| To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1.DENR to deliver initiator tRNA to ribosomes. | To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes.
Grove DJ, Russell PJ, Kearse MG., Free PMC Article | 03/5/2024 |
| Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits. | Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits.
Grove DJ, Levine DJ, Kearse MG., Free PMC Article | 02/5/2024 |
| Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed -1 ribosomal frameshifting. | Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed -1 ribosomal frameshifting.
Wei LH, Sun Y, Guo JU. | 09/20/2023 |
| The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D. | The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D.
Kim H, Aponte-Diaz D, Sotoudegan MS, Shengjuler D, Arnold JJ, Cameron CE., Free PMC Article | 02/13/2023 |
| PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells. | PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells.
Lee S, Jee HY, Lee YG, Shin JI, Jeon YJ, Kim JB, Seo HE, Lee JY, Lee K., Free PMC Article | 01/11/2023 |
| The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG*CAGG repeats. | The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG•CAGG repeats.
Tusi SK, Nguyen L, Thangaraju K, Li J, Cleary JD, Zu T, Ranum LPW., Free PMC Article | 03/5/2022 |
| Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2alpha phosphorylation and chemoresistance in colon cancer. | Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer.
Guo B, Xiong X, Hasani S, Wen YA, Li AT, Martinez R, Skaggs AT, Gao T., Free PMC Article | 02/5/2022 |
| CCCP-induced mitochondrial dysfunction - characterization and analysis of integrated stress response to cellular signaling and homeostasis. | CCCP-induced mitochondrial dysfunction - characterization and analysis of integrated stress response to cellular signaling and homeostasis.
Koncha RR, Ramachandran G, Sepuri NBV, Ramaiah KVA. | 10/16/2021 |
| MARK2 phosphorylates eIF2alpha in response to proteotoxic stress. | MARK2 phosphorylates eIF2α in response to proteotoxic stress.
Lu YN, Kavianpour S, Zhang T, Zhang X, Nguyen D, Thombre R, He L, Wang J., Free PMC Article | 07/31/2021 |
| The eIF2alpha kinase HRI in innate immunity, proteostasis, and mitochondrial stress. | The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress.
Girardin SE, Cuziol C, Philpott DJ, Arnoult D. | 07/24/2021 |
| Translation Regulation by eIF2alpha Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs). | Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs).
Rios-Fuller TJ, Mahe M, Walters B, Abbadi D, Pérez-Baos S, Gadi A, Andrews JJ, Katsara O, Vincent CT, Schneider RJ., Free PMC Article | 02/20/2021 |
| miR195 promotes LPSmediated intestinal epithelial cell apoptosis via targeting SIRT1/eIF2a. | miR‑195 promotes LPS‑mediated intestinal epithelial cell apoptosis via targeting SIRT1/eIF2a.
Yuan T, Zhang L, Yao S, Deng SY, Liu JQ., Free PMC Article | 09/12/2020 |
| This review summarizes the canonical roles of each branch of the integrated stress response (ISR_ and follow up with consideration and evidence of their implications in neurodegenerative pathologies. The maladaptive outcomes of ISR kinase activation and eIF2alpha phosphorylation, which might play mechanistic roles in neurodegeneration were also examined. [Review] | The Integrated Stress Response and Phosphorylated Eukaryotic Initiation Factor 2α in Neurodegeneration.
Bond S, Lopez-Lloreda C, Gannon PJ, Akay-Espinoza C, Jordan-Sciutto KL., Free PMC Article | 08/1/2020 |
| GADD45alpha is a key mediator of ER stress-induced growth arrest via regulation of the G2/M transition and cell death through the eIF2alpha signaling pathway. | ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α.
Lee D, Hokinson D, Park S, Elvira R, Kusuma F, Lee JM, Yun M, Lee SG, Han J., Free PMC Article | 05/2/2020 |
| A MYC-GCN2-eIF2alpha negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. | A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Schülein-Völk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer CT, Rosenwald A, Sansom OJ, Eilers M, Wiegering A., Free PMC Article | 02/22/2020 |
| PERK activation augments respiratory SCs. The PERK-eIF2alpha-ATF4 axis increases supercomplex assembly factor 1 (SCAF1 or COX7A2L), promoting SCs and enhanced mitochondrial respiration. PERK activation is sufficient to rescue bioenergetic defects caused by complex I missense mutations derived from mitochondrial disease patients. | ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis.
