| Circ_0044235 regulates the development of osteoarthritis by the modulation of miR-375/PIK3R3 axis. | Circ_0044235 regulates the development of osteoarthritis by the modulation of miR-375/PIK3R3 axis.
Qian W, Mei K, Zhu L, Chu Y, Lv J, Yun C., Free PMC Article | 04/22/2024 |
| VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas. | VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas.
Lee H, Zhuang L, Gan B., Free PMC Article | 04/18/2024 |
| p55gamma degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning. | p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning.
Li Z, Dai R, Chen M, Huang L, Zhu K, Li M, Zhu W, Li Y, Xie N, Li J, Wang L, Lan F, Cao CM. | 02/16/2024 |
| PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A. | PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A.
Lin W, Wang K, Mo J, Wang L, Song Z, Jiang H, Wang C, Jin C., Free PMC Article | 07/23/2023 |
| PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide Polymorphisms Are Associated with Liver Cancer. | PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide Polymorphisms Are Associated with Liver Cancer.
Wang B, Min W, Zhang W, Liu Q, Guo X, Zhan J, Lei M, Zan Y, Ma Q, Ma H. | 06/1/2023 |
| KMT2C Induced by FABP5P3 Aggravates Keratinocyte Hyperproliferation and Psoriasiform Skin Inflammation by Upregulating the Transcription of PIK3R3. | KMT2C Induced by FABP5P3 Aggravates Keratinocyte Hyperproliferation and Psoriasiform Skin Inflammation by Upregulating the Transcription of PIK3R3.
Huang S, Zhen Y, Yin X, Yang Z, Li X, Wang R, Wen H, Zhong H, Yan J, Sun Q. | 12/24/2022 |
| PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis. | PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis.
Sohn EJ., Free PMC Article | 07/2/2022 |
| LncRNA JHDM1D-AS1 Suppresses MPP + -Induced Neuronal Injury in Parkinson's Disease via miR-134-5p/PIK3R3 Axis. | LncRNA JHDM1D-AS1 Suppresses MPP + -Induced Neuronal Injury in Parkinson's Disease via miR-134-5p/PIK3R3 Axis.
Wang C, Zhang H, Li J. | 04/2/2022 |
| p55PIK deficiency and its NH2-terminal derivative inhibit inflammation and emphysema in COPD mouse model. | p55PIK deficiency and its NH(2)-terminal derivative inhibit inflammation and emphysema in COPD mouse model.
Wang T, Du X, Wang Z, Gu Y, Huang Q, Wu J, Zhan Y, Chen J, Xiao C, Xie J. | 10/9/2021 |
| MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3. | MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3.
Jin W, Liang Y, Li S, Lin G, Liang H, Zhang Z, Zhang W, Nie R., Free PMC Article | 07/24/2021 |
| Inhibition of exosomal miR-24-3p in diabetes restores angiogenesis and facilitates wound repair via targeting PIK3R3. | Inhibition of exosomal miR-24-3p in diabetes restores angiogenesis and facilitates wound repair via targeting PIK3R3.
Xu Y, Ouyang L, He L, Qu Y, Han Y, Duan D., Free PMC Article | 05/15/2021 |
| PIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease. | PIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease.
Ibrahim S, Zhu X, Luo X, Feng Y, Wang J. | 05/1/2021 |
| MicroRNA-29c-3p inhibits osteosarcoma cell proliferation through targeting PIK3R3. | MicroRNA-29c-3p inhibits osteosarcoma cell proliferation through targeting PIK3R3.
Ma HZ, Wang J, Shi J, Zhang W, Zhou DS. | 03/20/2021 |
| miR-29a-3p suppresses hepatic fibrosis pathogenesis by modulating hepatic stellate cell proliferation via targeting PIK3R3 gene expression. | miR-29a-3p suppresses hepatic fibrosis pathogenesis by modulating hepatic stellate cell proliferation via targeting PIK3R3 gene expression.
Fu J, Wu B, Zhong S, Deng W, Lin F. | 02/13/2021 |
| miR-224-5p inhibits proliferation, migration, and invasion by targeting PIK3R3/AKT3 in uveal melanoma. | miR-224-5p inhibits proliferation, migration, and invasion by targeting PIK3R3/AKT3 in uveal melanoma.
