| PARP10 is highly expressed and associated with inferior outcomes in acute myeloid leukemia. | PARP10 is highly expressed and associated with inferior outcomes in acute myeloid leukemia.
Wang L, Jiang C, Hu D., Free PMC Article | 08/7/2023 |
| The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K(+) channel Kv1.1 through protein kinase C delta. | The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K(+) channel Kv1.1 through protein kinase C delta.
Tian Y, Korn P, Tripathi P, Komnig D, Wiemuth D, Nikouee A, Classen A, Bolm C, Falkenburger BH, Lüscher B, Gründer S., Free PMC Article | 07/10/2021 |
| PLK1/NF-kappaB feedforward circuit antagonizes the mono-ADP-ribosyltransferase activity of PARP10 and facilitates HCC progression. | PLK1/NF-κB feedforward circuit antagonizes the mono-ADP-ribosyltransferase activity of PARP10 and facilitates HCC progression.
Tian L, Yao K, Liu K, Han B, Dong H, Zhao W, Jiang W, Qiu F, Qu L, Wu Z, Zhou B, Zhong M, Zhao J, Qiu X, Zhong L, Guo X, Shi T, Hong X, Lu S. | 12/12/2020 |
| [PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study]. | [PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].
Wu CF, Xiao M, Wang YL, Threadgill MD, Li M, Tang Y, Lin X, Yang L, Li QS, Li X. | 08/22/2020 |
| PARP10 promotes cellular proliferation, and its overexpression alleviates cellular sensitivity to replication stress and fosters the restart of stalled replication forks. In mouse xenograft studies, PARP10 loss reduces the tumorigenesis activity of HeLa cells. Its overexpression results in tumor formation by non-transformed RPE-1 cells. PARP10 may promote cellular transformation by alleviating replication stress. | PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress.
Schleicher EM, Galvan AM, Imamura-Kawasawa Y, Moldovan GL, Nicolae CM., Free PMC Article | 07/13/2019 |
| Study shows that PARP10 is downregulated in intrahepatic metastatic hepatocellular carcinoma. Further results provide evidence that deficiency of PARP10 markedly increased the migration and invasion of tumor cells through regulation of epithelial-mesenchymal transition, and that PARP10 expression inhibited tumor metastasis in vivo. | PARP10 suppresses tumor metastasis through regulation of Aurora A activity.
Zhao Y, Hu X, Wei L, Song D, Wang J, You L, Saiyin H, Li Z, Yu W, Yu L, Ding J, Wu J. | 02/23/2019 |
| PARP10 expression decreased upon fasting, a condition that is characterized by increases in mitochondrial biogenesis. Finally, lower PARP10 expression is associated with increased fatty acid oxidation | PARP10 (ARTD10) modulates mitochondrial function.
Márton J, Fodor T, Nagy L, Vida A, Kis G, Brunyánszki A, Antal M, Lüscher B, Bai P., Free PMC Article | 02/17/2018 |
| ARTD10 plays roles in immunity, metabolism ,apoptosis and DNA damage repair. [review] | Function and regulation of the mono-ADP-ribosyltransferase ARTD10.
Kaufmann M, Feijs KL, Lüscher B. | 03/21/2015 |
| PARP10 binding to PCNA is required for translesion DNA synthesis. | The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance.
Nicolae CM, Aho ER, Vlahos AH, Choe KN, De S, Karras GI, Moldovan GL., Free PMC Article | 06/28/2014 |
| study results show that the interaction between PARP10 and NS1 of H5N1 avian influenza virus can change cell cycle, and PARP10 can affect virus replication | The interaction between the PARP10 protein and the NS1 protein of H5N1 AIV and its effect on virus replication.
Yu M, Zhang C, Yang Y, Yang Z, Zhao L, Xu L, Wang R, Zhou X, Huang P., Free PMC Article | 06/16/2012 |
| alternative catalytic mechanism for PARP10 compared to PARP1 in which the acidic target residue of the substrate functionally substitutes for the catalytic glutamate by using substrate-assisted catalysis to transfer ADP-ribose | Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.
Kleine H, Poreba E, Lesniewicz K, Hassa PO, Hottiger MO, Litchfield DW, Shilton BH, Lüscher B. | 01/21/2010 |
| novel PARP enzyme involved in the control of cell proliferation | PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
Yu M, Schreek S, Cerni C, Schamberger C, Lesniewicz K, Poreba E, Vervoorts J, Walsemann G, Grötzinger J, Kremmer E, Mehraein Y, Mertsching J, Kraft R, Austen M, Lüscher-Firzlaff J, Lüscher B. | 01/21/2010 |
| Overexpression of PARP10 results in loss of cell viability, although down-expression by short hairpin RNA leads to delayed G1 progression and concomitant cell death. | CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10).
Chou HY, Chou HT, Lee SC. | 01/21/2010 |