| CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway. | CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway.
Sun J, Shi M, Song Z, Hua F, Yan X, Zhang M, Duan H, Liu J. | 08/5/2024 |
| CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages. | CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages.
Jiang J, Wang M, Shen W, Wu J, Ma Q, Wang Z, Chen Z, Bian T, Ji N, Huang M, Zhang M. | 01/29/2024 |
| Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling. | Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling.
Yang X, Xu H, Yang X, Wang H, Zou L, Yang Q, Qi X, Li L, Duan H, Yan X, Fu NY, Tan J, Hou Z, Jiao B., Free PMC Article | 01/5/2024 |
| CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis. | CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis.
Wang Z, Liu W, Hu H, Jiang J, Yang C, Zhang X, Yuan Q, Yang X, Huang M, Bao Y, Ji N, Zhang M. | 09/18/2023 |
| Galphai1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis. | Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
Li Y, Chai JL, Shi X, Feng Y, Li JJ, Zhou LN, Cao C, Li KR., Free PMC Article | 05/12/2023 |
| Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM. | Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
Wang W, Tang X, Duan C, Tian S, Han C, Qian W, Jiang X, Hou X, Lin R., Free PMC Article | 02/11/2023 |
| CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis. | CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis.
Heim X, Bermudez J, Joshkon A, Kaspi E, Bachelier R, Nollet M, Vélier M, Dou L, Brodovitch A, Foucault-Bertaud A, Leroyer AS, Benyamine A, Daumas A, Granel B, Sabatier F, Dignat-George F, Blot-Chabaud M, Bardin N. | 11/26/2022 |
| Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/beta-catenin pathway. | Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.
Zhang ZY, Zhai C, Yang XY, Li HB, Wu LL, Li L., Free PMC Article | 09/3/2022 |
| The CD146-HIF-1alpha axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia. | The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia.
Jin R, Gao Q, Yin C, Zou M, Lu K, Liu W, Zhu Y, Zhang M, Cheng R., Free PMC Article | 07/30/2022 |
| Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy. | Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.
Lin J, Cui K, Xu Y, Tang X, Shi Y, Lu X, Yang B, He Q, Yu S, Liang X. | 05/14/2022 |
| Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria. | Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.
Duan H, Zhao S, Xiang J, Ju C, Chen X, Gramaglia I, Yan X., Free PMC Article | 04/2/2022 |
| CD146 mediates the anti-apoptotic role of Netrin-1 in endothelial progenitor cells under hypoxic conditions. | CD146 mediates the anti-apoptotic role of Netrin-1 in endothelial progenitor cells under hypoxic conditions.
Jiang RC, Zheng XY, Yang SL, Shi HJ, Xi JH, Zou YJ, Dou HQ, Wang YJ, Qin Y, Zhang XL, Xiao Q., Free PMC Article | 02/26/2022 |
| CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice. | CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice.
Duan H, Jing L, Jiang X, Ma Y, Wang D, Xiang J, Chen X, Wu Z, Yan H, Jia J, Liu Z, Feng J, Zhu M, Yan X., Free PMC Article | 12/11/2021 |
| Temporo-spatial distribution of stem cell markers CD146 and p75NTR during odontogenesis in mice. | Temporo-spatial distribution of stem cell markers CD146 and p75NTR during odontogenesis in mice.
Queiroz A, Pelissari C, Arana-Chavez VE, Trierveiler M., Free PMC Article | 10/2/2021 |
| Wnt5a promotes renal tubular inflammation in diabetic nephropathy by binding to CD146 through noncanonical Wnt signaling. | Wnt5a promotes renal tubular inflammation in diabetic nephropathy by binding to CD146 through noncanonical Wnt signaling.
Li X, Wen J, Dong Y, Zhang Q, Guan J, Liu F, Zhou T, Li Z, Fan Y, Wang N., Free PMC Article | 10/2/2021 |
| MCAM/CD146 Signaling via PLCgamma1 Leads to Activation of beta1-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration. | MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β(1)-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration.
