| RNase 7 Inhibits Uropathogenic Escherichia coli-Induced Inflammation in Bladder Cells under a High-Glucose Environment by Regulating the JAK/STAT Signaling Pathway. | RNase 7 Inhibits Uropathogenic Escherichia coli-Induced Inflammation in Bladder Cells under a High-Glucose Environment by Regulating the JAK/STAT Signaling Pathway.
Ho CH, Liao PW, Fan CK, Liu SP, Cheng PC., Free PMC Article | 05/21/2022 |
| Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections. | Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections.
Pierce KR, Eichler T, Mosquera Vasquez C, Schwaderer AL, Simoni A, Creacy S, Hains DS, Spencer JD., Free PMC Article | 12/18/2021 |
| Involvement of RNase 7 in the malignant potential of oral squamous cell carcinoma cells. | Involvement of RNase 7 in the malignant potential of oral squamous cell carcinoma cells.
Neopane P, Kurashige Y, Yoshida K, Uehara O, Paudel D, Morikawa T, Sato J, Saitoh M, Abiko Y. | 05/22/2021 |
| RNase 7 Promotes Sensing of Self-DNA by Human Keratinocytes and Activates an Antiviral Immune Response. | RNase 7 Promotes Sensing of Self-DNA by Human Keratinocytes and Activates an Antiviral Immune Response.
Kopfnagel V, Dreyer S, Baumert K, Stark M, Harder J, Hofmann K, Kleine M, Buch A, Sodeik B, Werfel T. | 03/13/2021 |
| RAE1 mediated ZEB1 expression promotes epithelial-mesenchymal transition in breast cancer. | RAE1 mediated ZEB1 expression promotes epithelial-mesenchymal transition in breast cancer.
Oh JH, Lee JY, Yu S, Cho Y, Hur S, Nam KT, Kim MH., Free PMC Article | 10/10/2020 |
| RNase 7 has a role in kidney and bladder host defense against uropathogenic Escherichia coli | Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection.
Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD., Free PMC Article | 05/2/2020 |
| RNase 7 may function as important effector molecule to control the growth of corynebacteria on human skin | RNase 7 participates in cutaneous innate control of Corynebacterium amycolatum.
Walter S, Rademacher F, Kobinger N, Simanski M, Gläser R, Harder J., Free PMC Article | 07/13/2019 |
| RNase 7 exhibits potent immunomodulatory functions and supports the efficient recognition of microbial infections by human skin-infiltrating pDCs. | RNase 7 Strongly Promotes TLR9-Mediated DNA Sensing by Human Plasmacytoid Dendritic Cells.
Kopfnagel V, Wagenknecht S, Harder J, Hofmann K, Kleine M, Buch A, Sodeik B, Werfel T. | 05/4/2019 |
| These data suggest that the induction of RNase 7 in response to Mycobacterium tuberculosis could have a role in anti-mycobacterial immunity. | RNase 7 but not psoriasin nor sPLA2-IIA associates with Mycobacterium tuberculosis during airway epithelial cell infection.
Torres-Juarez F, Touqui L, Leon-Contreras J, Rivas-Santiago C, Enciso-Moreno JA, Hernández-Pando R, Rivas-Santiago B. | 09/29/2018 |
| RNase 7 has immunomodulatory functions on TH2 cells and decreases the production of TH2 cytokines in the skin. | RNase 7 downregulates TH2 cytokine production by activated human T cells.
Kopfnagel V, Wagenknecht S, Brand L, Zeitvogel J, Harder J, Hofmann K, Kleine M, Werfel T. | 06/23/2018 |
| Our results indicate that RNase 7 is an important factor released by keratinocytes to control the growth of P. aeruginosa on the skin surface. | The role of RNase 7 in innate cutaneous defense against Pseudomonas aeruginosa.
Rademacher F, Simanski M, Schröder L, Mildner M, Harder J. | 03/3/2018 |
| Insulin and PI3K/AKT signaling are essential for RNase 7 expression and increased infection risks in diabetic patients may be secondary to suppressed RNase 7 production. | Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract.
