| PHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA. | PHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA.
Chang Z, Jia Y, Gao M, Song L, Zhang W, Zhao R, Yu D, Liu X, Li J, Qin Y., Free PMC Article | 03/14/2024 |
| De novo PHF5A variants are associated with craniofacial abnormalities, developmental delay, and hypospadias. | De novo PHF5A variants are associated with craniofacial abnormalities, developmental delay, and hypospadias.
Harms FL, Dingemans AJM, Hempel M, Pfundt R, Bierhals T, Casar C, Müller C, Niermeijer JF, Fischer J, Jahn A, Hübner C, Majore S, Agolini E, Novelli A, van der Smagt J, Ernst R, van Binsbergen E, Mancini GMS, van Slegtenhorst M, Barakat TS, Wakeling EL, Kamath A, Downie L, Pais L, White SM, de Vries BBA, Kutsche K. | 11/13/2023 |
| PHF5A is a potential diagnostic, prognostic, and immunological biomarker in pan-cancer. | PHF5A is a potential diagnostic, prognostic, and immunological biomarker in pan-cancer.
Ding N, Li M, Zhao X., Free PMC Article | 10/25/2023 |
| PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation. | PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation.
Liu C, Li G, Zheng S, She L, Lu S, Wang Y, Huang D, Zhang X, Sun L, Liu Y, Qiu Y., Free PMC Article | 07/13/2023 |
| [PHF5A Promotes Proliferation and Migration of Non-Small Cell Lung Cancer by Regulating of PI3K/AKT Pathway]. | [PHF5A Promotes Proliferation and Migration of Non-Small Cell Lung Cancer
by Regulating of PI3K/AKT Pathway].
Wang H, Liu F, Bai C, Xu N., Free PMC Article | 02/22/2023 |
| Research progress and therapeutic prospect of PHF5A acting as a new target for malignant tumors. | Research progress and therapeutic prospect of PHF5A acting as a new target for malignant tumors.
Li M, Cheng Q, Wang X, Yang Y., Free PMC Article | 01/11/2023 |
| PHF5A Contributes to the Maintenance of the Cancer Stem-like Phenotype in Non-Small Cell Lung Cancer by Regulating Histone Deacetylase 8. | PHF5A Contributes to the Maintenance of the Cancer Stem-like Phenotype in Non-Small Cell Lung Cancer by Regulating Histone Deacetylase 8.
Yang Y, Li M, Zhou X, Wang W, Shao Y, Yao J, Wang X. | 07/23/2022 |
| Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition. | Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition.
Begum NA, Haque F, Stanlie A, Husain A, Mondal S, Nakata M, Taniguchi T, Taniguchi H, Honjo T., Free PMC Article | 11/13/2021 |
| we validated that PHF5A played an oncogenic role via AS in LUAD and suggested that PHF5A might serve as a potential drug target with a promising anticancer therapeutic effect. | PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing.
Mao S, Li Y, Lu Z, Che Y, Huang J, Lei Y, Wang Y, Liu C, Wang X, Zheng S, Sun N, He J., Free PMC Article | 07/4/2020 |
| Acetylation of PHF5A modulates stress responses and colorectal carcinogenesis through alternative splicing-mediated upregulation of KDM3A. | Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A.
Wang Z, Yang X, Liu C, Li X, Zhang B, Wang B, Zhang Y, Song C, Zhang T, Liu M, Liu B, Ren M, Jiang H, Zou J, Liu X, Zhang H, Zhu WG, Yin Y, Zhang Z, Gu W, Luo J. | 01/18/2020 |
| Study identified PHD finger protein 5A (PHF5A) as a key splicing factor involved in breast cancer progression. PHF5A expression was frequently upregulated in breast cancer and correlated with poor survival, and knockdown of PHF5A significantly suppressed cell proliferation, migration, and tumor formation. PHF5A was required for SF3b spliceosome stability and linked the complex to histones. | PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression.
Zheng YZ, Xue MZ, Shen HJ, Li XG, Ma D, Gong Y, Liu YR, Qiao F, Xie HY, Lian B, Sun WL, Zhao HY, Yao L, Zuo WJ, Li DQ, Wang P, Hu X, Shao ZM. | 08/3/2019 |
| PHF5A plays an indispensable role in progressive effect of NF-kappaB pathway in HCC. | Knockdown of PHF5A Inhibits Migration and Invasion of HCC Cells via Downregulating NF-κB Signaling.
Yang Q, Zhang J, Xu S, Jia C, Meng W, Tang H, Zhang X, Zhang Y, Fu B., Free PMC Article | 06/1/2019 |
| The data suggest for the first time that PHF5A is an oncoprotein that contributes to LAC progression by regulating multiple signaling pathways, and may constitute a prognostic factor and potential new therapeutic target in NSCLC. | PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma.
Yang Y, Zhu J, Zhang T, Liu J, Li Y, Zhu Y, Xu L, Wang R, Su F, Ou Y, Wu Q., Free PMC Article | 05/11/2019 |
| PHF5A-SF3B1 forms a central node for binding to splicing modulators | Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Teng T, Tsai JH, Puyang X, Seiler M, Peng S, Prajapati S, Aird D, Buonamici S, Caleb B, Chan B, Corson L, Feala J, Fekkes P, Gerard B, Karr C, Korpal M, Liu X, T Lowe J, Mizui Y, Palacino J, Park E, Smith PG, Subramanian V, Wu ZJ, Zou J, Yu L, Chicas A, Warmuth M, Larsen N, Zhu P., Free PMC Article | 12/22/2018 |
| We found PHF5A, a component of the U2 snRNP mRNA splicing factor, blocks expression from recombinant Adeno-associated virus vectors | An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.
Schreiber CA, Sakuma T, Izumiya Y, Holditch SJ, Hickey RD, Bressin RK, Basu U, Koide K, Asokan A, Ikeda Y., Free PMC Article | 05/7/2016 |
| PHF5A facilitates recognition of exons with unusual C-rich 3' splice sites in thousands of essential genes | Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A.
Hubert CG, Bradley RK, Ding Y, Toledo CM, Herman J, Skutt-Kakaria K, Girard EJ, Davison J, Berndt J, Corrin P, Hardcastle J, Basom R, Delrow JJ, Webb T, Pollard SM, Lee J, Olson JM, Paddison PJ., Free PMC Article | 07/6/2013 |
| The molecular and genetic research in this paper is performed on mouse but the paper identifies and discusses homologues found in human genomic sequence databases. | Identification and characterization of a novel murine multigene family containing a PHD-finger-like motif.
Trappe R, Ahmed M, Gläser B, Vogel C, Tascou S, Burfeind P, Engel W. | 10/18/2004 |