| Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5. | Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.
Li C, Yoon B, Stefani G, Slack FJ., Free PMC Article | 02/5/2024 |
| Human IL-17A protein production is controlled through a PIP5K1alpha-dependent translational checkpoint. | Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint.
Revu SK, Yang W, Rajasundaram D, Brady A, Majumder S, Gaffen SL, Hawse W, Xia Z, McGeachy MJ., Free PMC Article | 11/1/2023 |
| FcgammaRIIIa receptor interacts with androgen receptor and PIP5K1alpha to promote growth and metastasis of prostate cancer. | FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer.
Larsson PF, Karlsson R, Sarwar M, Miftakhova R, Wang T, Syed Khaja AS, Semenas J, Chen S, Hedblom A, Ali A, Ekström-Holka K, Simoulis A, Kumar A, Wingren AG, Robinson B, Nyunt Wai S, Mongan NP, Heery DM, Öhlund D, Grundström T, Ødum N, Persson JL., Free PMC Article | 07/9/2022 |
| Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis. | Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis.
Feng N, Guo Z, Wu X, Tian Y, Li Y, Geng Y, Yu Y., Free PMC Article | 02/12/2022 |
| CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis. | CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.
Peng JM, Lin SH, Yu MC, Hsieh SY., Free PMC Article | 09/11/2021 |
| Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. | Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.
Parkhitko AA, Singh A, Hsieh S, Hu Y, Binari R, Lord CJ, Hannenhalli S, Ryan CJ, Perrimon N., Free PMC Article | 06/26/2021 |
| Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein. | Phosphatidylinositol-4-phosphate 5-kinase type 1α attenuates Aβ production by promoting non-amyloidogenic processing of amyloid precursor protein.
Wu PF, Bhore N, Lee YL, Chou JY, Chen YW, Wu PY, Hsu WM, Lee H, Huang YS, Lu PJ, Liao YF. | 03/13/2021 |
| Type I Phosphatidylinositol-4-Phosphate 5-Kinases alpha and gamma Play a Key Role in Targeting HIV-1 Pr55(Gag) to the Plasma Membrane. | Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55(Gag) to the Plasma Membrane.
Gonzales B, de Rocquigny H, Beziau A, Durand S, Burlaud-Gaillard J, Lefebvre A, Krull S, Emond P, Brand D, Piver E., Free PMC Article | 11/21/2020 |
| The results suggest that PIP5KA is a novel degradative substrate of NEDD4 and that the PIP5KA-dependent phosphatidylinositol 4,5-diphosphate pool contributing to breast cancer cell proliferation through PI3K/Akt activation is negatively controlled by NEDD4. | NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase α and its implication in breast cancer cell proliferation.
Tran MH, Seo E, Min S, Nguyen QT, Choi J, Lee UJ, Hong SS, Kang H, Mansukhani A, Jou I, Lee SY., Free PMC Article | 11/2/2019 |
| PIP5K1alpha was associated with poor patient outcome in triple-negative BC. It increased expression of pSer-473 AKT and invasiveness of triple-negative MDA-MB-231 cells. Inhibition reduced expression of pSer-473 AKT and its downstream effectors in xenograft tumors. In ER(+) cancer cells, PIP5K1alpha acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of targe... | The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor.
Sarwar M, Syed Khaja AS, Aleskandarany M, Karlsson R, Althobiti M, Ødum N, Mongan NP, Dizeyi N, Johnson H, Green AR, Ellis IO, Rakha EA, Persson JL., Free PMC Article | 04/27/2019 |
| KRAS-specific interactor that mediates oncogenic KRAS signaling and proliferation | Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
Adhikari H, Counter CM., Free PMC Article | 12/22/2018 |
| Blockade of IQGAP1 interaction with PIPKIalpha or PI(3)K inhibited PtdIns(3,4,5)P3 generation and signalling, and selectively diminished cancer cell survival. | Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases.
Choi S, Hedman AC, Sayedyahossein S, Thapa N, Sacks DB, Anderson RA., Free PMC Article | 06/3/2017 |
| These results indicate that PP1 is recruited to the extracellular calcium-dependent E-cadherin-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC-g1 activation leading to keratinocyte differentiation. | Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation.
