| Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression. | Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression.
Heo H, Kim HJ, Haam K, Sohn HA, Shin YJ, Go H, Jung HJ, Kim JH, Lee SI, Song KS, Kim MJ, Lee H, Kwon ES, Kim SY, Kim YS, Kim M., Free PMC Article | 05/18/2023 |
| Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27. | Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27.
Wang YX, Huang CY, Chiu HJ, Huang PH, Chien HT, Jwo SH, Liao YC. | 02/13/2023 |
| Mining TCGA and GEO databases for the prediction of poor prognosis in lung adenocarcinoma based on up-regulated expression of TNS4. | Mining TCGA and GEO databases for the prediction of poor prognosis in lung adenocarcinoma based on up-regulated expression of TNS4.
Liu F, Gao X, Liu W, Xue W., Free PMC Article | 10/29/2022 |
| CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA Through Down-Regulation of beta-Catenin in Breast Cancer. | CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA Through Down-Regulation of β-Catenin in Breast Cancer.
Lu X, Zhou B, Cao M, Shao Q, Pan Y, Zhao T., Free PMC Article | 03/12/2022 |
| Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion. | Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion.
Raposo TP, Susanti S, Ilyas M. | 08/14/2021 |
| Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells. | Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells.
Chang CC, Liu YC, Lin CH, Liao YC. | 04/17/2021 |
| Tensin4 promotes invasion and migration of gastric cancer cells via regulating AKT/GSK-3beta/snail signaling pathway. | Tensin4 promotes invasion and migration of gastric cancer cells via regulating AKT/GSK-3β/snail signaling pathway.
Qi X, Sun L, Wan J, Xu R, He S, Zhu X. | 04/3/2021 |
| The authors propose that TNS4 plays a crucial role in CRC tumorigenesis, and that suppression of TNS4 would be an effective therapeutic strategy in treating a subset of cetuximab-refractory CRC patients including KRAS activating mutations. | Whole Transcriptome Analysis Identifies TNS4 as a Key Effector of Cetuximab and a Regulator of the Oncogenic Activity of KRAS Mutant Colorectal Cancer Cell Lines.
Kim S, Kim N, Kang K, Kim W, Won J, Cho J., Free PMC Article | 05/16/2020 |
| analysis of cten force-induced recruitment along keratin network in epithelial cells | Force-induced recruitment of cten along keratin network in epithelial cells.
Cheah JS, Jacobs KA, Heinrich V, Lo SH, Yamada S., Free PMC Article | 04/11/2020 |
| Src is a novel and functionally important target of the Cten signaling pathway and that Cten protein causes post-transcriptional stabilization of Src in promoting EMT and possibly metastasis in colorectal cancer | Cten promotes Epithelial-Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src.
Asiri A, Toss MS, Raposo TP, Akhlaq M, Thorpe H, Alfahed A, Asiri A, Ilyas M. | 02/22/2020 |
| Results suggest that nuclear Cten contributes to cancer cell proliferation. Findings identify a molecular mechanism for regulating Cten protein trafficking in mammalian cells and provide new insights into the dynamics of focal adhesion complexes in health and disease. | Identification of subcellular targeting sequences of Cten reveals its role in cell proliferation.
Hong SY, Shih YP, Lo A, Lo SH., Free PMC Article | 09/14/2019 |
| Cten may play an essential role in mediating TGF-beta1-induced EMT and cell motility and may therefore play a role in metastasis in colorectal cancer. | TGFβ1-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer.
Asiri A, Raposo TP, Alfahed A, Ilyas M., Free PMC Article | 03/16/2019 |
| induction of CTEN reactivates focal adhesion kinase (FAK) Y(397) phosphorylation and disrupts the acini structure. | Downregulation of C-Terminal Tensin-Like Protein (CTEN) Suppresses Prostate Cell Proliferation and Contributes to Acinar Morphogenesis.
Wu WM, Liao YC., Free PMC Article | 01/26/2019 |
| CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells. | CTEN induces epithelial-mesenchymal transition (EMT) and metastasis in non small cell lung cancer cells.
Lu X, Gao J, Zhang Y, Zhao T, Cai H, Zhang T., Free PMC Article | 12/29/2018 |
| Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1. | Clinical Significance of Tensin 4 Gene Expression in Patients with Gastric Cancer.
Sawazaki S, Oshima T, Sakamaki K, Aoyama T, Sato T, Shiozawa M, Yoshikawa T, Rino Y, Imada T, Masuda M., Free PMC Article | 06/16/2018 |
| Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein. | Cten promotes epithelial-mesenchymal transition through the post-transcriptional stabilization of Snail.
Thorpe H, Asiri A, Akhlaq M, Ilyas M. | 12/9/2017 |
| Conclude that in colorectal cancer, Cten is upregulated by EGFR and Kras but downregulated by STAT3. | Multiple pathways regulate Cten in colorectal cancer without a Tensin switch.
Thorpe H, Akhlaq M, Jackson D, Al Ghamdi S, Storr S, Martin S, Ilyas M., Free PMC Article | 07/2/2016 |
| Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma | Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma.
Chan LK, Chiu YT, Sze KM, Ng IO., Free PMC Article | 06/28/2016 |
| Cten expression mediates invasion of human lung cancer cells and is upregulated by epidermal growth factor via STAT3. | C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator of transcription 3.
Bennett DT, Reece TB, Foley LS, Sjoberg A, Meng X, Fullerton DA, Weyant MJ., Free PMC Article | 03/21/2015 |
| Findings indicate that induction of Cten protein expression is a relatively early event in melanoma progression, and that Cten has the potential to serve as a prognostic marker for primary melanoma patients. | C-terminal tensin-like protein is a novel prognostic marker for primary melanoma patients.
Sjoestroem C, Khosravi S, Zhang G, Martinka M, Li G., Free PMC Article | 02/28/2015 |
| Up-regulated cten modulates cell migration induced by FGF2. | Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration.
Hung SY, Shih YP, Chen M, Lo SH., Free PMC Article | 11/8/2014 |
| Significant correlation between MET and TNS4 expression in human colon carcinoma and ovarian carcinoma suggests TNS4 plays a critical role in MET stability in cancer. | Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells.
Muharram G, Sahgal P, Korpela T, De Franceschi N, Kaukonen R, Clark K, Tulasne D, Carpén O, Ivaska J., Free PMC Article | 08/9/2014 |
| CTEN regulates EGFR protein levels through a posttranslational mechanism. | CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation.
Hong SY, Shih YP, Li T, Carraway KL 3rd, Lo SH., Free PMC Article | 02/22/2014 |
| Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. | Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene.
Chen NT, Kuwabara Y, Conley C, Liao YC, Hong SY, Chen M, Shih YP, Chen HW, Hsieh F, Lo SH., Free PMC Article | 06/8/2013 |
| Show an oncogenic role for CTEN in pancreatic cancer through promotion of colony formation and cell motility. | C-terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer.
Al-Ghamdi S, Cachat J, Albasri A, Ahmed M, Jackson D, Zaitoun A, Guppy N, Otto WR, Alison MR, Kindle KB, Ilyas M. | 06/1/2013 |