| E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin Tumorigenesis by Inhibiting IL-6/GP130 Signaling Pathway. | E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin Tumorigenesis by Inhibiting IL-6/GP130 Signaling Pathway.
Liu H, Wang N, Yang R, Luan J, Cao M, Zhai C, Wang S, Wei M, Wang D, Qiao J, Liu Y, She W, Guo N, Liao B, Gou X. | 10/25/2024 |
| Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKbeta in diabetic kidney disease. | Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKβ in diabetic kidney disease.
Han F, Wu S, Dong Y, Liu Y, Sun B, Chen L., Free PMC Article | 08/15/2024 |
| METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke. | METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.
Su W, Yu X, Wang S, Wang X, Dai Z, Li Y., Free PMC Article | 02/12/2024 |
| E3 ligase Nedd4L promotes macrophage M1 polarization and exacerbates brain damage by TRAF3/TBK1 signaling pathway after ICH in mice. | E3 ligase Nedd4L promotes macrophage M1 polarization and exacerbates brain damage by TRAF3/TBK1 signaling pathway after ICH in mice.
Xia X, Yang Z, Zhang J, Fu X, Han B, Xiong Q, Yu A. | 01/10/2024 |
| Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity. | Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.
Altas B, Rhee HJ, Ju A, Solís HC, Karaca S, Winchenbach J, Kaplan-Arabaci O, Schwark M, Ambrozkiewicz MC, Lee C, Spieth L, Wieser GL, Chaugule VK, Majoul I, Hassan MA, Goel R, Wojcik SM, Koganezawa N, Hanamura K, Rotin D, Pichler A, Mitkovski M, de Hoz L, Poulopoulos A, Urlaub H, Jahn O, Saher G, Brose N, Rhee J, Kawabe H., Free PMC Article | 12/1/2023 |
| Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension. | Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension.
Mohammed M, Ogunlade B, Elgazzaz M, Berdasco C, Lakkappa N, Ghita I, Guidry JJ, Sriramula S, Xu J, Restivo L, Mendiola Plá MA, Bowles DE, Beyer AM, Yue X, Lazartigues E, Filipeanu CM., Free PMC Article | 09/7/2023 |
| Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1. | Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.
Gu X, Meng H, Peng C, Lin S, Li B, Zhao L, Yang X, Wang G, Cai W, Zhou J, Liu S, Wu P, Du Y, Jin J, Wang X., Free PMC Article | 06/23/2023 |
| NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway. | NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.
Wu Q, Zhang H, You S, Xu Z, Liu X, Chen X, Zhang W, Ye J, Li P, Zhou X. | 06/23/2023 |
| A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis. | A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis.
Guo Q, Xin M, Lu Q, Feng D, Yang V, Peng LF, Whelan KA, Hu W, Wu S, Yang X, Wang H, Rothberg BS, Gamero AM, Gerhard GS, Gao B, Yang L., Free PMC Article | 05/12/2023 |
| E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2. | E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2.
Li H, Wang N, Jiang Y, Wang H, Xin Z, An H, Pan H, Ma W, Zhang T, Wang X, Lin W., Free PMC Article | 11/19/2022 |
| Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination. | Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination.
Hu XW, Li XM, Wang AM, Fu YM, Zhang FJ, Zeng F, Cao LP, Long H, Xiong YH, Xu J, Li J. | 11/5/2022 |
| E3 ubiquitin ligase Nedd4-2 exerts neuroprotective effects during endoplasmic reticulum stress. | E3 ubiquitin ligase Nedd4-2 exerts neuroprotective effects during endoplasmic reticulum stress.
Lodes DE, Zhu J, Tsai NP., Free PMC Article | 05/7/2022 |
| 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. | 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains.
Pohl P, Joshi R, Petrvalska O, Obsil T, Obsilova V., Free PMC Article | 11/13/2021 |
| Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling. | Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling.
