| TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells. | TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.
Gao Y, Hou J, Fei X, Ren L, Lu R, Liu P, Liu S, Zhu C, Wang X, Pan Y. | 06/21/2024 |
| Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer. | Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer.
Ji C, Zhao J, Chen H, Wang Z, Cai T, Tian C, Wang C, Liu D, Ye B, Fu M, Sun J, Li H, Wang X, Sun Y. | 11/1/2023 |
| TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway. | TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
He Y, Zhang B, Han D, Du Y, Zhang X, Wang H, Yue Z, Shang P. | 07/27/2023 |
| TAGLN2 promotes papillary thyroid carcinoma invasion via the Rap1/PI3K/AKT axis. | TAGLN2 promotes papillary thyroid carcinoma invasion via the Rap1/PI3K/AKT axis.
Wang L, Tan H, Huang Y, Guo M, Dong Y, Liu C, Zhao H, Liu Z. | 12/24/2022 |
| Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients. | Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients.
Szelenberger R, Jóźwiak P, Kacprzak M, Bijak M, Zielińska M, Olender A, Saluk-Bijak J., Free PMC Article | 06/18/2022 |
| Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis. | Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis.
Wang Y, Chen X, Li J, Xia C. | 05/21/2022 |
| Mechanisms of Transgelin-2 in Tumorigenesis. | Mechanisms of Transgelin-2 in Tumorigenesis.
Zeng C, Zhang H. | 03/12/2022 |
| Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration. | Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.
Ding R, Li G, Yao Y, Zhang L, Zhang X, Li J, Shen T, Gao Y, Wu T, Kong S, Huang M, Li Y. | 03/5/2022 |
| Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment? | Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
Woziwodzka K, Małyszko J, Koc-Żórawska E, Żórawski M, Dumnicka P, Jurczyszyn A, Batko K, Mazur P, Banaszkiewicz M, Krzanowski M, Gołasa P, Małyszko JA, Drożdż R, Krzanowska K., Free PMC Article | 02/12/2022 |
| Transgelin-2 and phosphoregulation of the LIC2 subunit of dynein govern mitotic spindle orientation. | Transgelin-2 and phosphoregulation of the LIC2 subunit of dynein govern mitotic spindle orientation.
Sharma A, Dagar S, Mylavarapu SVS. | 09/4/2021 |
| Transgelin-2 contributes to proliferation and progression of hepatocellular carcinoma via regulating Annexin A2. | Transgelin-2 contributes to proliferation and progression of hepatocellular carcinoma via regulating Annexin A2.
Shi J, Ren M, She X, Zhang Z, Zhao Y, Han Y, Lu D, Lyu L. | 09/12/2020 |
| REVIEW: Biochemical and Clinical Implications in Cancer and Asthma | Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.
Yin LM, Ulloa L, Yang YQ., Free PMC Article | 08/1/2020 |
| The present study proposed TAGLN2 to function as a tumor suppressor and that loss of TAGLN2 may promote the metastasis of breast cancer by activating the ROS/NFkappaB signaling pathway. | Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway.
Yang L, Hong Q, Xu SG, Kuang XY, Di GH, Liu GY, Wu J, Shao ZM, Yu SJ., Free PMC Article | 03/7/2020 |
| Transgelin-2 was highly overexpressed in breast cancer and relevant to progression. High transgelin-2 expression might predict poor outcome in patients with ER-negative tumors. | Transgelin-2 expression in breast cancer and its relationships with clinicopathological features and patient outcome.
Hao R, Liu Y, Du Q, Liu L, Chen S, You H, Dong Y. | 02/29/2020 |
| dual functional nature of TAGLN2-G-actin polymerization and Arp2/3 complex inhibition-may account for the mechanisms of filopodia development at the edge of Arp2/3-rich lamellipodia in various cell types | TAGLN2 polymerizes G-actin in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions.
