| The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis. | The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.
Caratis F, Opiełka M, Hausmann M, Velasco-Estevez M, Rojek B, de Vallière C, Seuwen K, Rogler G, Karaszewski B, Rutkowska A., Free PMC Article | 03/31/2024 |
| Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-kappaB pathways. | Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways.
Zhang K, Zhang MX, Meng XX, Zhu J, Wang JJ, He YF, Li YH, Zhao SC, Shi ZM, Zheng LN, Han T, Hong W., Free PMC Article | 12/1/2023 |
| Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory bowel disease. | Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory bowel disease.
Li G, Lin J, Gao X, Su H, Lin R, Gao H, Feng Z, Wu H, Feng B, Zuo K, Li Y, Wu W, Fang L, Liu Z., Free PMC Article | 09/29/2023 |
| GPR65 inhibits human trophoblast cell adhesion through upregulation of MYLK and downregulation of fibronectin via cAMP-ERK signaling in a low pH environment. | GPR65 inhibits human trophoblast cell adhesion through upregulation of MYLK and downregulation of fibronectin via cAMP-ERK signaling in a low pH environment.
Mao J, Feng Y, Zheng Y, Gao Y, Zhang L, Sun X, Wu Y, Zhu X, Ma F., Free PMC Article | 09/28/2023 |
| MicroRNAs combined with the TLR4/TDAG8 mRNAs and proinflammatory cytokines are biomarkers for the rapid diagnosis of sepsis. | MicroRNAs combined with the TLR4/TDAG8 mRNAs and proinflammatory cytokines are biomarkers for the rapid diagnosis of sepsis.
Xu X, Bu B, Tian H, Wu R, Yang J., Free PMC Article | 10/1/2022 |
| IBD-associated G protein-coupled receptor 65 variant compromises signalling and impairs key functions involved in inflammation. | IBD-associated G protein-coupled receptor 65 variant compromises signalling and impairs key functions involved in inflammation.
Mercier V, Boucher G, Devost D, Bourque K, Alikashani A, Beauchamp C, Bitton A, Foisy S, Goyette P, Charron G, Hébert TE, Rioux JD., Free PMC Article | 04/30/2022 |
| GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2. | GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2.
Lin R, Wu W, Chen H, Gao H, Wu X, Li G, He Q, Lu H, Sun M, Liu Z., Free PMC Article | 04/9/2022 |
| Multilocus evaluation of genetic predictors of multiple sclerosis. | Multilocus evaluation of genetic predictors of multiple sclerosis.
Timasheva Y, Nasibullin TR, Tuktarova IA, Erdman VV, Galiullin TR, Zaplakhova OV, Bakhtiiarova KZ. | 12/11/2021 |
| Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes. | Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes.
Sayama K, Yuki K, Sugata K, Fukagawa S, Yamamoto T, Ikeda S, Murase T., Free PMC Article | 09/4/2021 |
| The evolution and mechanism of GPCR proton sensing. | The evolution and mechanism of GPCR proton sensing.
Rowe JB, Kapolka NJ, Taghon GJ, Morgan WM, Isom DG., Free PMC Article | 08/28/2021 |
| T-cell death-associated gene 8 accelerates atherosclerosis by promoting vascular smooth muscle cell proliferation and migration. | T-cell death-associated gene 8 accelerates atherosclerosis by promoting vascular smooth muscle cell proliferation and migration.
Chen LD, Zhu WT, Cheng YY, Li ZH, Chen YQ, Yuan ZW, Lin CY, Jing DD, Liu ZQ, Yan PK. | 04/13/2021 |
| Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors. | Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
Klatt W, Wallner S, Brochhausen C, Stolwijk JA, Schreml S., Free PMC Article | 01/23/2021 |
| The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model. | The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model.
