| Comparison of the effects of zinc oxide and zinc oxide nanoparticles on the expression of hepcidin gene in rat liver. | Comparison of the effects of zinc oxide and zinc oxide nanoparticles on the expression of hepcidin gene in rat liver.
Pourmohammad P, Alipanah-Moghadam R, Nemati A, Malekzadeh V, Mahmoodzadeh Y. | 11/22/2021 |
| Intestinal iron absorption is appropriately modulated to match physiological demand for iron in wild-type and iron-loaded Hamp (hepcidin) knockout rats during acute colitis. | Intestinal iron absorption is appropriately modulated to match physiological demand for iron in wild-type and iron-loaded Hamp (hepcidin) knockout rats during acute colitis.
Flores SRL, Nelson S, Woloshun RR, Wang X, Ha JH, Lee JK, Yu Y, Merlin D, Collins JF., Free PMC Article | 11/13/2021 |
| DNA methylation suppresses liver Hamp expression in response to iron deficiency after bariatric surgery. | DNA methylation suppresses liver Hamp expression in response to iron deficiency after bariatric surgery.
Huang Y, Zhang H, Wang C, Zhou J, Li Y, Hu C. | 02/13/2021 |
| ata thereby indicate that heat stroke can decrease learning ability and memory in rats. The mechanism may be related to changes of iron levels, as well as Fpn1 and hepcidin expression, in the hippocampus. | Dysfunction of Iron Metabolism and Iron-Regulatory Proteins in the Rat Hippocampus After Heat Stroke.
Liu J, Wan M, Zhang Y, Zhang S, Zhang H, Wu S. | 06/27/2020 |
| Studied levels of Interleukin-6 and hepcidin in exhaustive running in hearts of both trained and untrained rats. | Interleukin-6 and hepcidin expression changes in cardiac tissue of long-term trained and untrained rats after exhaustive exercise.
Sarıkaya B, Dursun AD, Taylan Deveden EY, Pınar L. | 01/5/2019 |
| Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-kappaB Activation. | Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-κB Activation.
Wang K, Wu J, Cheng F, Huang X, Zeng F, Zhang Y., Free PMC Article | 07/14/2018 |
| In experimental autoimmune encephalomyelitis, we recently found that chronic iron overload influences the course of disease. In females, iron overload accelerated the onset of disease, while in males it accelerated the progression of disease and increased mortality rate. We hypothesize that those differences arise on molecular level in different expression of stress response proteins hepcidin and metallothioneins. | Hepcidin and metallothioneins as molecular base for sex-dependent differences in clinical course of experimental autoimmune encephalomyelitis in chronic iron overload.
Ćurko-Cofek B, Grubić Kezele T, Barac-Latas V. | 06/16/2018 |
| Activin B induced phosphorylation and activation of Smad1/5/8, the BMP-regulated (BR)-Smads. The stimulation of hepcidin transcription by activin B was mediated by ALK2 and ActRIIA, receptors for the TGF-beta family. | Regulation of hepcidin expression by inflammation-induced activin B.
Kanamori Y, Sugiyama M, Hashimoto O, Murakami M, Matsui T, Funaba M., Free PMC Article | 06/9/2018 |
| A high fat diet not only disturbs normal metabolism, but it also leads to liver inflammation which is obvious by the changes in transaminase activity as well as leptin and hepcidin levels. | Alterations in transaminase activity and serum level of leptin and hepcidin induced by high fat diet in albino rats.
Khawar MB, Sheikh N. | 02/24/2018 |
| Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels | Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels.
Kovac S, Böser P, Cui Y, Ferring-Appel D, Casarrubea D, Huang L, Fung E, Popp A, Mueller BK, Hentze MW., Free PMC Article | 01/27/2018 |
| when a high erythropoietic stimulus occurs, hepcidin synthesis is mainly regulated by transferrin saturation; however, when the erythropoiesis rate reaches a specific threshold, extramedullary hematopoiesis is triggered, and the control of hepcidin synthesis is switched to matriptase-2, thus inhibiting hepcidin synthesis. | Recombinant human erythropoietin-induced erythropoiesis regulates hepcidin expression over iron status in the rat.
Ribeiro S, Garrido P, Fernandes J, Rocha S, Rocha-Pereira P, Costa E, Belo L, Reis F, Santos-Silva A. | 01/13/2018 |
| The data of in vitro and in vivo research evidenced on involvement of Hepc in formation of breast cancer cells malignant phenotype and their resistance to doxorubicin. | Hepcidin as a possible marker in determination of malignancy degree and sensitivity of breast cancer cells to cytostatic drugs.
Yalovenko TM, Todor IM, Lukianova NY, Chekhun VF. | 04/8/2017 |
| downregulation of ferroportin-1 and ceruloplasmin caused by hepcidin enhanced iron-dependent oxidative damage and may be the potential mechanism of subarachnoid hemorrhage . | Role of hepcidin and its downstream proteins in early brain injury after experimental subarachnoid hemorrhage in rats.
