| MDIG, a 2oxoglutaratedependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer. | MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer.
Geng F, Yang W, Song D, Hou H, Han B, Chen Y, Zhao H., Free PMC Article | 05/28/2022 |
| Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t(4;14) translocation. | Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t(4;14) translocation.
Wang J, Zhu X, Dang L, Jiang H, Xie Y, Li X, Guo J, Wang Y, Peng Z, Wang M, Wang J, Wang S, Li Q, Wang Y, Wang Q, Ye L, Zhang L, Liu Z., Free PMC Article | 04/2/2022 |
| The unfavorable clinical outcome of COVID-19 in smokers is mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks. | The unfavorable clinical outcome of COVID-19 in smokers is mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks.
Shirvaliloo M., Free PMC Article | 02/5/2022 |
| The bioinformatics analysis of RIOX2 gene in lung adenocarcinoma and squamous cell carcinoma. | The bioinformatics analysis of RIOX2 gene in lung adenocarcinoma and squamous cell carcinoma.
Sun B, Zhao H., Free PMC Article | 01/15/2022 |
| The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via EGFR and HIF-1alpha signaling. | The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via EGFR and HIF-1α signaling.
Zhou H, Geng F, Chen Y, Du J, Zhang X, Liu B, Song D, Hou H, Zhao H. | 11/6/2021 |
| Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism. | Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism.
Zhang Q, Wadgaonkar P, Xu L, Thakur C, Fu Y, Bi Z, Qiu Y, Almutairy B, Zhang W, Stemmer P, Chen F., Free PMC Article | 08/7/2021 |
| Pathological and Prognostic Indications of the mdig Gene in Human Lung Cancer. | Pathological and Prognostic Indications of the mdig Gene in Human Lung Cancer.
Shi J, Thakur C, Zhao Y, Li Y, Nie L, Zhang Q, Bi Z, Fu Y, Wadgaonkar P, Almutairy B, Xu L, Zhang W, Qiu Y, Rice M, Cui H, Chen F., Free PMC Article | 07/3/2021 |
| Mdig promotes oncogenic gene expression through antagonizing repressive histone methylation markers. | Mdig promotes oncogenic gene expression through antagonizing repressive histone methylation markers.
Zhang Q, Thakur C, Fu Y, Bi Z, Wadgaonkar P, Xu L, Liu Z, Liu W, Wang J, Kidder BL, Chen F., Free PMC Article | 04/24/2021 |
| ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma. | ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.
Zhang L, Huo Q, Ge C, Zhao F, Zhou Q, Chen X, Tian H, Chen T, Xie H, Cui Y, Yao M, Li H, Li J. | 11/21/2020 |
| Mina53 may play an important role in the occurrence of hepatocellular carcinoma and participate in the process of tumor growth as well as invasion and metastasis. | [Significance of expression of Myc-induced nuclear antigen 53 in hepatocellular carcinoma and its relationship with patient prognosis].
Ye DX, Zhou X, Yang Q, Hu XY, Li H, Xiang FG. | 08/1/2020 |
| MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response. | MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response.
Xuan F, Huang M, Zhao E, Cui H., Free PMC Article | 12/14/2019 |
| Data indicate that in vitro histone demethylase MINA53 (MINA53) preferentially demethylates the histone substrate, H3K36me3. | A CRISPR/Cas9 screen identifies the histone demethylase MINA53 as a novel HIV-1 latency-promoting gene (LPG).
Huang H, Kong W, Jean M, Fiches G, Zhou D, Hayashi T, Que J, Santoso N, Zhu J., Free PMC Article | 12/7/2019 |
| Mina53 regulates the differentiation and proliferation of leukemia cells. | Mina53 regulates the differentiation and proliferation of leukemia cells.
Zhou L, Zhang T, Zhu Q, Zhang P, Yu L, Shen B, Yi W, Qiu M, Zhu C. | 11/30/2019 |
| RIOX2 transcripts were overexpressed in renal cell tumor subtypes compared to renal normal tissues. Higher RIOX2 transcript levels were associated with metastasis. | SETDB2 and RIOX2 are differentially expressed among renal cell tumor subtypes, associating with prognosis and metastization.
