| Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions. | Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions.
López-Alcalá J, Gordon A, Trávez A, Tercero-Alcázar C, Correa-Sáez A, González-Rellán MJ, Rangel-Zúñiga OA, Rodríguez A, Membrives A, Frühbeck G, Nogueiras R, Calzado MA, Guzmán-Ruiz R, Malagón MM., Free PMC Article | 01/26/2024 |
| Pathogenic RAB34 variants impair primary cilium assembly and cause a novel oral-facial-digital syndrome. | Pathogenic RAB34 variants impair primary cilium assembly and cause a novel oral-facial-digital syndrome.
Bruel AL, Ganga AK, Nosková L, Valenzuela I, Martinovic J, Duffourd Y, Zikánová M, Majer F, Kmoch S, Mohler M, Sun J, Sweeney LK, Martínez-Gil N, Thauvin-Robinet C, Breslow DK., Free PMC Article | 09/11/2023 |
| Rab34 plays a critical role as a bidirectional regulator of osteoclastogenesis. | Rab34 plays a critical role as a bidirectional regulator of osteoclastogenesis.
Feng Y, Tran MT, Lu Y, Htike K, Okusha Y, Sogawa C, Eguchi T, Kadowaki T, Sakai E, Tsukuba T, Okamoto K. | 04/30/2022 |
| Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway. | Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK., Free PMC Article | 03/5/2022 |
| A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis. | A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis.
Oguchi ME, Okuyama K, Homma Y, Fukuda M., Free PMC Article | 02/2/2021 |
| Authors demonstrate that endocytic recycling protein Rab34 localizes to cilia, and that its mutation results in significant decrease of ciliogenesis in both cultured cells and mice. Rab34 is required for the successive fusion of preciliary vesicles to generate ciliary vesicles and for the migration of the mother centriole from perinuclear region to plasma membrane. | Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse.
Xu S, Liu Y, Meng Q, Wang B., Free PMC Article | 01/11/2020 |
| Silencing Rab34 by shRNA inhibits cell migration, invasion, and adhesion of breast cancer cells. | Rab34 regulates adhesion, migration, and invasion of breast cancer cells.
Sun L, Xu X, Chen Y, Zhou Y, Tan R, Qiu H, Jin L, Zhang W, Fan R, Hong W, Wang T. | 03/9/2019 |
| The present study demonstrated that RAB34 plays an important role in the initiation and progression of hepatocellular carcinoma (HCC). Our results suggest a new therapeutic target for the clinical treatment of HCC. | Overexpression of RAB34 correlates with poor prognosis and tumor progression in hepatocellular carcinoma.
Wu J, Lu Y, Qin A, Qiao Z, Jiang X. | 07/7/2018 |
| Rab34 activity is modulated by SopD2 and is required for maturation of the Salmonella containing vacuole. | Salmonella effector SopD2 interferes with Rab34 function.
Teo WX, Yang Z, Kerr MC, Luo L, Guo Z, Alexandrov K, Stow JL, Teasdale RD. | 04/1/2017 |
| NARR is ubiquitously expressed and resides in nucleoli where it colocalizes with ribosomal DNA gene clusters. | Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene.
Zougman A, Mann M, Wisniewski JR., Free PMC Article | 12/13/2016 |
| MMP19 were positively correlated with RAB34. | RAB34 was a progression- and prognosis-associated biomarker in gliomas.
Wang HJ, Gao Y, Chen L, Li YL, Jiang CL. | 06/20/2015 |
| Although Rab34 regulates both lysosomal positioning and lysosome to phagosome fusion, the latter effect is not due to the regulation of the cytoplasmic accessibility of lysosomes to phagosomes by Rab34. | Spatial distribution of phagolysosomes is independent of the regulation of lysosome position by Rab34.
Kasmapour B, Cai L, Gutierrez MG. | 06/7/2014 |
| Rab36 may regulate the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34. | Rab36 regulates the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34.
Chen L, Hu J, Yun Y, Wang T. | 03/1/2010 |
| mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34, indicating a potentially critical role for this newly described pathway in the pathogenesis of DN. | Rab34 and its effector munc13-2 constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia.
Goldenberg NM, Silverman M. | 01/21/2010 |
| define Rab34 as a novel member of the secretory pathway acting at the Golgi | Golgi-bound Rab34 is a novel member of the secretory pathway.
Goldenberg NM, Grinstein S, Silverman M., Free PMC Article | 01/21/2010 |
| B coxsackievirus entry depends on occludin and require the activity of Rab34, Ras, and Rab5, GTPases known to regulate macropinocytosis. | Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.
Coyne CB, Shen L, Turner JR, Bergelson JM., Free PMC Article | 01/21/2010 |
| The data together indicate that RILP, as already demonstrated for several other Rab effector proteins, is capable of self-association, thus probably forming a homo-dimer. | The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction.
Colucci AM, Campana MC, Bellopede M, Bucci C. | 01/21/2010 |
| Data suggest that diacylglycerol-activated hmunc13 serves as an effector of Rab34, mediating lysosome-Golgi trafficking. | Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34.
Speight P, Silverman M. | 01/21/2010 |