Eichler TE, Becknell B, Easterling RS, Ingraham SE, Cohen DM, Schwaderer AL, Hains DS, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD., Free PMC Article | 10/21/2017 |
| This article provides an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases. [review] | RNase 7 in Cutaneous Defense.
Rademacher F, Simanski M, Harder J., Free PMC Article | 01/14/2017 |
| RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria. | An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract.
Spencer JD, Schwaderer AL, Eichler T, Wang H, Kline J, Justice SS, Cohen DM, Hains DS., Free PMC Article | 02/14/2015 |
| epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression upon infection with Trichophytum rubrum | Infection of keratinocytes with Trichophytum rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression.
Firat YH, Simanski M, Rademacher F, Schröder L, Brasch J, Harder J., Free PMC Article | 01/17/2015 |
| RNase 7 is an antimicrobial protein that plays an important role in the innate immune defense system of human epithelia. | RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin.
Harder J, Schroder JM. | 11/3/2014 |
| Suggest that RNase 7 may function as antimicrobial peptide with a role in the differentiation and development of the primitive epidermis. | Prenatal human skin expresses the antimicrobial peptide RNase 7.
Schuster C, Gläser R, Fiala C, Eppel W, Harder J, Schröder JM, Elbe-Bürger A., Free PMC Article | 12/14/2013 |
| Levels of psoriasin, RNase 7 and hBD-3 expression - assessed by immunohistochemistry - varied between different body localisations. | Differential expression and in vivo secretion of the antimicrobial peptides psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin.
Wittersheim M, Cordes J, Meyer-Hoffert U, Harder J, Hedderich J, Gläser R. | 11/16/2013 |
| the influence of STAT3 on the IL-17A/IFN-gamma -mediated RNase 7 induction | IL-17A and IFN-γ synergistically induce RNase 7 expression via STAT3 in primary keratinocytes.
Simanski M, Rademacher F, Schröder L, Schumacher HM, Gläser R, Harder J., Free PMC Article | 10/19/2013 |
| RNase 7 expression is increased in the urinary tract with infection and has antibacterial activity against uropathogens at micromolar concentrations. | Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract.
Spencer JD, Schwaderer AL, Wang H, Bartz J, Kline J, Eichler T, DeSouza KR, Sims-Lucas S, Baker P, Hains DS., Free PMC Article | 09/28/2013 |
| a complex relationship between tear induction of miR-762, its modulation of innate defense genes, and P. aeruginosa internalization | MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2.
Mun J, Tam C, Chan G, Kim JH, Evans D, Fleiszig S., Free PMC Article | 08/31/2013 |
| RNASE7 prevents staphylococcal skin infections | RNase 7 protects healthy skin from Staphylococcus aureus colonization.
Simanski M, Dressel S, Gläser R, Harder J. | 01/1/2011 |
| These findings suggest that antimicrobial peptides found at high baseline levels in healthy skin, such as RNase 7, confer protection against Staphylococcus aureus infection of the skin. | Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin.
Zanger P, Holzer J, Schleucher R, Steffen H, Schittek B, Gabrysch S. | 01/21/2010 |
| data indicate that RNase 7 contributes to the E. faecium-killing activity of skin extracts and suggest an important role for RNase 7 in the protection of human skin against E. faecium colonization | RNase 7 contributes to the cutaneous defense against Enterococcus faecium.
Köten B, Simanski M, Gläser R, Podschun R, Schröder JM, Harder J., Free PMC Article | 01/21/2010 |
| proteases contribute indirectly to the defense function of the stratum corneum by releasing the RNase inhibitor mediated inhibition of RNase 5 and RNase 7. | Degradation by stratum corneum proteases prevents endogenous RNase inhibitor from blocking antimicrobial activities of RNase 5 and RNase 7.
Abtin A, Eckhart L, Mildner M, Ghannadan M, Harder J, Schröder JM, Tschachler E. | 01/21/2010 |