Ferreira MJ, Pires-Luís AS, Vieira-Coimbra M, Costa-Pinheiro P, Antunes L, Dias PC, Lobo F, Oliveira J, Gonçalves CS, Costa BM, Henrique R, Jerónimo C., Free PMC Article | 12/22/2018 |
| our findings revealed that Mina53 was an important indicator of prognosis in patients with stage III colorectal cancer treated with adjuvant chemotherapy. | Mina53 nuclear localization is an important indicator of prognosis in patients with colorectal cancer after adjuvant chemotherapy.
Fujino S, Kinugasa T, Sudo T, Mizobe T, Yoshida T, Yoshida N, Ohchi T, Tajiri K, Yuge K, Nagasu S, Katagiri M, Akagi Y. | 10/13/2018 |
| Results indicate that mdig can inhibit the phosphorylation of GSK-3beta and promote the phosphorylation and destabilization of beta-catenin, in order to suppress the expression of slug, snail, and ZEB1 and the occurrence of EMT, and thereby inhibit the invasion and metastasis of non-small cell lung cancer (NSCLC). | Mdig suppresses epithelial-mesenchymal transition and inhibits the invasion and metastasis of non‑small cell lung cancer via regulating GSK-3β/β-catenin signaling.
Geng F, Jiang Z, Song X, Zhou H, Zhao H. | 07/28/2018 |
| mdig directly interacts with c-myc and JAK1 in multiple myeloma (MM) cell lines, which contributes to hyperactivation of the IL-6-JAK-STAT3 signaling important for the pathogenesis of MM. | Proteomic Characterization of the World Trade Center dust-activated mdig and c-myc signaling circuit linked to multiple myeloma.
Wu K, Li L, Thakur C, Lu Y, Zhang X, Yi Z, Chen F., Free PMC Article | 04/28/2018 |
| MDIG overexpression substantially promoted hepatocellular carcinoma cell proliferation, cell migration and spreading, whereas knockdown of MDIG would reverse above-mentioned effect. | Dysfunction of IKZF1/MYC/MDIG axis contributes to liver cancer progression through regulating H3K9me3/p21 activity.
Huo Q, Ge C, Tian H, Sun J, Cui M, Li H, Zhao F, Chen T, Xie H, Cui Y, Yao M, Li J., Free PMC Article | 02/3/2018 |
| Findings reveal the role of MINA in glioblastoma initiation and progression by controlling the cell-cycle progression through transcriptionally regulating cyclin and CDK expression via the demethylation of H3K9me3. | MINA controls proliferation and tumorigenesis of glioblastoma by epigenetically regulating cyclins and CDKs via H3K9me3 demethylation.
Huang MY, Xuan F, Liu W, Cui HJ. | 09/9/2017 |
| Data suggest that mineral dust-induced gene protein (mdig) accomplishes its functions on chromatin, DNA repair and cell growth through interacting with the partner proteins. | The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair.
Wang W, Lu Y, Stemmer PM, Zhang X, Bi Y, Yi Z, Chen F., Free PMC Article | 08/6/2016 |
| Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. | Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome.
Guo T, Chung JH, Wang T, McDonald-McGinn DM, Kates WR, Hawuła W, Coleman K, Zackai E, Emanuel BS, Morrow BE., Free PMC Article | 03/26/2016 |
| in lung cancer tissues, upregulation of mdig expression accompanies with the downregulation of p27(KIP1) expression and in bronchial stump | Mdig, a lung cancer-associated gene, regulates cell cycle progression through p27(KIP1).
Ma D, Guo D, Li W, Zhao H. | 03/5/2016 |
| Mina53 can be used as a marker for pancreatic cancer | Potential effects of Mina53 on tumor growth in human pancreatic cancer.
Tan XP, Dong WG, Zhang Q, Yang ZR, Lei XF, Ai MH., Free PMC Article | 09/5/2015 |
| Mina: a Th2 response regulator meets TGFbeta. | Mina: a Th2 response regulator meets TGFβ.
Pillai MR, Lian S, Bix M., Free PMC Article | 08/1/2015 |
| Increased expression of mdig in cancer tissues. | Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion.
Yu M, Sun J, Thakur C, Chen B, Lu Y, Zhao H, Chen F., Free PMC Article | 09/27/2014 |