| Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting. | Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting.
Kubota Y, Gu X, Terkawi L, Bodo J, Przychodzen BP, Awada H, Williams N, Gurnari C, Kawashima N, Aly M, Durmaz A, Mori M, Ponvilawan B, Kewan T, Bahaj W, Meggendorfer M, Jha BK, Visconte V, Rogers HJ, Haferlach T, Maciejewski JP., Free PMC Article | 03/4/2024 |
| PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer. | PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer.
Gao S, Zhang W, Ma J, Ni X., Free PMC Article | 03/29/2023 |
| PHF6 promotes the progression of endometrial carcinoma by increasing cancer cells growth and decreasing T-cell infiltration. | PHF6 promotes the progression of endometrial carcinoma by increasing cancer cells growth and decreasing T-cell infiltration.
Wang X, Fang A, Peng Y, Yu J, Yu C, Xie J, Zheng Y, Song L, Li P, Li J, Kang X, Lin Y, Li W., Free PMC Article | 03/7/2023 |
| PHF6 mutation is associated with poor outcome in acute myeloid leukaemia. | PHF6 mutation is associated with poor outcome in acute myeloid leukaemia.
Huang K, Wang L, Zheng Y, Yue C, Xu X, Chen H, Huang R, Li Y., Free PMC Article | 02/24/2023 |
| The Role of PHF6 in Hematopoiesis and Hematologic Malignancies. | The Role of PHF6 in Hematopoiesis and Hematologic Malignancies.
Eisa YA, Guo Y, Yang FC. | 01/28/2023 |
| MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression. | MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression.
Gao X, Fan S, Zhang X. | 09/10/2022 |
| Further characterization of Borjeson-Forssman-Lehmann syndrome in females due to de novo variants in PHF6. | Further characterization of Borjeson-Forssman-Lehmann syndrome in females due to de novo variants in PHF6.
Gerber CB, Fliedner A, Bartsch O, Berland S, Dewenter M, Haug M, Hayes I, Marin-Reina P, Mark PR, Martinez-Castellano F, Maystadt I, Karadurmus D, Steindl K, Wiesener A, Zweier M, Sticht H, Zweier C., Free PMC Article | 08/13/2022 |
| Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair. | Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair.
Alvarez S, da Silva Almeida AC, Albero R, Biswas M, Barreto-Galvez A, Gunning TS, Shaikh A, Aparicio T, Wendorff A, Piovan E, Van Vlierberghe P, Gygi S, Gautier J, Madireddy A, A Ferrando A., Free PMC Article | 06/25/2022 |
| LINC00958/miR-3174/PHF6 axis is responsible for triggering proliferation, migration and invasion of endometrial cancer. | LINC00958/miR-3174/PHF6 axis is responsible for triggering proliferation, migration and invasion of endometrial cancer.
Li QY, Shen JQ, Li JH, Dai DF, Saeed M, Li CX. | 04/2/2022 |
| Nonleukemic T/B mixed phenotype acute leukemia with PHF6 and NOTCH1 mutations. | Nonleukemic T/B mixed phenotype acute leukemia with PHF6 and NOTCH1 mutations.
Silva O, Kurzer J. | 12/4/2021 |
| Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3. | Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3.
Huang X, Zhang X, Zong L, Gao Q, Zhang C, Wei R, Guan Y, Huang L, Zhang L, Lyu G, Tao W., Free PMC Article | 11/27/2021 |
| A Novel Missense Variant in PHF6 Gene Causing Borjeson-Forssman-Lehman Syndrome. | A Novel Missense Variant in PHF6 Gene Causing Börjeson-Forssman-Lehman Syndrome.
Bellad A, Bandari AK, Pandey A, Girimaji SC, Muthusamy B. | 06/12/2021 |
| Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation. | Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation.
Cai T, Wu W, Guo L, Xia Y, Jiang X, Zhang L, Peng F, Ming P., Free PMC Article | 05/8/2021 |
| PHF6 promotes non-homologous end joining and G2 checkpoint recovery. | PHF6 promotes non-homologous end joining and G2 checkpoint recovery.
Warmerdam DO, Alonso-de Vega I, Wiegant WW, van den Broek B, Rother MB, Wolthuis RM, Freire R, van Attikum H, Medema RH, Smits VA., Free PMC Article | 05/8/2021 |
| Loss of PHF6 leads to aberrant development of human neuron-like cells. | Loss of PHF6 leads to aberrant development of human neuron-like cells.
