 expression in prostate tumorigenesis. | Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis.
Adekoya TO, Smith N, Thomas AJ, Lane TS, Burnette N, Rivers EJ, Li Y, Chen XL, Richardson RM., Free PMC Article | 10/2/2021 |
| Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo. | Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.
Jacob N, Kumagai K, Abraham JP, Shimodaira Y, Ye Y, Luu J, Blackwood AY, Castanon SL, Stamps DT, Thomas LS, Gonsky R, Shih DQ, Michelsen KS, Targan SR., Free PMC Article | 05/15/2021 |
| The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens. | The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.
Rodriguez-Barbosa JI, Schneider P, Graca L, Bühler L, Perez-Simon JA, Del Rio ML., Free PMC Article | 02/20/2021 |
| DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus. | DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus.
Shafiei-Jahani P, Hurrell BP, Galle-Treger L, Helou DG, Howard E, Painter J, Lo R, Lewis G, Soroosh P, Akbari O., Free PMC Article | 10/10/2020 |
| Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease. | Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease.
Mavers M, Simonetta F, Nishikii H, Ribado JV, Maas-Bauer K, Alvarez M, Hirai T, Turkoz M, Baker J, Negrin RS., Free PMC Article | 10/3/2020 |
| In contrast to pre-menopausal females, post-menopausal serum levels of TL1A are not significantly elevated and that DR3 expression is not induced on CD14+ monocytes. Murine ovariectomy (OVX) model of estrogen-deficiency revealed that early post-OVX expression of DR3 on CD4+ T cells is significantly elevated suggesting that DR3 and TL1A could play a potentially indirect role in early post-menopausal bone loss. | Oestrogen-deficiency induces bone loss by modulating CD14(+) monocyte and CD4(+) T cell DR3 expression and serum TL1A levels.
Collins FL, Stone MD, Turton J, McCabe LR, Wang ECY, Williams AS., Free PMC Article | 01/4/2020 |
| this study shows that DR3 signaling modulates a multicellular network, encompassing Tregs, T effectors, and innate lymphoid cells, governing disease development and progression in SAMP mice with Crohn's disease-like ileitis | Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis.
Li Z, Buttó LF, Buela KA, Jia LG, Lam M, Ward JD, Pizarro TT, Cominelli F., Free PMC Article | 05/11/2019 |
| in vivo targeting of the TNF superfamily receptor TNFRSF25 using the TL1A-Ig fusion protein, along with IL-2, resulted in transient but massive Treg expansion in donor mice; transplantation of Treg-expanded donor cells facilitated transplant tolerance without GVHD, with complete sparing of graft-versus-malignancy. | Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation.
Wolf D, Barreras H, Bader CS, Copsel S, Lightbourn CO, Pfeiffer BJ, Altman NH, Podack ER, Komanduri KV, Levy RB., Free PMC Article | 03/10/2018 |
| the DR3/TL1A pathway directly enhances human OC formation and resorptive activity, controlling expression and activation of CCL3 and MMP-9. | CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss.
Collins FL, Williams JO, Bloom AC, Singh RK, Jordan L, Stone MD, McCabe LR, Wang ECY, Williams AS., Free PMC Article | 12/23/2017 |
| DR3ko mice were resistant to cellular accumulation within the alveolar passages in acute, but not chronic allergic lung inflammation, and displayed reduced goblet cell hyperplasia in chronic, but not acute allergic lung inflammation | Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation.
Singh RK, Perks WV, Twohig JP, Kidd EJ, Broadley K, Farrow SN, Williams AS, Taylor PR, Wang ECY., Free PMC Article | 11/25/2017 |
| This work describes both a novel function and essential requirement for the DR3/TL1A pathway in acute, resolving, and chronic inflammation in the peritoneal cavity. | Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease.
Perks WV, Singh RK, Jones GW, Twohig JP, Williams AS, Humphreys IR, Taylor PR, Jones SA, Wang ECY., Free PMC Article | 08/19/2017 |
| this study shows that DR3 signaling protects mice from acute dextran sodium sulfate colitis because DR3-/- mice showed more severe mucosal inflammation and increased mortality | A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection.
Jia LG, Bamias G, Arseneau KO, Burkly LC, Wang EC, Gruszka D, Pizarro TT, Cominelli F., Free PMC Article | 08/12/2017 |
| the critical effect of the state of T-cell activation on clinical outcomes after activation of DR3, is reported. | DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease.
Nishikii H, Kim BS, Yokoyama Y, Chen Y, Baker J, Pierini A, Alvarez M, Mavers M, Maas-Bauer K, Pan Y, Chiba S, Negrin RS., Free PMC Article | 08/5/2017 |
| These data identify new roles for DR3 in regulating OB-dependent bone mineral apposition. | Death Receptor 3 (TNFRSF25) Increases Mineral Apposition by Osteoblasts and Region Specific New Bone Formation in the Axial Skeleton of Male DBA/1 Mice.
Collins FL, Williams JO, Bloom AC, Stone MD, Choy E, Wang EC, Williams AS., Free PMC Article | 03/26/2016 |
| Data indicate that death receptor 3 (DR3) depletion gives rise to an increased anti-apoptotic potential. | Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis.
Xu LX, Grimaldo S, Qi JW, Yang GL, Qin TT, Xiao HY, Xiang R, Xiao Z, Li LY, Zhang ZS. | 07/25/2015 |
| these data identify TL1A-DR3 interactions as a novel pathway that promotes Th9 differentiation and pathogenicity. TL1A may be a potential therapeutic target in diseases dependent on IL-9. | The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells.
Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F., Free PMC Article | 06/20/2015 |
| TL1A induces NF-kappaB activation in EC in renal and cardiac tissue from wild type but not DR3 knock-out mice. | TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells.
Wang J, Al-Lamki RS, Zhu X, Liu H, Pober JS, Bradley JR., Free PMC Article | 06/6/2015 |
| Both in supernatant and as purified fusion protein, TL1A-Ig binds to TNFRSF25 transfected--but not untransfected--P815 tumor cells as determined by flow cytometry. | Cloning, expression, and functional characterization of TL1A-Ig.
Khan SQ, Tsai MS, Schreiber TH, Wolf D, Deyev VV, Podack ER. | 03/30/2013 |
| TNFRSF25 agonists expand Tregs in vivo and delay cardiac allograft rejection. | Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival.
Wolf D, Schreiber TH, Tryphonopoulos P, Li S, Tzakis AG, Ruiz P, Podack ER. | 12/8/2012 |
| TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions | TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions.
J Reddy PB, Schreiber TH, Rajasagi NK, Suryawanshi A, Mulik S, Veiga-Parga T, Niki T, Hirashima M, Podack ER, Rouse BT., Free PMC Article | 12/8/2012 |
| This is the first description of DR3 regulating virus-specific T-cell function in vivo and uncovers a critical role for DR3 in mediating antiviral immunity. | The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.
Twohig JP, Marsden M, Cuff SM, Ferdinand JR, Gallimore AM, Perks WV, Al-Shamkhani A, Humphreys IR, Wang EC., Free PMC Article | 10/20/2012 |
| DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor. | DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor.
Al-Lamki RS, Lu W, Finlay S, Twohig JP, Wang EC, Tolkovsky AM, Bradley JR. | 07/28/2012 |
| DR3 facilitates clearance of Salmonella typhimurium in vivo. | Death receptor 3 is essential for generating optimal protective CD4⁺ T-cell immunity against Salmonella.
Buchan SL, Taraban VY, Slebioda TJ, James S, Cunningham AF, Al-Shamkhani A. | 07/21/2012 |