Shrestha C, Tang Y, Fan H, Li L, Zeng Q, Pennypacker SD, Bikle DD, Xie Z., Free PMC Article | 02/4/2017 |
| PIP5K1A modulates ribosomal RNA gene silencing through its interaction with histone H3 lysine 9 trimethylation and heterochromatin protein HP1-alpha. | Phosphatidylinositol-4-phosphate 5-Kinase 1α Modulates Ribosomal RNA Gene Silencing through Its Interaction with Histone H3 Lysine 9 Trimethylation and Heterochromatin Protein HP1-α.
Chakrabarti R, Sanyal S, Ghosh A, Bhar K, Das C, Siddhanta A., Free PMC Article | 11/21/2015 |
| PIP5K1A is modified by polySUMO-2 only during apoptosis. | Nuclear pool of phosphatidylinositol 4 phosphate 5 kinase 1α is modified by polySUMO-2 during apoptosis.
Chakrabarti R, Bhowmick D, Bhargava V, Bhar K, Siddhanta A. | 11/30/2013 |
| CD28 regulates phosphatidylinositol 4,5-biphosphate turnover by recruiting and activating phosphatidylinositol 4-phosphate 5-kinases alpha in human primary CD4(+) T lymphocytes. | Phosphatidylinositol 4-phosphate 5-kinase α activation critically contributes to CD28-dependent signaling responses.
Muscolini M, Camperio C, Capuano C, Caristi S, Piccolella E, Galandrini R, Tuosto L. | 07/6/2013 |
| Results define the role of PIPKI-alpha in cell migration and describes a new mechanism for the spatial regulation of Rac1 activity that is critical for cell migration. | Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation.
Chao WT, Daquinag AC, Ashcroft F, Kunz J., Free PMC Article | 08/30/2010 |
| Localized production of Phosphatidylinositol 4,5-bisphosphate by PIP5K1A is required for invadopodia formation by breast cancer cells. | Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells.
Yamaguchi H, Yoshida S, Muroi E, Kawamura M, Kouchi Z, Nakamura Y, Sakai R, Fukami K., Free PMC Article | 08/16/2010 |
| Extracellular calcium (Cao) stimulated PIP5K1alpha recruitment to the E-cadherin-catenin complex in the plasma membrane. | Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation.
Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD., Free PMC Article | 01/21/2010 |
| The data suggest that activation of FcgammaRIIA leads to membrane rafts coalescing into signaling platforms containing PIP5-kinase Ialpha and PI(4,5)P(2). | Contribution of PIP-5 kinase Ialpha to raft-based FcgammaRIIA signaling.
Szymańska E, Korzeniowski M, Raynal P, Sobota A, Kwiatkowska K. | 01/21/2010 |
| PI4P5-K Ialpha-mediated PIP(2) production is crucial for HIV-1 entry and the early steps of infection in permissive lymphocytes. | PI4P5-kinase Ialpha is required for efficient HIV-1 entry and infection of T cells.
Barrero-Villar M, Barroso-González J, Cabrero JR, Gordón-Alonso M, Alvarez-Losada S, Muñoz-Fernández MA, Sánchez-Madrid F, Valenzuela-Fernández A. | 01/21/2010 |
| beta-arrestins direct the localization of PIP5K Ialpha and PIP(2) production to agonist-activated 7TMRs, thereby regulating receptor internalization | Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.
Nelson CD, Kovacs JJ, Nobles KN, Whalen EJ, Lefkowitz RJ., Free PMC Article | 01/21/2010 |
| Type I phosphatidylinositol-4-phosphate-5-kinase (PI5KI) alpha and gamma isoforms were identified as the enzymes responsible for PIP2 synthesis in natural killer cells. | PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway.
Micucci F, Capuano C, Marchetti E, Piccoli M, Frati L, Santoni A, Galandrini R. | 01/21/2010 |
| in addition to its effects upon Rac activity, Ajuba can also influence cell migration through regulation of PI(4,5)P2 synthesis through direct activation of PIPKIalpha enzyme activity | The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha.
Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD., Free PMC Article | 01/21/2010 |
| Membrane ruffling requires coordination between this enzyme and Rac signaling. | Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling.
Doughman RL, Firestone AJ, Wojtasiak ML, Bunce MW, Anderson RA. | 01/21/2010 |