| Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway. | Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway.
Tripathi AK, Desai PP, Tyagi A, Lampe JB, Srivastava Y, Donkor M, Jones HP, Dzyuba SV, Crossley E, Williams NS, Vishwanatha JK., Free PMC Article | 04/4/2024 |
| MiR-124-5p Inhibits the Progression of Gastric Cancer by Targeting MIEN1. | MiR-124-5p Inhibits the Progression of Gastric Cancer by Targeting MIEN1.
Liang F, Zhang H, Qiu Y, Xu Q, Jian K, Jiang L, Wang F, Lu X., Free PMC Article | 11/27/2021 |
| data identified that the promotion of gastric cancer (GC) growth and metastasis induced by circRNA_100876 interacted with miR-136 and MIEN1, indicating an emerging announcement for uncovering the potential mechanism of GC progression | CircRNA_100876 sponges miR-136 to promote proliferation and metastasis of gastric cancer by upregulating MIEN1 expression.
Yu X, Xiao W, Song H, Jin Y, Xu J, Liu X. | 06/20/2020 |
| these results suggest the MIEN1 promoter has a short interspersed nuclear Alu element region that is hypermethylated in normal cells leading to repression of the gene; in cancer, the hypomethylation of a part of this repeat, in addition to the binding of USF, results in MIEN1 expression | MIEN1 is tightly regulated by SINE Alu methylation in its promoter.
Rajendiran S, Gibbs LD, Van Treuren T, Klinkebiel DL, Vishwanatha JK., Free PMC Article | 02/24/2018 |
| Data show that migration and invasion enhancer 1 (MIEN1) plays an essential role in maintaining the plasticity of the dynamic membrane-associated actin cytoskeleton, which leads to an increase in cell motility, suggesting targeting MIEN1 might represent a promising means to prevent breast tumor metastasis. | MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics.
Kpetemey M, Chaudhary P, Van Treuren T, Vishwanatha JK., Free PMC Article | 01/20/2018 |
| Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells. | Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells.
Che W, Bao Y, Tang F., Free PMC Article | 10/21/2017 |
| indicate that MIEN1 overexpression may facilitate migration and invasion in breast cancer | Migration and invasion enhancer 1 (MIEN1) is overexpressed in breast cancer and is a potential new therapeutic molecular target.
Zhao HB, Zhang XF, Wang HB, Zhang MZ. | 03/18/2017 |
| In conclusion, this study revealed that miR-26b suppresses NSCLC metastasis by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways, implicating a potential prognostic biomarker and therapeutic target for NSCLC treatment. | MicroRNA-26b suppresses the metastasis of non-small cell lung cancer by targeting MIEN1 via NF-κB/MMP-9/VEGF pathways.
Li D, Wei Y, Wang D, Gao H, Liu K. | 08/13/2016 |
| MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. | MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression.
Kpetemey M, Dasgupta S, Rajendiran S, Das S, Gibbs LD, Shetty P, Gryczynski Z, Vishwanatha JK., Free PMC Article | 03/26/2016 |
| MIEN1 expression not only positively correlates with oral cancer progression but also seems to be a critical molecular determinant in migration and invasion of oral cancer cells. | MIEN1 promotes oral cancer progression and implicates poor overall survival.
Rajendiran S, Kpetemey M, Maji S, Gibbs LD, Dasgupta S, Mantsch R, Hare RJ, Vishwanatha JK., Free PMC Article | 03/12/2016 |
| C35 might serve as a biomarker or therapeutic target for management of colorectal cancer. | C35 is overexpressed in colorectal cancer and is associated tumor invasion and metastasis.
Dong X, Huang Y, Kong L, Li J, Kou J, Yin L, Yang J. | 03/5/2016 |
| While MIEN1 is a direct target of miR-940, miR-940 alters MIEN1 RNA. | MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1.
Rajendiran S, Parwani AV, Hare RJ, Dasgupta S, Roby RK, Vishwanatha JK., Free PMC Article | 07/25/2015 |
| results suggest that DeltaNp73 might cooperate with C35 to promote tumour progression and contribute to cisplatin resistance in ovarian cancer cells. | The interaction between C35 and ΔNp73 promotes chemo-resistance in ovarian cancer cells.
Leung TH, Wong SC, Chan KK, Chan DW, Cheung AN, Ngan HY., Free PMC Article | 11/16/2013 |
| Results suggest that MIEN1 may have an important regulatory role in phosphorylation of AKT with its redox potential. | Solution structure of the oncogenic MIEN1 protein reveals a thioredoxin-like fold with a redox-active motif.
Hsu CH, Shen TL, Chang CF, Chang YY, Huang LY., Free PMC Article | 06/22/2013 |
| prenylation is required for the function of the C17orf37 protein in cancer cells | Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis.
Dasgupta S, Cushman I, Kpetemey M, Casey PJ, Vishwanatha JK., Free PMC Article | 09/17/2011 |
| Inhibition of C35 gene expression by small interfering RNA induces apoptosis of breast cancer cells. | Inhibition of C35 gene expression by small interfering RNA induces apoptosis of breast cancer cells.
Liu QQ, Yin K, Zhu S, Zhang L, Wen PE, Li CL, Zhang DB, Liu M, Yan G. | 02/26/2011 |
| Data strongly suggest C17orf37 overexpression in prostate cancer functionally enhances migration and invasion of tumor cells, and is an important target for cancer therapy. | Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells.
Dasgupta S, Wasson LM, Rauniyar N, Prokai L, Borejdo J, Vishwanatha JK., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCommon genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD. HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer.
Benusiglio PR, Pharoah PD, Smith PL, Lesueur F, Conroy D, Luben RN, Dew G, Jordan C, Dunning A, Easton DF, Ponder BA. | 03/13/2008 |
| Oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML-GSDM locus. | Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon.
Katoh M, Katoh M. | 03/12/2004 |
| MGC14832 gene is located within human chromosome 17q12 amplicon, including PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832 and GRB7 genes. PPP1R1B ~ ERBB2 ~ GRB7 locus is amplified in human gastric cancer and breast cancer. | MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain.
Katoh M, Katoh M. | 12/3/2003 |