| LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis. | LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis.
Zhao L, Pei R, Ding Y, Su Z, Li D, Zhu S, Xu L, Zhao H, Zhou W. | 02/8/2024 |
| The possibilities of LOXL4 as a prognostic marker for carcinomas. | The possibilities of LOXL4 as a prognostic marker for carcinomas.
Wang J, Chen C, Huang J, Xie Z, Chen X, Zheng Z, Li E, Zou H. | 12/5/2023 |
| LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung. | LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung.
Ma HY, Li Q, Wong WR, N'Diaye EN, Caplazi P, Bender H, Huang Z, Arlantico A, Jeet S, Wong A, Emson C, Brightbill H, Tam L, Newman R, Roose-Girma M, Sandoval W, Ding N., Free PMC Article | 05/30/2023 |
| Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer. | Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer.
Altuntaş OM, Süslü N, Güler Tezel YG, Tatlı Doğan H, Yılmaz T., Free PMC Article | 11/5/2022 |
| LAMA2 and LOXL4 are candidate FSGS genes. | LAMA2 and LOXL4 are candidate FSGS genes.
Vijayan P, Hack S, Yao T, Qureshi MA, Paterson AD, John R, Davenport B, Lennon R, Pei Y, Barua M., Free PMC Article | 02/26/2022 |
| Lysyl Oxidase-Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis. | Lysyl Oxidase-Like 4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis.
Tan HY, Wang N, Zhang C, Chan YT, Yuen MF, Feng Y., Free PMC Article | 01/1/2022 |
| LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice. | LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.
Li H, Guo J, Jia Y, Kong W, Li W., Free PMC Article | 08/14/2021 |
| Neutrophils expressing lysyl oxidase-like 4 protein are present in colorectal cancer liver metastases resistant to anti-angiogenic therapy. | Neutrophils expressing lysyl oxidase-like 4 protein are present in colorectal cancer liver metastases resistant to anti-angiogenic therapy.
Palmieri V, Lazaris A, Mayer TZ, Petrillo SK, Alamri H, Rada M, Jarrouj G, Park WY, Gao ZH, McDonald PP, Metrakos P. | 09/26/2020 |
| Derepression of LOXL4 inhibits liver cancer growth by reactivating compromised p53. | Derepression of LOXL4 inhibits liver cancer growth by reactivating compromised p53.
Shao J, Lu J, Zhu W, Yu H, Jing X, Wang YL, Wang X, Wang XJ., Free PMC Article | 09/12/2020 |
| we confirmed that LOXL4 could serve as a downstream target of miR-210 and miR-210 promoted lung cancer progression via targeting LOXL4. In A549 and H1650 cells, knockdown of LOXL4 dramatically repressed lung cancer cell proliferation, migration, and invasion. | miR-210 promotes lung adenocarcinoma proliferation, migration, and invasion by targeting lysyl oxidase-like 4.
Xie S, Liu G, Huang J, Hu HB, Jiang W. | 05/30/2020 |
| This study revealed miR-135a-5p might be indicated as a perspective for lung cancer via targeting LOXL4. | Downregulation of lysyl oxidase-like 4 LOXL4 by miR-135a-5p promotes lung cancer progression in vitro and in vivo.
Zhang Y, Jiang WL, Yang JY, Huang J, Kang G, Hu HB, Xie S. | 05/30/2020 |
| High LOXL4 expression is associated with esophageal squamous cell carcinoma. | Clinical significance of LOXL4 expression and features of LOXL4-associated protein-protein interaction network in esophageal squamous cell carcinoma.
Xie W, Huang P, Wu B, Chen S, Huang Z, Wang J, Sun H, Wu J, Xie L, Cheng Y, Xie W, Xu L, Chen LQ, Li E, Zou H. | 08/17/2019 |
| The data demonstrate a novel function of LOXL4 in tumor metastasis mediated by exosomes through regulation of the FAK/Src pathway and angiogenesis in hepatocellular carcinoma. | Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis.
Li R, Wang Y, Zhang X, Feng M, Ma J, Li J, Yang X, Fang F, Xia Q, Zhang Z, Shang M, Jiang S., Free PMC Article | 06/15/2019 |
| trans-suppression of host CDH3 and LOXL4 genes in cultured human intestinal epithelial cells following C. parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA | Trans-suppression of host CDH3 and LOXL4 genes during Cryptosporidium parvum infection involves nuclear delivery of parasite Cdg7_FLc_1000 RNA.
