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    KISS1R KISS1 receptor [ Homo sapiens (human) ]

    Gene ID: 84634, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Kisspeptin signalling and its correlation with placental ultrastructure and clinical outcomes in pregnant South African women with obesity and gestational diabetes.

    Kisspeptin signalling and its correlation with placental ultrastructure and clinical outcomes in pregnant South African women with obesity and gestational diabetes.
    Musa E, Salazar-Petres E, Vatish M, Levitt N, Sferruzzi-Perri AN, Matjila MJ.

    10/10/2024
    Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration.

    Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration.
    Balraj P, Ambhore NS, Ramakrishnan YS, Borkar NA, Banerjee P, Reza MI, Varadharajan S, Kumar A, Pabelick CM, Prakash YS, Sathish V.,

    09/26/2024
    The role of placental kisspeptin in trophoblast invasion and migration: an assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta.

    The role of placental kisspeptin in trophoblast invasion and migration: an assessment in Kiss1r knockout mice, BeWo cell lines and human term placenta.
    Panting EN, Weight JH, Sartori JA, Coall DA, Smith JT.

    08/1/2024
    Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.

    Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.
    Shen S, Wang D, Liu H, He X, Cao Y, Chen J, Li S, Cheng X, Xu HE, Duan J.

    07/31/2024
    Physiological and pathological roles of locally expressed kisspeptin and KISS1R in the endometrium.

    Physiological and pathological roles of locally expressed kisspeptin and KISS1R in the endometrium.
    Zhang J, Jin L, Kong L, Nie L, Yuan D.

    07/24/2023
    Kisspeptin-10 Mitigates alpha-Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner.

    Kisspeptin-10 Mitigates α-Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner.
    Simon C, Soga T, Parhar I., Free PMC Article

    04/15/2023
    The Kisspeptin and Kisspeptin receptor in follicular microenvironment: is that really necessary for oocyte maturation and fertilisation?

    The Kisspeptin and Kisspeptin receptor in follicular microenvironment: is that really necessary for oocyte maturation and fertilisation?
    Kuspinar G, Cakır C, Kasapoglu I, Saribal S, Oral B, Budak F, Uncu G, Avcı B.

    01/14/2023
    Inverse Correlation of KISS1 and KISS1R Expression in Triple-negative Breast Carcinomas from African American Women.

    Inverse Correlation of KISS1 and KISS1R Expression in Triple-negative Breast Carcinomas from African American Women.
    Qasim M, Ricks-Santi LJ, Naab TJ, Rajack F, Beyene D, Abbas M, Kassim OO, Copeland RL, Kanaan Y., Free PMC Article

    11/5/2022
    Associations of the KiSS-1 and GPR54 genetic polymorphism with polycystic ovary syndrome in Yunnan, China.

    Associations of the KiSS-1 and GPR54 genetic polymorphism with polycystic ovary syndrome in Yunnan, China.
    Zhao T, Zhang Q, Xiao X, Tao X, Gao M, He W, Wu X, Yuan T.

    10/8/2022
    Neuroendocrine Regulation of Stress-Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway.

    Neuroendocrine Regulation of Stress-Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway.
    Zhang S, Yu F, Che A, Tan B, Huang C, Chen Y, Liu X, Huang Q, Zhang W, Ma C, Qian M, Liu M, Qin J, Du B., Free PMC Article

    05/14/2022
    Evaluation of KISS1 Receptor Gene Expression in Egyptian Female Patients with Breast Cancer.

    Evaluation of KISS1 Receptor Gene Expression in Egyptian Female Patients with Breast Cancer.
    Gomaa SH, Zaki MA, Sultan MH, Dwedar FI, Elzain Zidan EH., Free PMC Article

    04/2/2022
    KP-10/Gpr54 attenuates rheumatic arthritis through inactivating NF-kappaB and MAPK signaling in macrophages.

    KP-10/Gpr54 attenuates rheumatic arthritis through inactivating NF-κB and MAPK signaling in macrophages.
    Wang D, Wu Z, Zhao C, Yang X, Wei H, Liu M, Zhao J, Qian M, Li Z, Xiao J.

    03/5/2022
    KISS1R polymorphism rs587777844 (Tyr313His) is linked to female infertility.

    KISS1R polymorphism rs587777844 (Tyr313His) is linked to female infertility.
    Siahpoosh Z, Farsimadan M, Pazhohan M, Vaziri H, Mahmoudi Gomari M.

    01/22/2022
    Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion.

    Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion.
    Berthon A, Settas N, Delaney A, Giannakou A, Demidowich A, Faucz FR, Seminara SB, Chen ME, Stratakis CA., Free PMC Article

    09/4/2021
    Formation of Kiss1R/GPER Heterocomplexes Negatively Regulates Kiss1R-mediated Signalling through Limiting Receptor Cell Surface Expression.