Tan G, Liu L, He Z, Sun J, Xing W, Sun X. | 02/4/2017 |
| liver iron overload was an important stimuli for hepcidin synthesis, stronger than the inhibitory effect of high rHuEPO doses; moreover, the findings raised the hypothesis that when high inflammation (triggering hepcidin expression) was associated with increased iron stores in hemodialysis patients, hepcidin expression was also upregulated via BMP6, enhancing hepcidin synthesis, leading, therefore, to worsening of anemia | Liver iron is a major regulator of hepcidin gene expression via BMP/SMAD pathway in a rat model of chronic renal failure under treatment with high rHuEPO doses.
Ribeiro S, Garrido P, Fernandes J, Rocha-Pereira P, Costa E, Belo L, Reis F, Santos-Silva A. | 01/28/2017 |
| Rats were treated with different dose levels of a monoclonal antibody that downregulates Hepcidin; results of this morphometric analysis in the liver showed that iron accumulation is not homogenous between liver lobes and the left lateral lobe was the most responsive lobe in the rat. | Quantification of Hepcidin-related Iron Accumulation in the Rat Liver.
Böser P, Mordashova Y, Maasland M, Trommer I, Lorenz H, Hafner M, Seemann D, Mueller BK, Popp A. | 12/17/2016 |
| Hepcidin may be considered as a potential marker of impaired renal function. | Hepcidin as a Biomarker of Impaired Renal Function in Rat Models for Chronic Allograft Nephropathy.
Xue D, Zhou C, Shi Y, Lu H, He X., Free PMC Article | 11/12/2016 |
| a significant decrease of hepcidin expression is observed during late-pregnancy and early-lactation stages, suggesting the important regulatory role that hepcidin plays in iron metabolism during pregnancy and lactation | Effects of Pregnancy and Lactation on Iron Metabolism in Rats.
Gao G, Liu SY, Wang HJ, Zhang TW, Yu P, Duan XL, Zhao SE, Chang YZ., Free PMC Article | 10/22/2016 |
| Study investigated the expression of hepcidin mRNA and protein in normal rat brain and to interpret the findings in the light of the properties of hepcidin as a peptide hormone with an essential role in systemic iron homeostasis | Expression and cellular localization of hepcidin mRNA and protein in normal rat brain.
Raha-Chowdhury R, Raha AA, Forostyak S, Zhao JW, Stott SR, Bomford A., Free PMC Article | 03/26/2016 |
| liver congestion induces hepcidin production, which may result in anemia and functional iron deficiency in some patients with heart failure. | Liver congestion in heart failure contributes to inappropriately increased serum hepcidin despite anemia.
Ohno Y, Hanawa H, Jiao S, Hayashi Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T. | 11/28/2015 |
| Vitamin A deficiency reduced serum iron and transferrin saturation levels, increased spleen iron concentrations, reduced hepatic Hamp and kidney erythropoietin messenger RNA levels and up-regulated hepatic and spleen heme oxygenase-1 gene expression. | Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis.
da Cunha MS, Siqueira EM, Trindade LS, Arruda SF. | 11/14/2015 |
| Data indicate that a moderate decrease in hepatic hepcidin mRNA content was observed in male rats. | Sex differences in iron status and hepcidin expression in rats.
Kong WN, Niu QM, Ge L, Zhang N, Yan SF, Chen WB, Chang YZ, Zhao SE. | 08/29/2015 |
| inhibition of hepcidin may reduce many pathological changes seen in stress-induced depressive disorders. | The role of hepcidin in chronic mild stress-induced depression.
Farajdokht F, Soleimani M, Mehrpouya S, Barati M, Nahavandi A. | 08/29/2015 |
| ferristatin II synergized with BMP6 and IL-6 to enhance hepcidin expression in vitro, However, this synergy was not due to activation of either Smad or Stat3 signaling | The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitro.
Alkhateeb AA, Buckett PD, Gardeck AM, Kim J, Byrne SL, Fraenkel PG, Wessling-Resnick M., Free PMC Article | 08/22/2015 |
| This leads to a serum iron increase, which seems to stimulate hepcidin expression despite no evidence of inflammation, thus suggesting iron as the key modulator of hepcidin synthesis | Iron as the key modulator of hepcidin expression in erythroid antibody-mediated hypoplasia.
Fernandes JC, Garrido P, Ribeiro S, Rocha-Pereira P, Bronze-da-Rocha E, Belo L, Costa E, Reis F, Santos-Silva A., Free PMC Article | 08/15/2015 |
| Colitis increased local hepcidin-25 expression, which was associated with the IL-6/Stat-3 signaling pathway | Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats.
Gotardo ÉM, Ribeiro Gde A, Clemente TR, Moscato CH, Tomé RB, Rocha T, Pedrazzoli J Jr, Ribeiro ML, Gambero A., Free PMC Article | 04/18/2015 |