Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1alpha/VEGF signaling pathway: Bioinformatics analysis and experimental validation. | Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1α/VEGF signaling pathway: Bioinformatics analysis and experimental validation. Li Z, Xie L, Zou L, Xiao S, Tao J., Free PMC Article | 04/24/2024 |
DNA repair/recombination protein 54L promotes the progression of lung adenocarcinoma by activating mTORC1 pathway. | DNA repair/recombination protein 54L promotes the progression of lung adenocarcinoma by activating mTORC1 pathway. Liu C, Ren W, Zhang Z, Guan J. | 01/14/2023 |
Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence. | Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence. Wang Y, Zhou T, Chen H, Wen S, Dao P, Chen M. | 09/17/2022 |
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L. | Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L. Nathansen J, Lukiyanchuk V, Hein L, Stolte MI, Borgmann K, Löck S, Kurth I, Baumann M, Krause M, Linge A, Dubrovska A., Free PMC Article | 12/25/2021 |
Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition. | Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition. Bao X, Wang J, Zhou G, Aszodi A, Schönitzer V, Scherthan H, Atkinson MJ, Rosemann M., Free PMC Article | 10/30/2021 |
Association of MTHFR, MTRR and RAD54L Gene Variations with Meningioma and Correlation with Tumor's Histopathological Characteristics on Turkish Cohort. | Association of MTHFR, MTRR and RAD54L Gene Variations with Meningioma and Correlation with Tumor's Histopathological Characteristics on Turkish Cohort. Avsar T, Mohiyuddin R, Calis S, Yapicier O, Kilic T. | 07/31/2021 |
E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair. | E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair. Mun JY, Baek SW, Park WY, Kim WT, Kim SK, Roh YG, Jeong MS, Yang GE, Lee JH, Chung JW, Choi YH, Chu IS, Leem SH., Free PMC Article | 03/6/2021 |
Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1. | Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1. Machida S, Takaku M, Ikura M, Sun J, Suzuki H, Kobayashi W, Kinomura A, Osakabe A, Tachiwana H, Horikoshi Y, Fukuto A, Matsuda R, Ura K, Tashiro S, Ikura T, Kurumizaka H., Free PMC Article | 04/22/2019 |
Data show that the RAD54 N-terminal domain (NTD) is responsible for initiation of branch migration (BM) through two coupled, but distinct steps; specific binding to Holliday junctions and RAD54 oligomerization. | RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions. Goyal N, Rossi MJ, Mazina OM, Chi Y, Moritz RL, Clurman BE, Mazin AV., Free PMC Article | 03/10/2018 |
TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair | Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes. Tong Y, Merino D, Nimmervoll B, Gupta K, Wang YD, Finkelstein D, Dalton J, Ellison DW, Ma X, Zhang J, Malkin D, Gilbertson RJ., Free PMC Article | 07/25/2015 |
support a model in which RAD54L and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in tumor cells | RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. Mason JM, Dusad K, Wright WD, Grubb J, Budke B, Heyer WD, Connell PP, Weichselbaum RR, Bishop DK., Free PMC Article | 06/27/2015 |
Meta-analysis of gene-disease association. (HuGE Navigator) | Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies. Shen M, Menashe I, Morton LM, Zhang Y, Armstrong B, Wang SS, Lan Q, Hartge P, Purdue MP, Cerhan JR, Grulich A, Cozen W, Yeager M, Holford TR, Vajdic CM, Davis S, Leaderer B, Kricker A, Severson RK, Zahm SH, Chatterjee N, Rothman N, Chanock SJ, Zheng T., Free PMC Article | 12/5/2010 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (2) articlesPolymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q. DNA repair gene polymorphisms and risk of pancreatic cancer. Li D, Suzuki H, Liu B, Morris J, Liu J, Okazaki T, Li Y, Chang P, Abbruzzese JL. | 02/11/2009 |
Rad51 protein stimulates the branch migration activity of Rad54 protein.( | Rad51 protein stimulates the branch migration activity of Rad54 protein. Rossi MJ, Mazin AV., Free PMC Article | 01/21/2010 |
germline mutations in RAD51, RAD51AP1, RAD51L1, RAD51L3, RAD52 and RAD54L are unlikely to be causal of an inherited predisposition to CLL. | Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia. Sellick G, Fielding S, Qureshi M, Catovsky D, International Familial CLL Consortium, Houlston R. | 01/21/2010 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Comprehensive analysis of DNA repair gene variants and risk of meningioma. Bethke L, Murray A, Webb E, Schoemaker M, Muir K, McKinney P, Hepworth S, Dimitropoulou P, Lophatananon A, Feychting M, Lönn S, Ahlbom A, Malmer B, Henriksson R, Auvinen A, Kiuru A, Salminen T, Johansen C, Christensen HC, Kosteljanetz M, Swerdlow A, Houlston R. | 04/3/2008 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (3) articlesGamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert MR, Aldape KD, Xing J, Wu X, Wei Q, Bondy ML. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J. Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. Li D, Liu H, Jiao L, Chang DZ, Beinart G, Wolff RA, Evans DB, Hassan MM, Abbruzzese JL. | 03/13/2008 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. Li D, Frazier M, Evans DB, Hess KR, Crane CH, Jiao L, Abbruzzese JL., Free PMC Article | 03/13/2008 |
Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (7) articlesVariation within DNA repair pathway genes and risk of multiple sclerosis. Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q. Genetic susceptibility to distinct bladder cancer subphenotypes. Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease. Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker. Leone PE, Mendiola M, Alonso J, Paz-y-Miño C, Pestaña A, Leone PE, Mendiola M, Alonso J, Paz-y-Miño C, Pestaña A. | 03/13/2008 |
Rad54 protein causes dissociation of joint molecules by ATP-dependent branch-migration and therefore plays an important role in double strand DNA break repair. | Rad54 dissociates homologous recombination intermediates by branch migration. Bugreev DV, Hanaoka F, Mazin AV. | 01/21/2010 |
analysis of human rad54 protein interactions with branched DNA molecules | Interactions of human rad54 protein with branched DNA molecules. Mazina OM, Rossi MJ, Thomaä NH, Mazin AV. | 01/21/2010 |
Some immortal cells use the alternative lengthening of telomeres (ALT) pathway to maintain their telomeres instead of telomerase. This is the first genetic evidence that Rad54 is dispensable for the ALT pathway. | Rad54 is dispensable for the ALT pathway. Akiyama K, Yusa K, Hashimoto H, Poonepalli A, Hande MP, Kakazu N, Takeda J, Tachibana M, Shinkai Y. | 01/21/2010 |
Shortened telomeres in murine scid cells expressing mutant RAD54L coincide wirth reduction in recombination at telomeres. | Shortened telomeres in murine scid cells expressing mutant hRAD54 coincide with reduction in recombination at telomeres. Al-Wahiby S, Wong HP, Slijepcevic P. | 01/21/2010 |
The RAD54L polymorphism (2290C/T) can be used as a genetic marker inside the consensus deletion region at 1p32 in human meningiomas. | Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker. Leone PE, Mendiola M, Alonso J, Paz-y-Miño C, Pestaña A, Leone PE, Mendiola M, Alonso J, Paz-y-Miño C, Pestaña A., Free PMC Articles: PMC152652, PMC152652 | 01/21/2010 |
RAD54 is recruited by RAD51-ssDNA filament to the chromatin of the intact chromosome and it remodels that chromatin to facilitate accessibility for strand exchange | Homology-driven chromatin remodeling by human RAD54. Zhang Z, Fan HY, Goldman JA, Kingston RE. | 01/21/2010 |