| Study reveals how the LNX1 RING domain is structurally and mechanistically dependent on other motifs for its E3 ligase activity, and describes how dimeric LNX1 recruits ubiquitin (Ub)-loaded Ubc13 for Ub transfer via E3 ligase-mediated catalysis. | Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1.
Nayak D, Sivaraman J. | 05/11/2019 |
| study provided the evidences that LNX1 signaling plays important roles in regulating the stemness of colon cancer cells | Suppression of cancer stemness by upregulating Ligand-of-Numb protein X1 in colorectal carcinoma.
Ma L, Wang L, Shan Y, Nafees M, Ihab E, Zhang R, Wang F, Yin W., Free PMC Article | 12/30/2017 |
| LNX was closely related to human gliomas and suggested it plays an important role in gliomas by notch signaling. | [Molecular cloning and identify expression of the novel human LNX gene in gliomas].
Chen JX, Lu YC, Hu GH, Sun KH, Luo C, Zhao W, Wu H, Xie Y. | 06/29/2013 |
| LNX1-mediated ubiquitination and degradation of PBK inhibited cell proliferation and enhanced sensitivity to doxorubicin-induced apoptosis. | Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase.
Guo Z, Song E, Ma S, Wang X, Gao S, Shao C, Hu S, Jia L, Tian R, Xu T, Gao Y. | 03/2/2013 |
| identify and confirm six novel LNX1 binding partners: KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2 and PBK, and suggest that LNX1 functions as a signalling scaffold. | Biochemical and computational analysis of LNX1 interacting proteins.
Wolting CD, Griffiths EK, Sarao R, Prevost BC, Wybenga-Groot LE, McGlade CJ., Free PMC Article | 05/19/2012 |
| The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever. | The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever.
Mehraj V, Boucherit N, Ben Amara A, Capo C, Bonatti S, Mege JL, Mottola G, Ghigo E. | 05/5/2012 |
| LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis | Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis.
D'Agostino M, Tornillo G, Caporaso MG, Barone MV, Ghigo E, Bonatti S, Mottola G. | 03/31/2012 |
| Down-regulation of LNX could result in cell cycle arrest in G0/G1 phase through inhibition of beta-catenin, MAPK, NFkappaB, c-Myc-dependent pathway and activation of p53, TGF-beta-dependent pathway. | A global genomic view on LNX siRNA-mediated cell cycle arrest.
Zheng D, Gu S, Li Y, Ji C, Xie Y, Mao Y. | 07/30/2011 |
| LNX and RhoC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1. | LNX (Ligand of Numb-protein X) interacts with RhoC, both of which regulate AP-1-mediated transcriptional activation.
Zheng D, Sun Y, Gu S, Ji C, Zhao W, Xie Y, Mao Y. | 10/4/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.
Burgner D, Davila S, Breunis WB, Ng SB, Li Y, Bonnard C, Ling L, Wright VJ, Thalamuthu A, Odam M, Shimizu C, Burns JC, Levin M, Kuijpers TW, Hibberd ML, International Kawasaki Disease Genetics Consortium., Free PMC Article | 02/11/2009 |
| Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas. | Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors.
Blom T, Roselli A, Tanner M, Nupponen NN, Blom T, Roselli A, Tanner M, Nupponen NN. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors.
Blom T, Roselli A, Tanner M, Nupponen NN, Blom T, Roselli A, Tanner M, Nupponen NN. | 11/5/2008 |
| A direct interaction between ErbB2 and mouse LNX1 was identified, suggesting that LNX1 may be involved in neuregulin-1/ErbB signaling in perisynaptic Schwann cells. | LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2.
Young P, Nie J, Wang X, McGlade CJ, Rich MM, Feng G. | 05/6/2008 |
| The tyrosine phosphorylation of the LDNPAY sequence motif in mouse LNX could generate a binding site for the phosphorylation-dependent binding of other PTB domain-containing proteins. | The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.
Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR, McGlade CJ. | 05/6/2008 |
| Describes various glioblastoma multiforms containing the amplicon on chromosomal segment 4q12, including the LNX1 gene. | Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme.
Holtkamp N, Ziegenhagen N, Malzer E, Hartmann C, Giese A, von Deimling A., Free PMC Article | 05/5/2008 |
| The interaction of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src. | c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1.
Weiss A, Baumgartner M, Radziwill G, Dennler J, Moelling K. | 01/21/2010 |
| identifed ligand of Numb protein X as an Np9-interacting partner; findings point to the possibility that Np9 affects tumorigenesis through the LNX/Numb/Notch pathway | Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.
Armbruester V, Sauter M, Roemer K, Best B, Hahn S, Nty A, Schmid A, Philipp S, Mueller A, Mueller-Lantzsch N., Free PMC Article | 01/21/2010 |
| The presence of multiple protein binding domains involved in signal transduction and interaction with Numb and SKIP suggested an important role for LNX in tumorogenesis. | Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas.
Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, Xie Y, Lu Y. | 01/21/2010 |