Zondler L, Herich S, Kotte P, Körner K, Schneider-Hohendorf T, Wiendl H, Schwab N, Zarbock A., Free PMC Article | 06/19/2021 |
| Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis. | Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis.
Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, Qian Y, Wu C, Hu F, Huang M, Zhang M., Free PMC Article | 04/24/2021 |
| data indicate that CD146 deficiency is associated with the upregulation of RANTES production and increased inflammation of atheroma, which could influence the atherosclerotic plaque fate. Thus, these data identify CD146 agonists as potential new therapeutic candidates for atherosclerosis treatment. | CD146 deficiency promotes plaque formation in a mouse model of atherosclerosis by enhancing RANTES secretion and leukocyte recruitment.
Blin MG, Bachelier R, Fallague K, Moussouni K, Aurrand-Lions M, Fernandez S, Guillet B, Robert S, Foucault-Bertaud A, Bardin N, Blot-Chabaud M, Dignat-George F, Leroyer AS. | 06/20/2020 |
| Study demonstrated that a cross-regulation between CD146 and HIF-1alpha in pulmonary artery smooth muscle cells triggers pulmonary vascular remodeling. CD146 promotes HIF-1alpha transcriptional program through NF-kappaB and HIF-1alpha upregulates CD146 through direct binding to its promoter region. These findings uncover previously uncharacterized hypoxic reprogramming during vascular remodeling. | CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension.
Luo Y, Teng X, Zhang L, Chen J, Liu Z, Chen X, Zhao S, Yang S, Feng J, Yan X., Free PMC Article | 12/14/2019 |
| Study provide explicit evidence that CD146, with elevated expression and activity in a variety of cancers, is a key factor involved in the cadherin switch. CD146 overexpression significantly promotes epithelial-mesenchymal transition (EMT) in both mouse embryonic fibroblasts (MEFs) and ovarian cancer cells. Furthermore, CD146-deficient MEFs exhibited decreased motility as a result of reversion in this cadherin switch. | CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition.
Ma Y, Zhang H, Xiong C, Liu Z, Xu Q, Feng J, Zhang J, Wang Z, Yan X. | 08/10/2019 |
| findings suggest that MCAM is a gene upregulated and involved in maintaining PPARgamma induction in the late but not in the early stages of 3T3-L1 fibroblasts adipogenesis. | MCAM knockdown impairs PPARγ expression and 3T3-L1 fibroblasts differentiation to adipocytes.
Gabrielli M, Romero DG, Martini CN, Raiger Iustman LJ, Vila MDC., Free PMC Article | 11/3/2018 |
| The dynamic expression of CD146 controls the behavior of ECs and pericyte. | CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development.
Chen J, Luo Y, Hui H, Cai T, Huang H, Yang F, Feng J, Zhang J, Yan X., Free PMC Article | 05/26/2018 |
| In summary, we have shown that MUC18/Muc18 may serve as a regulator of airway inflammation and mucus overproduction, two important features of type 2-high asthma. Our data suggest that MUC18/Muc18 or its downstream signaling mediators may be targets for potential therapeutic agents. | MUC18 regulates IL-13-mediated airway inflammatory response.
Stevenson C, Jiang D, Schaefer N, Ito Y, Berman R, Sanchez A, Chu HW., Free PMC Article | 04/21/2018 |
| These findings identify CD146 as a novel retention signal that traps macrophages within the artery wall, and a promising therapeutic target in atherosclerosis treatment. | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis.
Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang F, Feng J, Yang D, Qin Z, Yan X., Free PMC Article | 12/16/2017 |
| Activation of the proteolytic processing of short isoform CD146, in particular by soluble CD146, constitutes a promising pathway to improve endothelial progenitors' regenerative properties for the treatment of cardiovascular diseases. | Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform.
Stalin J, Harhouri K, Hubert L, Garrigue P, Nollet M, Essaadi A, Muller A, Foucault-Bertaud A, Bachelier R, Sabatier F, Pisano P, Peiretti F, Leroyer AS, Guillet B, Bardin N, Dignat-George F, Blot-Chabaud M. | 10/21/2017 |