Lee KY, Zhu J, Cutia CA, Christian-Hinman CA, Rhodes JS, Tsai NP., Free PMC Article | 10/30/2021 |
| Deletion of renal Nedd4-2 abolishes the effect of high K(+) intake on Kir4.1/Kir5.1 and NCC activity in the distal convoluted tubule. | Deletion of renal Nedd4-2 abolishes the effect of high K(+) intake on Kir4.1/Kir5.1 and NCC activity in the distal convoluted tubule.
Xiao Y, Duan XP, Zhang DD, Wang WH, Lin DH., Free PMC Article | 09/18/2021 |
| Unbiased proteomic screening identifies a novel role for the E3 ubiquitin ligase Nedd4-2 in translational suppression during ER stress. | Unbiased proteomic screening identifies a novel role for the E3 ubiquitin ligase Nedd4-2 in translational suppression during ER stress.
Eagleman DE, Zhu J, Liu DC, Seimetz J, Kalsotra A, Tsai NP., Free PMC Article | 08/28/2021 |
| Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2. | Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2.
Engelmann TA, Knudsen L, Leitz DHW, Duerr J, Beers MF, Mall MA, Ochs M., Free PMC Article | 08/14/2021 |
| Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice. | Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice.
Leitz DHW, Duerr J, Mulugeta S, Seyhan Agircan A, Zimmermann S, Kawabe H, Dalpke AH, Beers MF, Mall MA., Free PMC Article | 07/31/2021 |
| The ubiquitin E3 ligase Nedd4-2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice. | The ubiquitin E3 ligase Nedd4-2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice.
Wang S, Qi S, Kogure Y, Kanda H, Tian L, Yamamoto S, Noguchi K, Dai Y. | 07/17/2021 |
| E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3. | E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.
Gao P, Ma X, Yuan M, Yi Y, Liu G, Wen M, Jiang W, Ji R, Zhu L, Tang Z, Yu Q, Xu J, Yang R, Xia S, Yang M, Pan J, Yuan H, An H., Free PMC Article | 03/13/2021 |
| Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule. | Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule.
Wu P, Su XT, Gao ZX, Zhang DD, Duan XP, Xiao Y, Staub O, Wang WH, Lin DH., Free PMC Article | 01/9/2021 |
| Neddylation-mediated Nedd4-2 activation regulates ubiquitination modification of renal NBCe1. | Neddylation-mediated Nedd4-2 activation regulates ubiquitination modification of renal NBCe1.
Tu J, Zhang B, Fang G, Chang W, Zhao Y. | 12/12/2020 |
| Downregulation of MicroRNA-494 inhibits the TGF-beta1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L. | Downregulation of MicroRNA-494 inhibits the TGF-β1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L.
Tian RH, Guo KM, Han GH, Bai Y. | 10/31/2020 |
| Study shows that conditional deletion of the ubiquitin ligase Nedd4-2 (Nedd4l) in lung epithelial cells in adult mice produces chronic lung disease sharing key features with idiopathic pulmonary fibrosis including progressive fibrosis and bronchiolization with increased expression of Muc5b in peripheral airways, honeycombing and characteristic alterations in the lung proteome. | Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.
Duerr J, Leitz DHW, Szczygiel M, Dvornikov D, Fraumann SG, Kreutz C, Zadora PK, Seyhan Agircan A, Konietzke P, Engelmann TA, Hegermann J, Mulugeta S, Kawabe H, Knudsen L, Ochs M, Rotin D, Muley T, Kreuter M, Herth FJF, Wielpütz MO, Beers MF, Klingmüller U, Mall MA., Free PMC Article | 08/15/2020 |
| NEDD4L is an E3 ubiquitin ligase of bestrophin-1. WW3-4 domains of NEDD4L are required for the interaction with bestrophin-1. | The E3 ubiquitin ligase, NEDD4L (NEDD4-2) regulates bestrophin-1 (BEST1) by ubiquitin-dependent proteolysis.
Park M, Jung HG, Kweon HJ, Kim YE, Park JY, Hwang EM. | 07/25/2020 |