| Liprin-alpha1 contributes to oncogenic MAPK signaling by counteracting ERK activity. | Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity.
Pehkonen H, Filippou A, Väänänen J, Lindfors I, Vänttinen M, Ianevski P, Mäkelä A, Munne P, Klefström J, Toppila-Salmi S, Grénman R, Hagström J, Mäkitie AA, Karhemo PR, Monni O., Free PMC Article | 03/13/2024 |
| High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis. | High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis.
Gao Y, Guan L, Jia R, Xiao W, Han Y, Li Y, Tang P, Yu Z, Zhang H., Free PMC Article | 05/13/2023 |
| Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. | Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
Liang M, Jin G, Xie X, Zhang W, Li K, Niu F, Yu C, Wei Z. | 01/29/2022 |
| Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells. | Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells.
Clapero F, Tortarolo D, Valdembri D, Serini G. | 04/3/2021 |
| We found that PPFIA1 and ALG3 were distinctively overexpressed at the mRNA level in HNSCC tissues compared with normal tissues, they had a significant co-occurrence relationship. Patients without both PPFIA1 and ALG3 mRNA expression alterations had better overall survival and disease/progression-free survival compared with patients with both PPFIA1 and ALG3 alterations. | Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma.
Zhou H, Cao T, Li WP, Wu G. | 01/11/2020 |
| liprin-alpha1 as a novel regulator of CD82 | Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.
Pehkonen H, Lento M, von Nandelstadh P, Filippou A, Grénman R, Lehti K, Monni O., Free PMC Article | 05/11/2019 |
| The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility. | Identification of a membrane-less compartment regulating invadosome function and motility.
Sala K, Raimondi A, Tonoli D, Tacchetti C, de Curtis I., Free PMC Article | 11/24/2018 |
| This study shows that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis, both in vitro and in the developing zebrafish embryo. | PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis.
Mana G, Clapero F, Panieri E, Panero V, Böttcher RT, Tseng HY, Saltarin F, Astanina E, Wolanska KI, Morgan MR, Humphries MJ, Santoro MM, Serini G, Valdembri D., Free PMC Article | 08/25/2018 |
| Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor+/N- breast cancer, but not in estrogen receptor+/N+ or estrogen receptor- patients. | PPFIA1 is upregulated in liver metastasis of breast cancer and is a potential poor prognostic indicator of metastatic relapse.
Yang J, Wu NN, Huang DJ, Luo YC, Huang JZ, He HY, Lu HL, Song WL. | 07/29/2017 |
| These results indicate that liprin-alpha1 localizes to different adhesion and cytoskeletal structures to regulate vimentin intermediate filament network, thereby altering the invasion and growth properties of the cancer cells. | Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery.
Pehkonen H, von Nandelstadh P, Karhemo PR, Lepikhova T, Grenman R, Lehti K, Monni O., Free PMC Article | 03/4/2017 |
| The human tumor cell line MDA-MB-231 expresses liprin-alpha 1 and is able to promote the formation of metastasis in mice. | Effects of the scaffold proteins liprin-α1, β1 and β2 on invasion by breast cancer cells.
Chiaretti S, Astro V, Chiricozzi E, de Curtis I. | 12/17/2016 |
| results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity. | The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.
Liu YC, Couzens AL, Deshwar AR, B McBroom-Cerajewski LD, Zhang X, Puviindran V, Scott IC, Gingras AC, Hui CC, Angers S. | 08/15/2015 |
| Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge | Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration.
Astro V, Chiaretti S, Magistrati E, Fivaz M, de Curtis I. | 08/15/2015 |
| PPFIA1 was frequently co-amplified with the Cyclin D1 gene in oral carcinomas and could present a biomarker as well as a novel target for specific gene therapy. | Amplification of the PPFIA1 gene region on 11q13 in oral squamous cell carcinomas (OSCC).
Blessmann M, Al-Dam A, Hanken H, Assaf AT, Riecke B, Klatt J, Simon R, Sauter G, Heiland M, Kluwe L, Gröbe A. | 10/25/2014 |
| PPFIA1 as a potential functional candidate acute lung injury risk gene | Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.
Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H, Trauma ALI SNP Consortium (TASC) investigators., Free PMC Article | 06/9/2012 |
| The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions | The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.
Taru H, Jin Y., Free PMC Article | 01/7/2012 |
| These results suggest that an increased expression of Liprin-alpha1 in the brain may be associated with human Intractable epilepsy . | Upregulation of liprin-α1 protein in the temporal neocortex of intractable epileptic patients and experimental rats.
Yin H, Wang L, Xiao F, Huang Z, Huang Y, Zhou C, Han Y, Tao S, Yang H, Wang X. | 10/22/2011 |
| Data show that increased levels of liprin-alpha1 affected the localization of inactive, low-affinity integrins, while increasing the average size of beta1 integrin-positive focal adhesions. | Liprin-alpha1 affects the distribution of low-affinity beta1 integrins and stabilizes their permanence at the cell surface.
Asperti C, Pettinato E, de Curtis I. | 04/12/2010 |
| Amplification of both PPFIA1 and CCND1 were significantly associated with high-grade breast cancer phenotype but were unrelated to tumor stage or nodal stage | PPFIA1 and CCND1 are frequently coamplified in breast cancer.
Dancau AM, Wuth L, Waschow M, Holst F, Krohn A, Choschzick M, Terracciano L, Politis S, Kurtz S, Lebeau A, Friedrichs K, Wencke K, Monni O, Simon R. | 02/8/2010 |
| Liprin is an essential regulator of cell motility that contributes to the effectiveness of cell-edge protrusion. | Liprin-alpha1 promotes cell spreading on the extracellular matrix by affecting the distribution of activated integrins.
Asperti C, Astro V, Totaro A, Paris S, de Curtis I. | 01/21/2010 |
| Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, is associated with head and neck squamous cell carcinoma | Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma.
Tan KD, Zhu Y, Tan HK, Rajasegaran V, Aggarwal A, Wu J, Wu HY, Hwang J, Lim DT, Soo KC, Tan P. | 01/21/2010 |
| the interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones | Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.
Ko J, Na M, Kim S, Lee JR, Kim E. | 01/21/2010 |
| liprin binds to ATP-agarose, challenged by free ATP, not by free GTP. Liprin LH region mutations inhibit liprin phosphorylation stabilized association of liprin with ATP-agarose. Suggests that liprin autophosphorylation regulates its association with LAR. | Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation.
Serra-Pagès C, Streuli M, Medley QG., Free PMC Article | 01/21/2010 |
| regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. | Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development.
Hoogenraad CC, Feliu-Mojer MI, Spangler SA, Milstein AD, Dunah AW, Hung AY, Sheng M. | 01/21/2010 |