| The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids. | The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids.
Thomas LD, Bandara S, Parmar VM, Srinivasagan R, Khadka N, Golczak M, Kiser PD, von Lintig J., Free PMC Article | 03/13/2021 |
| Evolutionary aspects and enzymology of metazoan carotenoid cleavage oxygenases. | Evolutionary aspects and enzymology of metazoan carotenoid cleavage oxygenases.
Poliakov E, Uppal S, Rogozin IB, Gentleman S, Redmond TM., Free PMC Article | 01/2/2021 |
| Enzymology of vertebrate carotenoid oxygenases. | Enzymology of vertebrate carotenoid oxygenases.
Harrison EH, Kopec RE., Free PMC Article | 01/2/2021 |
| Associations for BCO2, PCSK9, and TR1B1 Polymorphism and Lifestyle Factors with Ischemic Stroke | Associations for BCO2, PCSK9, and TR1B1 Polymorphism and Lifestyle Factors with Ischemic Stroke: A Nested Case-Control Study.
Zhao TY, Li Z, Lei S, Huang L, Yang L., Free PMC Article | 08/31/2019 |
| Study identifies BCO2 as a tumor suppressor in prostate cancer which mediates inhibition of NF-kB signaling. Its expression is decreased in human prostate cancer. | Mitochondrial β-Carotene 9',10' Oxygenase Modulates Prostate Cancer Growth via NF-κB Inhibition: A Lycopene-Independent Function.
Gong X, Marisiddaiah R, Zaripheh S, Wiener D, Rubin LP. | 08/5/2017 |
| review of molecular aspects in carotenoid metabolism and diseases | Molecular aspects of β, β-carotene-9', 10'-oxygenase 2 in carotenoid metabolism and diseases.
Wu L, Guo X, Wang W, Medeiros DM, Clarke SL, Lucas EA, Smith BJ, Lin D., Free PMC Article | 06/10/2017 |
| Role of beta-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism | Characterization of the Role of β-Carotene 9,10-Dioxygenase in Macular Pigment Metabolism.
Babino D, Palczewski G, Widjaja-Adhi MA, Kiser PD, Golczak M, von Lintig J., Free PMC Article | 01/16/2016 |
| Inactivity of human beta,beta-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment. | Inactivity of human β,β-carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment.
Li B, Vachali PP, Gorusupudi A, Shen Z, Sharifzadeh H, Besch BM, Nelson K, Horvath MM, Frederick JM, Baehr W, Bernstein PS., Free PMC Article | 09/20/2014 |
| a stepwise cleavage by BCO2 and BCO1 with APO10ol as an intermediate could provide a mechanism to tailor asymmetric carotenoids such as beta-cryptoxanthin for vitamin A production. | Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.
Amengual J, Widjaja-Adhi MAK, Rodriguez-Santiago S, Hessel S, Golczak M, Palczewski K, von Lintig J., Free PMC Article | 02/8/2014 |
| The gene encoding beta-carotene-9',10'-oxygenase, which cleaves the 9',10' double bond in beta-carotene into beta-apo-10'-carotenal, was cloned and expressed in Escherichia coli. | Production of β-apo-10'-carotenal from β-carotene by human β-carotene-9',10'-oxygenase expressed in E. coli.
Kim YS, Yeom SJ, Oh DK. | 08/27/2011 |
| we found that the third family member, beta,beta-carotene-9',10'-oxygenase (BCDO2), is a mitochondrial carotenoid-oxygenase with broad substrate specificity | A mitochondrial enzyme degrades carotenoids and protects against oxidative stress.
Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J., Free PMC Article | 04/30/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |