| Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway. | Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway.
Liu R, Zhou D, Yu B, Zhou Z. | 06/21/2024 |
| LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma. | LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma.
Peng Y, Greenland NY, Lang UE, Stohr BA. | 04/9/2022 |
| beta-Trcp and CK1delta-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma. | β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Lu Y, Li X, Liu H, Xue J, Zeng Z, Dong X, Zhang T, Wu G, Yang K, Xu S., Free PMC Article | 07/31/2021 |
| Study found that LZTS2 was downregulated in nasopharyngeal carcinoma patients and predicted poor prognosis. Functionally, we showed that LZTS2 suppresses tumorigenesis and radioresistance in nasopharyngeal carcinoma in a p85-dependent manner. | LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85.
Xu S, Li Y, Lu Y, Huang J, Ren J, Zhang S, Yin Z, Huang K, Wu G, Yang K. | 03/23/2019 |
| LZTS2 promoter hypermethylation is associated with laryngeal squamous cell carcinoma. | LZTS2 promoter hypermethylation: a potential biomarker for the diagnosis and prognosis of laryngeal squamous cell carcinoma.
Shen Z, Lin L, Cao B, Zhou C, Hao W, Ye D., Free PMC Article | 09/1/2018 |
| LZTS2 could inhibit cell proliferation and cell cycle transition at the G1/S phase and was implicated in the regulation of proteins associated with the canonical Wnt pathway, including GSK3B and beta-catenin through inactivating the Akt pathway. | Leucine zipper tumor suppressor 2 inhibits cell proliferation and regulates Lef/Tcf-dependent transcription through Akt/GSK3β signaling pathway in lung cancer.
Cui QZ, Tang ZP, Zhang XP, Zhao HY, Dong QZ, Xu K, Wang EH., Free PMC Article | 11/16/2013 |
| deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development. | Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development.
Johnson DT, Luong R, Lee SH, Peng Y, Shaltouki A, Lee JT, Lin D, Wang Y, Sun Z., Free PMC Article | 04/20/2013 |
| LZTS2 is a beta-catenin-interacting protein and modulates beta-catenin signaling and localization | LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.
Thyssen G, Li TH, Lehmann L, Zhuo M, Sharma M, Sun Z., Free PMC Article | 12/6/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCentrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 12/2/2009 |
| LAPSER1 C terminal domain inhibits katanin(p80/p60)-mediated microtubule severing in vitro. | LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing.
Sudo H, Maru Y. | 01/21/2010 |
| The reciprocal crosstalk between beta-catenin/Tcf pathway and NF-kappaB signaling in hMSCs is mediated through the regulation of lzts2 expression. | Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells.
Hyun Hwa Cho, Hye Joon Joo, Ji Sun Song, Yong Chan Bae, Jin Sup Jung. | 01/21/2010 |