Fliedner A, Gregor A, Ferrazzi F, Ekici AB, Sticht H, Zweier C., Free PMC Article | 03/13/2021 |
| Grandparental genotyping enhances exome variant interpretation. | Grandparental genotyping enhances exome variant interpretation.
Daum H, Mor-Shaked H, Ta-Shma A, Shaag A, Silverstein S, Shohat M, Elpeleg O, Meiner V, Harel T. | 02/6/2021 |
| Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis. | Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis.
Miyagi S, Iwama A. | 01/9/2021 |
| Upregulated Plant Homeodomain Finger Protein 6 Promotes Extracellular Matrix Degradation in Intervertebral Disc Degeneration Based on Microarray Analysis. | Upregulated Plant Homeodomain Finger Protein 6 Promotes Extracellular Matrix Degradation in Intervertebral Disc Degeneration Based on Microarray Analysis.
Rui G, Sun N, Hu B, Lin S, Wang Z, Lin Q. | 12/19/2020 |
| The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes. | The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes.
Oh S, Boo K, Kim J, Baek SA, Jeon Y, You J, Lee H, Choi HJ, Park D, Lee JM, Baek SH., Free PMC Article | 10/31/2020 |
| Isothermal titration calorimetry and surface plasmon resonance experiments with PHF6 and full-length Tau (FL-Tau), respectively, indicated that Purpurin interacted with PHF6 predominantly via hydrophobic contacts and displayed a dose-dependent complexation with FL-Tau | Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer's disease-like symptoms in animal model.
Viswanathan GK, Shwartz D, Losev Y, Arad E, Shemesh C, Pichinuk E, Engel H, Raveh A, Jelinek R, Cooper I, Gosselet F, Gazit E, Segal D. | 07/11/2020 |
| PHF6 mutations are early events and drivers of leukemia stem cell activity in the pathogenesis of T-cell acute lymphoblastic leukemia. | Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL.
Wendorff AA, Quinn SA, Rashkovan M, Madubata CJ, Ambesi-Impiombato A, Litzow MR, Tallman MS, Paietta E, Paganin M, Basso G, Gastier-Foster JM, Loh ML, Rabadan R, Van Vlierberghe P, Ferrando AA., Free PMC Article | 05/16/2020 |
| PHF6-mutated MPAL occurred in a younger patient cohort compared with DNMT3A-mutated cases. All 3 MPAL cases with both T- and B-lineage differentiation harbored PHF6 mutations. | PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation.
Xiao W, Bharadwaj M, Levine M, Farnhoud N, Pastore F, Getta BM, Hultquist A, Famulare C, Medina JS, Patel MA, Gao Q, Lewis N, Pichardo J, Baik J, Shaffer B, Giralt S, Rampal R, Devlin S, Cimera R, Zhang Y, E Arcila M, Papaemmanuil E, Levine RL, Roshal M., Free PMC Article | 09/28/2019 |
| PHF6 was significantly elevated in hepatocellular carcinoma (HCC) tissues and positively correlated with TNM stage, differentiation, and lymph node metastasis. Silencing PHF6 significantly inhibited cell proliferation, colony formation, and migration in HCC cells. Furthermore, silencing PHF6 obviously increased E-cadherin and decreased Vimentin expression. | Downregulation of PHF6 Inhibits Cell Proliferation and Migration in Hepatocellular Carcinoma.
Yu Q, Yin L, Jian Y, Li P, Zeng W, Zhou J. | 09/14/2019 |
| EZH2 mutations coexisted with mutations of NOTCH1, IL7R, and PHF6 in the two Adult T-cell Acute Lymphoblastic Leukemia patients, and they responded poorly to chemotherapy and experienced difficult clinical histories and inferior outcomes | Coexistence of EZH2, NOTCH1, IL7R, and PHF6 Mutations in Adult T-cell Acute Lymphoblastic Leukemia.
Zhou X, Gu Y, Han Q, Soliman M, Song C, Ge Z., Free PMC Article | 10/6/2018 |
| PHF6 mutations occur at a low frequency in pediatric acute myeloid leukemia in both female and male patients | PHF6 mutations in paediatric acute myeloid leukaemia.
de Rooij JD, van den Heuvel-Eibrink MM, van de Rijdt NK, Verboon LJ, de Haas V, Trka J, Baruchel A, Reinhardt D, Pieters R, Fornerod M, Zwaan CM. | 03/31/2018 |