| results are in line with some previously performed studies suggesting that MCHR2 is not a major contributor to human obesity and the Prader Willi Syndrome phenotype | DNA sequencing and copy number variation analysis of MCHR2 in a cohort of Prader Willi like (PWL) patients.
Geets E, Aerts E, Verrijken A, Van Hoorenbeeck K, Verhulst S, Van Gaal L, Van Hul W. | 04/20/2019 |
| evidence for the involvement of duplications in MCHR2 in alopecia areata pathogenesis in a Central European cohort | Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2.
Fischer J, Degenhardt F, Hofmann A, Redler S, Basmanav FB, Heilmann-Heimbach S, Hanneken S, Giehl KA, Wolff H, Moebus S, Kruse R, Lutz G, Blaumeiser B, Böhm M, Garcia Bartels N, Blume-Peytavi U, Petukhova L, Christiano AM, Nöthen MM, Betz RC. | 05/12/2018 |
| This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression. | Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.
Delacrétaz A, Preisig M, Vandenberghe F, Saigi Morgui N, Quteineh L, Choong E, Gholam-Rezaee M, Kutalik Z, Magistretti P, Aubry JM, von Gunten A, Castelao E, Vollenweider P, Waeber G, Conus P, Eap CB., Free PMC Article | 06/11/2016 |
| Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2 | Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
Chen X, Mihalic J, Fan P, Liang L, Lindstrom M, Wong S, Ye Q, Fu Y, Jaen J, Chen JL, Dai K, Li L. | 08/4/2012 |
| construction of the CHO cell line and the research of MCHR2 molecular characteristics have established a good experimental basis for the further research about the function of MCHR2 gene | Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics.
Yuan C, Bu Y, Sengupta J, Yang J, Huang X, Cheng L, Zhang Q, Yi F, Liu G, Song F. | 02/22/2010 |
| MCHR2 positively mediates the regulation of melanin-concentrating hormone during preadipocyte differentiation and is involved in energy balance regulation without affecting preadipocyte proliferation. | Melanin-concentrating hormone receptor 2 affects 3T3-L1 preadipocyte differentiation.
Yang J, Yuan C, Wei L, Yi F, Song F. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.
Miller CL, Murakami P, Ruczinski I, Ross RG, Sinkus M, Sullivan B, Leonard S., Free PMC Article | 06/24/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesA systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder.
Abou Jamra R, Schulze TG, Becker T, Brockschmidt FF, Green E, Alblas MA, Wendland JR, Adli M, Grozeva D, Strohmeier J, Georgi A, Craddock N, Propping P, Rietschel M, Nöthen MM, Cichon S, Schumacher J. Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
Ghoussaini M, Vatin V, Lecoeur C, Abkevich V, Younus A, Samson C, Wachter C, Heude B, Tauber M, Tounian P, Hercberg S, Weill J, Levy-Marchal C, Le Stunff C, Bougnères P, Froguel P, Meyre D, Ghoussaini M, Vatin V, Lecoeur C, Abkevich V, Younus A, Samson C, Wachter C, Heude B, Tauber M, Tounian P, Hercberg S, Weill J, Levy-Marchal C, Le Stunff C, Bougnères P, Froguel P, Meyre D. Mutation analysis of the MCHR1 gene in human obesity.
Wermter AK, Reichwald K, Büch T, Geller F, Platzer C, Huse K, Hess C, Remschmidt H, Gudermann T, Preibisch G, Siegfried W, Goldschmidt HP, Li WD, Price RA, Biebermann H, Krude H, Vollmert C, Wichmann HE, Illig T, Sørensen TI, Astrup A, Larsen LH, Pedersen O, Eberlé D, Clément K, Blundell J, Wabitsch M, Schäfer H, Platzer M, Hinney A, Hebebrand J. | 03/13/2008 |
| MCHR2 is not a major contributor to polygenic obesity | Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
Ghoussaini M, Vatin V, Lecoeur C, Abkevich V, Younus A, Samson C, Wachter C, Heude B, Tauber M, Tounian P, Hercberg S, Weill J, Levy-Marchal C, Le Stunff C, Bougnères P, Froguel P, Meyre D, Ghoussaini M, Vatin V, Lecoeur C, Abkevich V, Younus A, Samson C, Wachter C, Heude B, Tauber M, Tounian P, Hercberg S, Weill J, Levy-Marchal C, Le Stunff C, Bougnères P, Froguel P, Meyre D. | 01/21/2010 |
| results of molecular simulations of MCHR2 in the free and hormone-bound forms provide suggestions on the amino acids responsible for the transfer of the structural changes from the agonist binding site to the G-protein coupling domains | Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.
Vitale RM, Pedone C, De Benedetti PG, Fanelli F. | 01/21/2010 |
| MCH1 and MCH2 receptors were investigated and are different from those in SVK14 cells. | SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.
Audinot V, Lahaye C, Suply T, Rovère-Jovène C, Rodriguez M, Nicolas JP, Beauverger P, Cardinaud B, Galizzi JP, Fauchère JL, Nahon JL, Boutin JA. | 01/21/2010 |
| The 10-amino-acid cyclic core of the hMCH neuropeptide with the Arg attached to the N-terminus of the disulfide ring is sufficient for full activation of melanin-concentrating hormone receptor 2. | Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.
Bednarek MA, Feighner SD, Hreniuk DL, Palyha OC, Morin NR, Sadowski SJ, MacNeil DJ, Howard AD, Van der Ploeg LH. | 10/24/2001 |