Li J, Liu X, Li C, Wang W. | 08/29/2020 |
| HOXD-AS1/miR-186-5p/PIK3R3 is a novel pathway to promote cell migration, invasion, and epithelial-mesenchymal transition in epithelial ovarian cancer | HOXD-AS1 promotes the epithelial to mesenchymal transition of ovarian cancer cells by regulating miR-186-5p and PIK3R3.
Dong S, Wang R, Wang H, Ding Q, Zhou X, Wang J, Zhang K, Long Y, Lu S, Hong T, Ren H, Wong K, Sheng X, Wang Y, Zeng Y., Free PMC Article | 06/15/2019 |
| Database analysis indicates that better disease-free survival in colorectal cancer patients with higher expression of PIK3R3, but there is no significant difference in overall survival. Study in tumor cell lines showed that PIK3R3 could enhance 5-FU induced apoptosis by regulating the expression of thymidine phosphorylase. | PIK3R3 promotes chemotherapeutic sensitivity of colorectal cancer through PIK3R3/NF-kB/TP pathway.
Ibrahim S, Li G, Hu F, Hou Z, Chen Q, Li G, Luo X, Hu J, Feng Y., Free PMC Article | 04/6/2019 |
| PIK3R3 regulates the expression of PPAR-alpha in hepatocytes.The novel PIK3R3-HNF4alpha-PPAR-alpha signaling axis plays a significant role in hepatic lipid metabolism. | PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis.
Yang X, Fu Y, Hu F, Luo X, Hu J, Wang G., Free PMC Article | 01/26/2019 |
| PIK3R3 could promote the metastasis of Pancreatic Cancer by facilitating ZEB1 induced Epithelial-Mesenchymal Transition. | PIK3R3 Promotes Metastasis of Pancreatic Cancer via ZEB1 Induced Epithelial-Mesenchymal Transition.
Peng YP, Zhu Y, Yin LD, Wei JS, Liu XC, Zhu XL, Miao Y. | 08/4/2018 |
| Using case-control study and functional analyses, study have identified SNP rs7536272 A > G, located in the promoter region of PIK3R3, acts as a risk factor of GC through enhancing the transcriptional activity of PIK3R3, contributing to increased expression of PIK3R3. | Genetic variants in PI3K/Akt/mTOR pathway genes contribute to gastric cancer risk.
Ge Y, Liu H, Qiu X, Ma G, Wang H, Du M, Wang M, Zhao Q, Tao G, Chu H, Zhang Z. | 06/23/2018 |
| miR-181a2/181b2 prominently dampened cell-cycle progression, suppressed cell growth, and promoted apoptosis of tumor cells in vitro They also effectively impeded tumor formation and growth in vivo miR-181a2/181b2 exert the tumor suppressor ability by depressing the direct target PIK3R3 (p55gamma) and consequently modulating the PIK3R3/Akt/FoxO signaling pathway | Genetic and Methylation-Induced Loss of miR-181a2/181b2 within chr9q33.3 Facilitates Tumor Growth of Cervical Cancer through the PIK3R3/Akt/FoxO Signaling Pathway.
Mei Q, Li X, Zhang K, Wu Z, Li X, Meng Y, Guo M, Luo G, Fu X, Han W. | 02/10/2018 |
| p55PIK significantly stimulated the expression of AFP by activating NF-kappaB signaling pathway in hepatocellular carcinoma cells. | p55PIK regulates alpha-fetoprotein expression through the NF-κB signaling pathway.
Ye G, Sun G, Cheng Z, Zhang L, Hu K, Xia X, Zhou Y. | 12/2/2017 |
| Study showed that PIK3R3 was a target of miR-365 and its expression was upregulated and inversely correlated with miR-365 expression in glioma tissues. | MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3.
Zhu Y, Zhao H, Rao M, Xu S. | 04/22/2017 |
| p55PIK-PI3K signaling can contribute to imatinib resistance in gastrointestinal stromal tumors by increasing KIT expression. | KIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumors.
Lai S, Wang G, Cao X, Luo X, Wang G, Xia X, Hu J, Wang J., Free PMC Article | 12/17/2016 |
| The proliferation, migration and invasion was decreased in ovarian SKOV3 when HOTAIR or PIK3R3 was silenced. | HOTAIR Promotes Proliferation, Migration, and Invasion of Ovarian Cancer SKOV3 Cells Through Regulating PIK3R3.
Dong L, Hui L., Free PMC Article | 10/1/2016 |