    Formation of Kiss1R/GPER Heterocomplexes Negatively Regulates Kiss1R-mediated Signalling through Limiting Receptor Cell Surface Expression.
    Ke R, Lok SIS, Singh K, Chow BKC, Janovjak H, Lee LTO.

    06/19/2021
    G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer.

    G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer.
    Dragan M, Nguyen MU, Guzman S, Goertzen C, Brackstone M, Dhillo WS, Bech PR, Clarke S, Abbara A, Tuck AB, Hess DA, Pine SR, Zong WX, Wondisford FE, Su X, Babwah AV, Bhattacharya M., Free PMC Article

    03/13/2021
    MKRN3 and KISS1R mutations in precocious and early puberty.

    MKRN3 and KISS1R mutations in precocious and early puberty.
    Pagani S, Calcaterra V, Acquafredda G, Montalbano C, Bozzola E, Ferrara P, Gasparri M, Villani A, Bozzola M., Free PMC Article

    03/6/2021
    Identification of KISS1R gene mutations in disorders of non-obstructive azoospermia in the northeast population of China.

    Identification of KISS1R gene mutations in disorders of non-obstructive azoospermia in the northeast population of China.
    Geng D, Zhang H, Liu X, Fei J, Jiang Y, Liu R, Wang R, Zhang G., Free PMC Article

    02/2/2021
    Association of Polymorphisms in the Kisspeptin/GPR54 Pathway Genes With Risk of Early Puberty in Chinese Girls.

    Association of Polymorphisms in the Kisspeptin/GPR54 Pathway Genes With Risk of Early Puberty in Chinese Girls.
    Li D, Wu Y, Cheng J, Liu L, Li X, Chen D, Huang S, Wen Y, Ke Y, Yao Y, Su Z, Zhou L.

    01/9/2021
    variants in KISS1, KISS1R, and GNRHR genes can modulate hormone levels and reproductive outcomes

    Variants in the Kisspeptin-GnRH Pathway Modulate the Hormonal Profile and Reproductive Outcomes.
    Martins Trevisan C, Naslavsky MS, Monfardini F, Wang J, Zatz M, Peluso C, Pellegrino R, Mafra F, Hakonarson H, Ferreira FM, Nakaya H, Christofolini DM, Montagna E, Crandall KA, Barbosa CP, Bianco B.

    06/20/2020
    based on the mutations found in KISS1 and KISS1R, this review provides insights into the precise mechanism of kisspeptin and the kisspeptin/Kiss1R pathway in the reproductive axis and in puberty.

    Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies.
    Ke R, Ma X, Lee LTO.

    06/6/2020
    Serum kisspeptin levels are higher in Sri Lankan women with PCOS [ Polycystic ovary syndrome ]manifesting from adolescence compared with controls regardless of body mass index. We propose serum kisspeptin concentration as a useful marker to recognize PCOS that manifests from adolescence.

    Polycystic ovary syndrome (PCOS) and kisspeptin - A Sri Lankan study.
    Umayal B, Jayakody SN, Chandrasekharan NV, Wijesundera WS, Wijeyaratne CN., Free PMC Article

    05/23/2020
    The expression levels of KISS1R and KISS1 were significantly up-regulated in granulosa lutein cells from women with polycystic ovary syndrome.

    Increased Expression of KISS1 and KISS1 Receptor in Human Granulosa Lutein Cells-Potential Pathogenesis of Polycystic Ovary Syndrome.
    Hu KL, Zhao H, Min Z, He Y, Li T, Zhen X, Ren Y, Chang HM, Yu Y, Li R.

    05/9/2020
    The expression of KISS1 and KISS1R was examined in prostate cancer tissue specimens after radical prostatectomy. A higher expression of KISS1 and KISS1R was shown in patients with localized tumors (Stage </=IIb) compared to patients with advanced (Stage >/=III) tumor.

    Expression of Kisspeptin (KISS1) and its Receptor GPR54 (KISS1R) in Prostate Cancer.
    Xoxakos I, Petraki C, Msaouel P, Armakolas A, Grigorakis A, Stefanakis S, Koutsilieris M.

    02/29/2020
    Our study highlights the importance of the KISS1R signaling, in gonadotropin-releasing hormone neurons, in the control of reproductive function. Additionally, our data suggests a complex central and peripheral metabolic control of puberty, through the hypothalamic KISS1R signaling.

    Nonstop mutation in the Kisspeptin 1 receptor (KISS1R) gene causes normosmic congenital hypogonadotropic hypogonadism.
    Moalla M, Hadj Kacem F, Al-Mutery AF, Mahfood M, Mejdoub-Rekik N, Abid M, Mnif-Feki M, Hadj Kacem H., Free PMC Article

    12/14/2019
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