Sato K, Tobo A, Mogi C, Tobo M, Yamane N, Tosaka M, Tomura H, Im DS, Okajima F., Free PMC Article | 01/16/2021 |
| this study shows that genetic polymorphisms of G protein-coupled receptor 65 gene are associated with ankylosing spondylitis in a Chinese Han population | Genetic polymorphisms of G protein-coupled receptor 65 gene are associated with ankylosing spondylitis in a Chinese Han population: A case-control study.
Yuan Y, Ma Y, Zhang X, Han R, Hu X, Yang J, Wang M, Guan SY, Pan G, Xu SQ, Jiang S, Pan F. | 06/29/2019 |
| Panic disorder (PD) patients appear to display polymorphisms in the ACCN gene and elevated levels of TDAG8 mRNA. [systematic review, meta-analysis ] | The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies.
Quagliato LA, Freire RC, Nardi AE., Free PMC Article | 03/16/2019 |
| we confirmed a significant association between the rare homozygote rs8005161 TT genotype and a diagnosis of ulcerative colitis. Our study did not identify biochemical changes in individuals with various genotypes of rs8005161, however we identified a lower activation of RhoA upon an acidic pH shift in inflammatory bowel disease patients. | The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.
Tcymbarevich IV, Eloranta JJ, Rossel JB, Obialo N, Spalinger M, Cosin-Roger J, Lang S, Kullak-Ublick GA, Wagner CA, Scharl M, Seuwen K, Ruiz PA, Rogler G, de Vallière C, Misselwitz B, Swiss IBD Cohort Study Group., Free PMC Article | 02/2/2019 |
| GPR65 is overexpressed in glioblastoma and its high expression predicts unfavorable clinical outcome for patients. | Overexpression of G-protein-coupled receptors 65 in glioblastoma predicts poor patient prognosis.
Wang HX, Chen YH, Zhou JX, Hu XY, Tan C, Yan Y, Huang QL, Shen JY, Xu HC, Li F, Gong ZY, Xu T, Chen JX. | 01/19/2019 |
| TDAG8 functions as a contextual tumor suppressor down-regulated in hematological malignancies. | Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies.
Justus CR, Sanderlin EJ, Dong L, Sun T, Chi JT, Lertpiriyapong K, Yang LV., Free PMC Article | 07/21/2018 |
| Study results suggest greater T cell death associated gene-8 (TDAG8) expression in patients with panic disorder compared to healthy subjects, and directly link TDAG8 expression and the severity of the panic disorder symptoms | Acid-sensing T cell death associated gene-8 receptor expression in panic disorder.
Strawn JR, Vollmer LL, McMurray KMJ, Mills JA, Mossman SA, Varney ST, Schroeder HK, Sah R., Free PMC Article | 07/14/2018 |
| this study establishes a role for GPR65 in inflammatory bowel disease susceptibility and identify lysosomal dysfunction as a potentially causative element in pathogenesis | Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.
Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ., Free PMC Article | 09/16/2017 |
| TDAG8 expression is decreased by more than 50%. | Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8.
Li Z, Dong L, Dean E, Yang LV., Free PMC Article | 04/26/2014 |
| GPR65 is a regulator upstream of MMP3, which is regulated by proton-sensing G-protein-coupled receptors | Identification of GPR65, a novel regulator of matrix metalloproteinases using high through-put screening.
Xu H, Chen X, Huang J, Deng W, Zhong Q, Yue C, Wang P, Huang Z. | 08/31/2013 |
| Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk. | Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk.
Ryder C, McColl K, Zhong F, Distelhorst CW., Free PMC Article | 11/17/2012 |
| Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes and macrophages. | Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro.
Onozawa Y, Fujita Y, Kuwabara H, Nagasaki M, Komai T, Oda T. | 09/15/2012 |
| These results support the hypothesis that TDAG8 enhances tumor development by promoting adaptation to the acidic environment to enhance cell survival/proliferation. | The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor.
Ihara Y, Kihara Y, Hamano F, Yanagida K, Morishita Y, Kunita A, Yamori T, Fukayama M, Aburatani H, Shimizu T, Ishii S., Free PMC Article | 11/27/2010 |