Ming Z, Gong AY, Wang Y, Zhang XT, Li M, Li Y, Pang J, Dong S, Strauss-Soukup JK, Chen XM., Free PMC Article | 05/4/2019 |
| LOXL1, LOXL3, and LOXL4 expressions are associated with distant metastasis of gastric cancer. | Significance of the Lysyl Oxidase Members Lysyl Oxidase Like 1, 3, and 4 in Gastric Cancer.
Kasashima H, Yashiro M, Okuno T, Miki Y, Kitayama K, Masuda G, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Hirakawa K, Ohira M. | 03/23/2019 |
| Our study suggests lack of association between DNA polymorphisms rs2236479 of COL18A1 and rs2862296 of LOXL-4 with advanced POP [pelvic organ prolapse] in this population [Brazil]. | Collagen XVIII and LOXL-4 polymorphisms in women with and without advanced pelvic organ prolapse.
Dos Santos RGM, Pepicelli FCA, Batista NC, de Carvalho CV, Bortolini MAT, Castro RA. | 01/19/2019 |
| study describes for the first time a direct link between a retinoic-induced gene and protein, LOXL4, and its general clinical pro-healing properties in ECM dynamics | Lysyl oxidase-like 4 involvement in retinoic acid epithelial wound healing.
Comptour A, Rouzaire M, Belville C, Bonnin N, Daniel E, Chiambaretta F, Blanchon L, Sapin V., Free PMC Article | 06/16/2018 |
| Although expression of LOXL4 is not statistically associated with neck metastases, we showed that LOXL4 expression significantly increased in laryngeal cancer. | Differential expression of LOXL4 in normal and tumour tissue samples of laryngeal squamous cell carcinoma.
Yilmaz M, Suer I, Karatas OF, Cansiz H, Ozen M. | 10/14/2017 |
| In hepatocellular carcinoma, low LOXL4 expression was associated with lower overall survival rates and higher cumulative recurrence rates. | LOXL4 is downregulated in hepatocellular carcinoma with a favorable prognosis.
Tian M, Liu W, Jin L, Jiang X, Yang L, Ding Z, Shen Y, Peng Y, Gao D, Li L, Zhou J, Qiu S, Dai Z, Fan J, Shi Y., Free PMC Article | 04/9/2016 |
| These results provide a set of the essential genes in this newly identified miR-193a-3p/LOXL4/Oxidative Stress axis. | miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the oxidative stress pathway.
Deng H, Lv L, Li Y, Zhang C, Meng F, Pu Y, Xiao J, Qian L, Zhao W, Liu Q, Zhang D, Wang Y, Zhang H, He Y, Zhu J., Free PMC Article | 07/4/2015 |
| High Lysyl oxidase-like 4 promotes proliferation and metastasis of gastric cancer via FAK/Src pathway. | Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway.
Li RK, Zhao WY, Fang F, Zhuang C, Zhang XX, Yang XM, Jiang SH, Kong FZ, Tu L, Zhang WM, Yang SL, Cao H, Zhang ZG. | 03/21/2015 |
| data suggest that abnormal expression of LOXL4 of KCOT may enhance angiogenesis in KCOT, which may help to promote the locally aggressive biological behavior of KCOT. | Identification of the involvement of LOXL4 in generation of keratocystic odontogenic tumors by RNA-Seq analysis.
Jiang WP, Sima ZH, Wang HC, Zhang JY, Sun LS, Chen F, Li TJ., Free PMC Article | 07/12/2014 |
| TGF-beta1 induced injured MCL to express more LOXs than injured ACL (up to 1.85-fold in LOX, 2.21-fold in LOXL-1, 1.71-fold in LOXL-2, 2.52-fold in LOXL-3 and 3.32-fold in LOXL-4). | TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury.
Xie J, Wang C, Huang DY, Zhang Y, Xu J, Kolesnikov SS, Sung KL, Zhao H. | 08/31/2013 |
| Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer. | Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer.
Sebban S, Golan-Gerstl R, Karni R, Vaksman O, Davidson B, Reich R. | 03/9/2013 |
| The human lysyl oxidase-like 4 gene does not confer increased genotypic risk for adolescent idiopathic scoliosis. | Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype.
McGregor TL, Gurnett CA, Dobbs MB, Wise CA, Morcuende JA, Morgan TM, Menon R, Muglia LJ., Free PMC Article | 10/15/2011 |