Balsa E, Soustek MS, Thomas A, Cogliati S, García-Poyatos C, Martín-García E, Jedrychowski M, Gygi SP, Enriquez JA, Puigserver P., Free PMC Article | 10/26/2019 |
| the endogenously produced product of inflammation, 15-deoxy-Delta(12,14)-prostaglandin J2 (15-d-PGJ2), triggers eIF2alpha phosphorylation, thereby activating the ISR, repressing bulk translation, and triggering SG formation. | 15-Deoxy-Δ(12,14)-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2α and activates the integrated stress response.
Tauber D, Parker R., Free PMC Article | 10/19/2019 |
| Our studies suggested that chelerythrine (CHE) possibly induces apoptosis through the nuclear translocation of MLKL and *MLKL, which is promoted by a mutual regulation between MLKL and PERK-eIF2alpha pathway in response to ROS formation. The present study clarified the new function of MLKL in apoptosis. | MLKL mediates apoptosis via a mutual regulation with PERK/eIF2α pathway in response to reactive oxygen species generation.
Cao WX, Li T, Tang ZH, Zhang LL, Wang ZY, Guo X, Su MX, Chen X, Lu JJ. | 09/28/2019 |
| Data show that high level of pancreatic endoplasmic reticulum kinase (PERK) and eukaryotic translation initiation factor 2A (p-eIF2[alpha]) expression in patients with pancreatic ductal adenocarcinoma (PDAC) correlated with poor survival. | Expression and Clinical Significance of Protein Kinase RNA-Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2α in Pancreatic Ductal Adenocarcinoma.
Wang EM, Akasaka H, Zhao J, Varadhachary GR, Lee JE, Maitra A, Fleming JB, Hung MC, Wang H, Katz MHG., Free PMC Article | 09/7/2019 |
| The data also support a potential role for the PERK/eIF2a/ATF4 axis in modulating cell viability in irradiated glioblastoma multiforme (GBM). The dual function of PERK as a mediator of survival and death may be exploited to enhance the efficacy of radiation therapy. | PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance.
Dadey DYA, Kapoor V, Khudanyan A, Thotala D, Hallahan DE. | 08/3/2019 |
| Study shows an anti-tumor function of the protein kinase PKR and its substrate eIF2alpha in a HER2+ breast cancer patient-derived xenograft mouse model. The anti-tumor function depends on the transcription factor ATF4, which upregulates the CDK inhibitor P21/CIP1 and activates JNK1/2. Also, the findings show that increased eIF2alpha-P is a surrogate biomarker of trastuzumab treatment. | An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy.
Darini C, Ghaddar N, Chabot C, Assaker G, Sabri S, Wang S, Krishnamoorthy J, Buchanan M, Aguilar-Mahecha A, Abdulkarim B, Deschenes J, Torres J, Ursini-Siegel J, Basik M, Koromilas AE., Free PMC Article | 06/15/2019 |
| Data suggest that neither eIF2A nor eIF2D are involved in the translation of this Sindbis virus subgenomic mRNA (sgmRNA) bearing non-AUG codons. | Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D.
Sanz MA, González Almela E, Carrasco L., Free PMC Article | 11/10/2018 |
| HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation. | HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation.
Huang Y, Sun Y, Cao Y, Sun H, Li M, You H, Su D, Li Y, Liang X., Free PMC Article | 07/28/2018 |
| POSTN may function as a protective factor for osteoblasts during this process by inhibiting the eIF2alphaATF4 pathway. | Periostin has a protective role in melatonin‑induced cell apoptosis by inhibiting the eIF2α‑ATF4 pathway in human osteoblasts.
Meng X, Zhu Y, Tao L, Zhao S, Qiu S. | 07/21/2018 |
| findings indicate that MSI1 plays a leading role in stress granule formation that grants cancer stem cell properties and chemoresistant stress granules in GBM, in response to stressful conditions via the PKR/eIF2alpha signalling cascade. | Musashi-1 promotes chemoresistant granule formation by PKR/eIF2α signalling cascade in refractory glioblastoma.
Chen HY, Lin LT, Wang ML, Tsai KL, Huang PI, Yang YP, Lee YY, Chen YW, Lo WL, Lan YT, Chiou SH, Lin CM, Ma HI, Chen MT. | 07/14/2018 |