| PP1 bound on spinophilin, a close homolog of neurabin and another major synaptic PP1 anchoring protein, does not play a role in long term depression [LTD] induction, which suggests that neurabin plays a privileged role in nanodomain targeting of PP1 in LTD induction. | Distinct Roles of Protein Phosphatase 1 Bound on Neurabin and Spinophilin and Its Regulation in AMPA Receptor Trafficking and LTD Induction.
Gao J, Hu XD, Yang H, Xia H., Free PMC Article | 02/9/2019 |
| Data show that the PP1:spinophilin holoenzyme is dynamic in solution, which allows for an increased capture radius of spinophilin and is likely important for its biological role. | Flexibility in the PP1:spinophilin holoenzyme.
Ragusa MJ, Allaire M, Nairn AC, Page R, Peti W., Free PMC Article | 03/19/2011 |
| The spinophilin interactome was charaterized in subcellular fractions solubilized from adult rodent striatum. | Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach.
Baucum AJ 2nd, Jalan-Sakrikar N, Jiao Y, Gustin RM, Carmody LC, Tabb DL, Ham AJ, Colbran RJ., Free PMC Article | 09/6/2010 |
| selective targeting of PP1gamma1 to F-actin by neurabins 1& 2 in intact cells requires both the canonical PP1-binding motif and an auxiliary PP1gamma1-selectivity determinant | Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin.
Carmody LC, Baucum AJ 2nd, Bass MA, Colbran RJ., Free PMC Article | 01/21/2010 |
| Mutation of the Cdk5 phosphorylation site reduces the phenotypic consequences of Neurabin-I overexpression both in vitro and in vivo | Neurabin-I is phosphorylated by Cdk5: implications for neuronal morphogenesis and cortical migration.
Causeret F, Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M., Free PMC Article | 01/21/2010 |
| study determined the structure of the neurabin SAM domain by solution state nuclear magnetic resonance spectroscopy | Structural characterization of the neurabin sterile alpha motif domain.
Ju T, Ragusa MJ, Hudak J, Nairn AC, Peti W. | 01/21/2010 |
| NrbI-targeted PP1, in response to distinct synaptic activities, regulates the synaptic trafficking of specific AMPAR subunits | Differential regulation of AMPA receptor trafficking by neurabin-targeted synaptic protein phosphatase-1 in synaptic transmission and long-term depression in hippocampus.
Hu XD, Huang Q, Yang X, Xia H., Free PMC Article | 01/21/2010 |
| recruit specific isoforms of protein phosphatase-1 catalytic subunits | The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.
Terry-Lorenzo RT, Carmody LC, Voltz JW, Connor JH, Li S, Smith FD, Milgram SL, Colbran RJ, Shenolikar S. | 01/21/2010 |
| Postsynaptic actin-bound neurabin-I-PP1 complex regulates synaptic transmission and bidirectional changes in hippocampal plasticity. | Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity.
Hu XD, Huang Q, Roadcap DW, Shenolikar SS, Xia H. | 01/21/2010 |
| there is a novel PP1gamma1-selective interaction domain in neurabin that may allow for selective regulation and/or subcellular targeting of PP1 isoforms | A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin.
Carmody LC, Bauman PA, Bass MA, Mavila N, DePaoli-Roach AA, Colbran RJ. | 01/21/2010 |
| N-terminal F-actin-binding domain dictated neurabin I localization at actin cytoskeleton and promoted disassembly of stress fibers (neurabin I) | Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology.
Oliver CJ, Terry-Lorenzo RT, Elliott E, Bloomer WA, Li S, Brautigan DL, Colbran RJ, Shenolikar S., Free PMC Article | 01/21/2010 |