| Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells. | Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.
Mu N, Wang Y, Li X, Du Z, Wu Y, Su M, Wang Y, Sun X, Su L, Liu X., Free PMC Article | 10/10/2023 |
| Induced pluripotent stem cells established from a female patient with Xq22 deletion confirm that BEX2 escapes from X-chromosome inactivation. | Induced pluripotent stem cells established from a female patient with Xq22 deletion confirm that BEX2 escapes from X-chromosome inactivation.
Yamamoto-Shimojima K, Osawa M, Saito MK, Yamamoto T. | 12/25/2021 |
| BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma. | BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma.
Fukushi D, Shibuya-Takahashi R, Mochizuki M, Fujimori H, Kogure T, Sugai T, Iwai W, Wakui Y, Abue M, Murakami K, Nakamura Y, Yasuda J, Yamaguchi K, Sugamura K, Shibata C, Katayose Y, Satoh K, Tamai K., Free PMC Article | 11/27/2021 |
| BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma. | BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma.
Tamai K, Nakamura-Shima M, Shibuya-Takahashi R, Kanno SI, Yasui A, Mochizuki M, Iwai W, Wakui Y, Abue M, Yamamoto K, Miura K, Mizuma M, Unno M, Kawamura S, Sato I, Yasuda J, Yamaguchi K, Sugamura K, Satoh K., Free PMC Article | 05/1/2021 |
| MiR-370 could downregulate BEX2 gene. | MicroRNA-370 functions as a tumor suppressor in hepatocellular carcinoma via inhibition of the MAPK/JNK signaling pathway by targeting BEX2.
Wang X, Zhu W, Xu C, Wang F, Zhu X, Sun Y, Guo Y, Fu X, Zhang Y, Zang Y. | 03/14/2020 |
| The study reveals that BEX2 promotes colorectal cancer cell proliferation via the JNK/c-Jun pathway, suggesting BEX2 as a potential candidate target for the treatment of CRC. | BEX2 promotes tumor proliferation in colorectal cancer.
Hu Y, Xiao Q, Chen H, He J, Tan Y, Liu Y, Wang Z, Yang Q, Shen X, Huang Y, Yuan Y, Ding K., Free PMC Article | 11/11/2017 |
| Bex2 affects the invasion and migration ability of glioma cells by regulating beta-catenin | Β-catenin is involved in Bex2 down-regulation induced glioma cell invasion/migration inhibition.
Nie E, Zhang X, Xie S, Shi Q, Hu J, Meng Q, Zhou X, Yu R. | 03/21/2015 |
| Bex2 overexpression promoted cell migration and invasion in glioma cell lines. | Bex2 is critical for migration and invasion in malignant glioma cells.
Zhou X, Xu X, Meng Q, Hu J, Zhi T, Shi Q, Yu R. | 10/19/2013 |
| Bex2 may be an important player during the development of glioma | Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway.
Zhou X, Meng Q, Xu X, Zhi T, Shi Q, Wang Y, Yu R. | 03/23/2013 |
| Both BEX2 and INI1/hSNF5 mainly localized in cell nucleus. | [BEX2 regulates cell cycle through the interaction with INI1/hSNF5].
Han QY, Fan YH, Wang YL, Zhang SD, Han CY. | 09/22/2012 |
| BEX2 overexpression was associated with breast cancer. | A feedback loop between BEX2 and ErbB2 mediated by c-Jun signaling in breast cancer.
Naderi A, Liu J, Francis GD. | 12/24/2011 |
| BEX2 has a functional interplay with c-Jun and p65/RelA in breast cancer. | BEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer.
Naderi A, Liu J, Hughes-Davies L., Free PMC Article | 08/2/2010 |
| These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins. | Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia.
Röhrs S, Dirks WG, Meyer C, Marschalek R, Scherr M, Slany R, Wallace A, Drexler HG, Quentmeier H., Free PMC Article | 02/8/2010 |
| BEX2 is implicated in oligodendroglioma biology. | Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression.
Le Mercier M, Fortin S, Mathieu V, Roland I, Spiegl-Kreinecker S, Haibe-Kains B, Bontempi G, Decaestecker C, Berger W, Lefranc F, Kiss R., Free PMC Article | 01/21/2010 |
| Correlation between BEX2 expression and mixed lineage leukemia chromosomal aberrations are shown in the cell lines. | Epigenetic regulation of brain expressed X-linked-2, a marker for acute myeloid leukemia with mixed lineage leukemia rearrangements.
Fischer C, Drexler HG, Reinhardt J, Zaborski M, Quentmeier H. | 01/21/2010 |
| hBex2 may act as a specific regulator during embryonic development by modulating the transcriptional activity of a novel E-box sequence-binding complex that contains hBex2, LMO2, NSCL2 and LDB1. | Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex.
Han C, Liu H, Liu J, Yin K, Xie Y, Shen X, Wang Y, Yuan J, Qiang B, Liu YJ, Peng X., Free PMC Article | 01/21/2010 |
| a NGF/BEX2/NF-kappaB pathway is involved in regulating apoptosis in breast cancer cells and in modulating response to tamoxifen in primary tumors | BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines.
Naderi A, Teschendorff AE, Beigel J, Cariati M, Ellis IO, Brenton JD, Caldas C. | 01/21/2010 |
| Two novel brain expressed genes, BEX1 and BEX2 are identified; they are silenced in all glioma specimens and exhibit extensive promoter hypermethylation. | Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma.
Foltz G, Ryu GY, Yoon JG, Nelson T, Fahey J, Frakes A, Lee H, Field L, Zander K, Sibenaller Z, Ryken TC, Vibhakar R, Hood L, Madan A. | 01/21/2010 |