| The role of lamin B2 in human diseases. | The role of lamin B2 in human diseases.
Li Y, Zhu J, Yu Z, Li H, Jin X. | 05/30/2023 |
| Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycleassociated protein 3. | Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3.
Ji J, Li H, Chen J, Wang W., Free PMC Article | 07/16/2022 |
| LMNB2 is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma. | LMNB2 is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma.
Kong W, Wu Z, Yang M, Zuo X, Yin G, Chen W. | 11/27/2021 |
| LMNB2 promotes the progression of colorectal cancer by silencing p21 expression. | LMNB2 promotes the progression of colorectal cancer by silencing p21 expression.
Dong CH, Jiang T, Yin H, Song H, Zhang Y, Geng H, Shi PC, Xu YX, Gao H, Liu LY, Zhou L, Zhang ZH, Song J., Free PMC Article | 10/16/2021 |
| Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy. | Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy.
Parry DA, Martin CA, Greene P, Marsh JA, Genomics England Research Consortium, Blyth M, Cox H, Donnelly D, Greenhalgh L, Greville-Heygate S, Harrison V, Lachlan K, McKenna C, Quigley AJ, Rea G, Robertson L, Suri M, Jackson AP., Free PMC Article | 07/10/2021 |
| Lamin B2 promotes the malignant phenotype of non-small cell lung cancer cells by upregulating dimethylation of histone 3 lysine 9. | Lamin B2 promotes the malignant phenotype of non-small cell lung cancer cells by upregulating dimethylation of histone 3 lysine 9.
Zhang MY, Han YC, Han Q, Liang Y, Luo Y, Wei L, Yan T, Yang Y, Liu SL, Wang EH. | 02/6/2021 |
| our studies strongly implicate an overarching role for Lamin B2 in the maintenance of nuclear architecture since loss of Lamin B2 relieves the spatial positional constraints required for maintaining conserved localization of aneuploid chromosome territories in the interphase nucleus. | Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus.
Ranade D, Koul S, Thompson J, Prasad KB, Sengupta K., Free PMC Article | 11/25/2017 |
| Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia. | Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia.
Damiano JA, Afawi Z, Bahlo M, Mauermann M, Misk A, Arsov T, Oliver KL, Dahl HH, Shearer AE, Smith RJ, Hall NE, Mahmood K, Leventer RJ, Scheffer IE, Muona M, Lehesjoki AE, Korczyn AD, Herrmann H, Berkovic SF, Hildebrand MS., Free PMC Article | 04/9/2016 |
| Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. | Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform.
Elkhatib R, Longepied G, Paci M, Achard V, Grillo JM, Levy N, Mitchell MJ, Metzler-Guillemain C. | 11/21/2015 |
| Treating normal human fibroblasts with farnesyltransferase inhibitors causes the accumulation of unprocessed lamin B2 and lamin A and a decrease in mature lamin B1 | Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.
Adam SA, Butin-Israeli V, Cleland MM, Shimi T, Goldman RD., Free PMC Article | 09/28/2013 |
| Mutation in LMNB2 gene is associated with partial lipodystrophy. | A Chinese patient with acquired partial lipodystrophy caused by a novel mutation with LMNB2 gene.
Gao J, Li Y, Fu X, Luo X. | 07/28/2012 |
| Studies indicate that the lamin-binding proteins implicated in laminopathies include lamin B2 and nuclear envelope proteins. | Laminopathies and lamin-associated signaling pathways.
Maraldi NM, Capanni C, Cenni V, Fini M, Lattanzi G. | 08/6/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| These findings indicate that a lamin dimer principally has the freedom for a "combinatorial" head-to-tail association with all types of lamins, a property that might be of significant importance for the assembly of the nuclear lamina. | Characterization of the head-to-tail overlap complexes formed by human lamin A, B1 and B2 "half-minilamin" dimers.
Kapinos LE, Schumacher J, Mücke N, Machaidze G, Burkhard P, Aebi U, Strelkov SV, Herrmann H. | 03/15/2010 |
| Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW. | 01/28/2009 |
| the lamin B2 origin adopts a structure partly composed of intramolecular TAT triads | Noncanonical DNA elements in the lamin B2 origin of DNA replication.
Kusic J, Kojic S, Divac A, Stefanovic D. | 01/21/2010 |
| This analysis reveals the modular structure of the lamin B2 origin and supports the idea that sequence elements close to the replication start site play an important role in origin activation. | Modular structure of the human lamin B2 replicator.
Paixão S, Colaluca IN, Cubells M, Peverali FA, Destro A, Giadrossi S, Giacca M, Falaschi A, Riva S, Biamonti G., Free PMC Article | 01/21/2010 |
| lamin B was essential for the formation of the mitotic matrix that tethers a number of spindle assembly factors; propose that lamin B is a structural component of the spindle matrix that promotes microtubule assembly and organization in mitosis | A mitotic lamin B matrix induced by RanGTP required for spindle assembly.
Tsai MY, Wang S, Heidinger JM, Shumaker DK, Adam SA, Goldman RD, Zheng Y. | 01/21/2010 |
| Three new rare heterozygous mutations are the first reported for LMNB2 and are the first reported among patients with acquired partial lipodystrophy. | Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy.
Hegele RA, Cao H, Liu DM, Costain GA, Charlton-Menys V, Rodger NW, Durrington PN., Free PMC Article | 01/21/2010 |
| human lamin B(2) is indeed synthesized as a longer version than previously reported, because it contains these additional 20 amino acids | Identification of a novel, highly variable amino-terminal amino acid sequence element in the nuclear intermediate filament protein lamin B(2) from higher vertebrates.
Schumacher J, Reichenzeller M, Kempf T, Schnölzer M, Herrmann H. | 01/21/2010 |
| The proteins bound in vivo at the LMNB2 replication origin were investigated along the cell cycle. | Localization of proteins bound to a replication origin of human DNA along the cell cycle.
Abdurashidova G, Danailov MB, Ochem A, Triolo G, Djeliova V, Radulescu S, Vindigni A, Riva S, Falaschi A., Free PMC Article | 01/21/2010 |
| the distinctive ensemble of heterotypic lamin interactions in a particular cell type affects the stability of the lamin polymer | The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths.
Schirmer EC, Gerace L. | 01/21/2010 |
| analysis of protein-DNA interactions at the human lamin B2 replication origin | In vitro protein-DNA interactions at the human lamin B2 replication origin.
Stefanovic D, Stanojcic S, Vindigni A, Ochem A, Falaschi A. | 01/21/2010 |
| The human DNA replication origin, located in the lamin B2 gene, interacts with the DNA topoisomerases I and II in a cell cycle-modulated manner. | Functional interactions of DNA topoisomerases with a human replication origin.
Abdurashidova G, Radulescu S, Sandoval O, Zahariev S, Danailov MB, Demidovich A, Santamaria L, Biamonti G, Riva S, Falaschi A., Free PMC Article | 01/21/2010 |