| Impact of Histone Lysine Methyltransferase SUV4-20H2 on Cancer Onset and Progression with Therapeutic Potential. | Impact of Histone Lysine Methyltransferase SUV4-20H2 on Cancer Onset and Progression with Therapeutic Potential.
Papadaki S, Piperi C., Free PMC Article | 03/14/2024 |
| Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis. | Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis.
Zeng B, Wan R, Chang K, Li J, Zhang X, Shi G, Ye D, Xu F., Free PMC Article | 03/5/2024 |
| Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma. | Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.
Ryu TY, Lee J, Kang Y, Son MY, Kim DS, Lee YS, Kim MY, Cho HS. | 05/23/2023 |
| Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression. | Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression.
Boonsanay V, Mosa MH, Looso M, Weichenhan D, Ceteci F, Pudelko L, Lechel A, Michel CS, Künne C, Farin HF, Plass C, Greten FR., Free PMC Article | 02/4/2023 |
| Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET. | Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET.
Pal AS, Agredo A, Lanman NA, Son J, Sohal IS, Bains M, Li C, Clingerman J, Gates K, Kasinski AL., Free PMC Article | 05/7/2022 |
| H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells. | H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells.
Kurup JT, Han Z, Jin W, Kidder BL., Free PMC Article | 02/2/2021 |
| The analysis of human pancreatic cancer biopsies was concordant with these findings, because high levels of SUV420H2 correlated with a loss of epithelial characteristics in progressively invasive cancer. Together, these data indicate that SUV420H2 is an upstream epigenetic regulator of epithelial/mesenchymal state control. | SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.
Viotti M, Wilson C, McCleland M, Koeppen H, Haley B, Jhunjhunwala S, Klijn C, Modrusan Z, Arnott D, Classon M, Stephan JP, Mellman I., Free PMC Article | 12/22/2018 |
| Study provides evidence that Suv420h2 controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis. | Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation.
Khani F, Thaler R, Paradise CR, Deyle DR, Kruijthof-de Julio M, Galindo M, Gordon JA, Stein GS, Dudakovic A, van Wijnen AJ., Free PMC Article | 11/26/2017 |
| Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes. | Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.
Brustel J, Kirstein N, Izard F, Grimaud C, Prorok P, Cayrou C, Schotta G, Abdelsamie AF, Déjardin J, Méchali M, Baldacci G, Sardet C, Cadoret JC, Schepers A, Julien E., Free PMC Article | 09/30/2017 |
| The sequences surrounding both methylation sites do not fit to the specificity profile of SUV4-20H1. | Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and methylation of novel substrates.
Weirich S, Kudithipudi S, Jeltsch A. | 06/24/2017 |
| Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2. | lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress.
Zhao Z, Dammert MA, Grummt I, Bierhoff H. | 12/17/2016 |
| One of the most downregulated genes in response to SUV420H2 expression was the Src substrate, tensin-3, a focal adhesion protein that contributes to cancer cell migration. | SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3.
Shinchi Y, Hieda M, Nishioka Y, Matsumoto A, Yokoyama Y, Kimura H, Matsuura S, Matsuura N. | 08/15/2015 |
| The crystal structure of SUV420H2 was used to characterize substrate selectivity and product specificity. | Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.
Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J. | 01/18/2014 |
| SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation | Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation.
Tsang LW, Hu N, Underhill DA., Free PMC Article | 07/9/2011 |
| data indicate that H4K20me3 invokes gene repression by antagonizing hMOF-mediated H4K16Ac | SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation.
Kapoor-Vazirani P, Kagey JD, Vertino PM., Free PMC Article | 06/4/2011 |
| The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20] | Preferential dimethylation of histone H4 lysine 20 by Suv4-20.
Yang H, Pesavento JJ, Starnes TW, Cryderman DE, Wallrath LL, Kelleher NL, Mizzen CA., Free PMC Article | 01/21/2010 |
| occurrence of an unusual TG 3' splice site in intron 5 | Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M., Free PMC Article | 10/9/2007 |
| The decrease in trimethylation of lysine 20 of histone H4 in breast cancer cells was accompanied by diminished expression of Suv4-20h2 histone methyltransferase. | Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins.
Tryndyak VP, Kovalchuk O, Pogribny IP. | 01/21/2010 |