Kim HR, Kwon MS, Lee S, Mun Y, Lee KS, Kim CH, Na BR, Kim BNR, Piragyte I, Lee HS, Jun Y, Jin MS, Hyun YM, Jung HS, Mun JY, Jun CD., Free PMC Article | 10/5/2019 |
| TAGLN 2 overexpression in HeLa cells could inhibit cell viability, migration and invasion, and it was suggested that this may occur via upregulation of the expression levels of E cadherin and inhibitor of nuclear factor kappalightchainenhancer of activated B cells (NFkappaB) (IkappaB), and downregulation of C XC chemokine receptor type 4, matrix metalloproteinase (MMP)2, MMP9, p50 and transcription factor p65. | Transgelin 2 overexpression inhibits cervical cancer cell invasion and migration.
Zhou Q, Jiang X, Yan W, Dou X. | 09/14/2019 |
| Authors found transgelin-2 expression was induced by KRAS mutation. In the case of KRAS mutation, ERK2 interacted with 29-31 amino acids of transgelin-2 and subsequently phosphorylated the S145 residue of transgelin-2. | Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer.
Sun Y, Peng W, He W, Luo M, Chang G, Shen J, Zhao X, Hu Y., Free PMC Article | 03/30/2019 |
| Study provides important evidence that hypoxia-inducible TAGLN2 is involved in the selection of cancer cells with enhanced EMT properties to overcome the detrimental environment of cancer cells as gamma radiation. | Hypoxia-inducible transgelin 2 selects epithelial-to-mesenchymal transition and γ-radiation-resistant subtypes by focal adhesion kinase-associated insulin-like growth factor 1 receptor activation in non-small-cell lung cancer cells.
Kim IG, Lee JH, Kim SY, Hwang HM, Kim TR, Cho EW., Free PMC Article | 11/24/2018 |
| Results show that Increased expression of TAGLN2 is associated with increasing tumor grade in glioma and poor patient survival. Knockdown experiments highlighted the function of TAGLN2 in promoting glioma cell invasion, the EMT phenotype, and tumor growth. | TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas.
Han MZ, Xu R, Xu YY, Zhang X, Ni SL, Huang B, Chen AJ, Wei YZ, Wang S, Li WJ, Zhang Q, Li G, Li XG, Wang J., Free PMC Article | 07/21/2018 |
| Our data support a novel mechanism in diabetes-associated PDAC by which transgelin-2 mediates proliferation of PDAC cells upon insulin stimulation. | Role of transgelin-2 in diabetes-associated pancreatic ductal adenocarcinoma.
Sun Y, He W, Luo M, Zhou Y, Chang G, Ren W, Wu K, Li X, Shen J, Zhao X, Hu Y., Free PMC Article | 04/28/2018 |
| Results suggest that TAGLN2 might regulate activation and migration of B-cells, in particular, the entry of activated B-cells into the follicle. | Transgelin-2 is upregulated on activated B-cells and expressed in hyperplastic follicles in lupus erythematosus patients.
Kiso K, Yoshifuji H, Oku T, Hikida M, Kitagori K, Hirayama Y, Nakajima T, Haga H, Tsuruyama T, Miyagawa-Hayashino A., Free PMC Article | 10/21/2017 |
| we reviewed the basic characteristics and function of Transgelin-2 and its biological role in various types of diseases in order to provide the theoretical basis for further research and new perspectives on cancer development. | Transgelin-2: A potential oncogenic factor.
Meng T, Liu L, Hao R, Chen S, Dong Y. | 07/15/2017 |
| Our data demonstrated that TAGLN2 might be an HBx induced positive host factor involved in HBV transcription and replication and HBx related liver fibrosis and tumorigenesis | TAGLN2, a novel regulator involved in Hepatitis B virus transcription and replication.
Yu Y, He Z, Cao Y, Tang H, Huang F. | 05/20/2017 |
| Transgelin-2 plays functional roles in the progression of cervical squamous cell carcinoma. Suppression of Transgelin-2 may be a new strategy for the treatment of cervical squamous cell carcinoma. | Functional significance of transgelin-2 in uterine cervical squamous cell carcinoma.
Yakabe K, Murakami A, Kajimura T, Nishimoto Y, Sueoka K, Sato S, Nawata S, Sugino N. | 04/1/2017 |
| It is a target gene of miR-1. | The tumor-suppressive function of miR-1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma.
Du YY, Zhao LM, Chen L, Sang MX, Li J, Ma M, Liu JF. | 11/19/2016 |