| NR0B2 Is a Key Factor for Gastric Diseases: A GEO Database Analysis Combined with Drug-Target Mendelian Randomization. | NR0B2 Is a Key Factor for Gastric Diseases: A GEO Database Analysis Combined with Drug-Target Mendelian Randomization.
Li Z, Xu L, Huang D, Li C, Haenen GRMM, Zhang M., Free PMC Article | 10/5/2024 |
| SHP-1 alleviates atrial fibrosis in atrial fibrillation by modulating STAT3 activation. | SHP-1 alleviates atrial fibrosis in atrial fibrillation by modulating STAT3 activation.
Zang X, Zhao Z, Chen K, Song W, Ma J, Fu H, Wang X, Zhao Y., Free PMC Article | 09/28/2023 |
| The effectiveness of small heterodimer partner and FGF 19 levels in prediction of perinatal morbidity in intrahepatic cholestasis of pregnancy. | The effectiveness of small heterodimer partner and FGF 19 levels in prediction of perinatal morbidity in intrahepatic cholestasis of pregnancy.
Bayram M, Irak K, Cifci S, Koksal AR, Kazezoglu C, Acar Z, Ozarı HO, Alkim H. | 08/27/2022 |
| The orphan nuclear receptor NR0B2 could be a novel susceptibility locus associated with microsatellite-stable, APC mutation-negative early-onset colorectal carcinomas with metabolic manifestation. | The orphan nuclear receptor NR0B2 could be a novel susceptibility locus associated with microsatellite-stable, APC mutation-negative early-onset colorectal carcinomas with metabolic manifestation.
Lam KK, Sethi R, Tan G, Tomar S, Lo M, Loi C, Tang CL, Tan E, Lai PS, Cheah PY. | 01/15/2022 |
| The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease. | The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease.
Wu J, Nagy LE, Wang L., Free PMC Article | 12/4/2021 |
| Nuclear receptor SHP dampens transcription function and abrogates mitotic chromatin association of PXR and ERalpha via intermolecular interactions. | Nuclear receptor SHP dampens transcription function and abrogates mitotic chromatin association of PXR and ERα via intermolecular interactions.
Kumar S, Vijayan R, Dash AK, Gourinath S, Tyagi RK. | 07/3/2021 |
| Loss of SHP expression is associated with nonalcoholic steatohepatitis. | Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis.
Zou A, Magee N, Deng F, Lehn S, Zhong C, Zhang Y., Free PMC Article | 01/19/2019 |
| results suggest that NR0B2 is a tumor suppressor gene in ccRCC, and that the hypermethylation of promoter region is the main mechanism of its downregulation. | [Suppression of NR0B2 gene in Clear Cell Renal Cell Carcinoma Is Associated with Hypermethylation of Its Promoter].
Kudryavtseva AV, Nyushko KM, Zaretsky AR, Shagin DA, Sadritdinova AF, Fedorova MS, Savvateeva MV, Guvatova ZG, Pudova EA, Alekseev BY, Dmitriev AA, Snezhkina AV. | 12/22/2018 |
| DDX3 regulates MTP gene expression and lipid homeostasis through interplay with HNF4 and SHP. | RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.
Tsai TY, Wang WT, Li HK, Chen WJ, Tsai YH, Chao CH, Wu Lee YH., Free PMC Article | 10/27/2018 |
| The miR-141 was significantly up-regulated in the samples of metastatic tumors compared to localized tumor samples. Tumor samples showed lower SHP mRNA expression levels than BPH samples. | Aberrant expression of miR-141 and nuclear receptor small heterodimer partner in clinical samples of prostate cancer.
Khorasani M, Teimoori-Toolabi L, Farivar TN, Asgari M, Abolhasani M, Shahrokh H, Afgar A, Kalantari E, Peymani A, Mahdian R. | 10/6/2018 |
| The impact of these variants on transactivation of the NR0B2 promoter by NRs known to be regulators of SHP1 expression was assessed in a cell-based reporter gene assay, showing that transactivation by hepatocyte nuclear factor 4alpha and liver receptor homolog-1 was significantly decreased in the presence of the genetic variant NR0B2:c.-594T> | Functional assessment of genetic variants located in the promoter of SHP1 (NR0B2).
Prestin K, Olbert M, Hussner J, Völzke H, Meyer Zu Schwabedissen HE. | 07/14/2018 |
| Data indicate a functional interaction between small heterodimer partner protein SHP1 and hepatitis C virus (HCV) NS5A protein. | Small heterodimer partner 1 directly interacts with NS5A viral protein and has a key role in HCV related liver cell transformation.
Conti B, Porcu C, Viscomi C, Minutolo A, Costantini S, Corazzari M, Iannucci G, Barbaro B, Balsano C., Free PMC Article | 03/10/2018 |
| This study was performed to test the hypothesis that the SHP gene is a target gene of DEC1. Cotransfection demonstrated that DEC1 repressed the SHP promoter and attenuated the transactivation of the classic circadian activator complex of Clock/Bmal1. | Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP).
Marczak MM, Yan B., Free PMC Article | 09/23/2017 |
| The molecular dynamics and structural analysis of the small heterodimer partner in complex with glucocorticoid receptor is described. | Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.
Weikum ER, Okafor CD, D'Agostino EH, Colucci JK, Ortlund EA., Free PMC Article | 06/24/2017 |
| The finding that overexpression of HIF-1alpha increased the activity of the CYP7A1 promoter suggested that hypoxia decreased the expression of CYP7A1 in a HIF-1-independent manner. | Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism.
Moon Y, Park B, Park H., Free PMC Article | 01/28/2017 |
| Results demonstrated a detrimental effect of Bcl2 and H19 associated with cholestatic liver fibrosis and an indispensable role of Shp to maintain normal liver function. | Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function.
Zhang Y, Liu C, Barbier O, Smalling R, Tsuchiya H, Lee S, Delker D, Zou A, Hagedorn CH, Wang L., Free PMC Article | 01/14/2017 |
| These findings show that POD-1/TCF21 regulates SF-1 and LRH-1 by distinct mechanisms, contributing to the understanding of POD-1 involvement and its mechanisms of action in adrenal and liver tumorigenesis. | POD-1/TCF21 Reduces SHP Expression, Affecting LRH-1 Regulation and Cell Cycle Balance in Adrenocortical and Hepatocarcinoma Tumor Cells.
França MM, Ferraz-de-Souza B, Lerario AM, Fragoso MC, Lotfi CF., Free PMC Article | 07/16/2016 |
| Overexpression of SHP and activation of AMPK reverses profibrogenic features of HCV-infected cells by decreasing TGF-beta and fibrotic gene expression. | Small heterodimer partner attenuates profibrogenic features of hepatitis C virus-infected cells.
Jung GS, Jeon JH, Choi YK, Jang SY, Park SY, Kim MK, Shin EC, Jeong WI, Lee IK, Kang YN, Park KG. | 07/16/2016 |
| Data suggest that LRH1/NR5A2 (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 (co-activator; transcription intermediary factor 2) and SHP. | Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.
Musille PM, Kossmann BR, Kohn JA, Ivanov I, Ortlund EA., Free PMC Article | 06/4/2016 |
| At the molecular level, estrogen upregulated hepatic SHP expression through binding to its proximal promoter. In addition, the roles of estrogen were largely blunted in mice with SHP deficiency. | Hepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner.
Wang X, Lu Y, Wang E, Zhang Z, Xiong X, Zhang H, Lu J, Zheng S, Yang J, Xia X, Yang S, Li X. | 04/2/2016 |
| These data are suggestive of a role for SHP in controlling NLRP3 inflammasome activation through a mechanism involving interaction with NLRP3 and maintenance of mitochondrial homeostasis. | Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome.
Yang CS, Kim JJ, Kim TS, Lee PY, Kim SY, Lee HM, Shin DM, Nguyen LT, Lee MS, Jin HS, Kim KK, Lee CH, Kim MH, Park SG, Kim JM, Choi HS, Jo EK., Free PMC Article | 02/6/2016 |
| These results establish SHP as a novel antihypertrophic regulator that acts by interfering with GATA6 signaling. | Small heterodimer partner blocks cardiac hypertrophy by interfering with GATA6 signaling.
Nam YS, Kim Y, Joung H, Kwon DH, Choe N, Min HK, Kim YS, Kim HS, Kim DK, Cho YK, Kim YH, Nam KI, Choi HC, Park DH, Suk K, Lee IK, Ahn Y, Lee CH, Choi HS, Eom GH, Kook H. | 05/23/2015 |
| E2F1 transcription factor activates early growth response (Egr)-1 promoter which is repressed by SHP and EIA-like inhibitor of differentiation (EID)1. | E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 network.
Zhang Y, Xu N, Xu J, Kong B, Copple B, Guo GL, Wang L., Free PMC Article | 11/8/2014 |
| SHP regulates PDCD5-mediated apoptosis in cancer cells | NF-κB p65 recruited SHP regulates PDCD5-mediated apoptosis in cancer cells.
Murshed F, Farhana L, Dawson MI, Fontana JA. | 08/23/2014 |
| Activation of the VDR represses hepatic SHP to increase levels of CYP7A1 and reduce cholesterol. | Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.
Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS. | 05/17/2014 |