| Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome. | Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome.
Hisama FM, Pillai RK, Sidorova J, Patterson K, Gokingco C, Yacobi-Bach M, Oshima J., Free PMC Article | 02/1/2024 |
| Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis. | Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis.
Pan J, Zhao L, Liu J, Wang G., Free PMC Article | 03/5/2022 |
| CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study. | CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study.
Rahmati Y, Mollanoori H, Najafi S, Esmaeili S, Alivand MR., Free PMC Article | 01/29/2022 |
| SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade. | SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade.
Wang X, Ni J, You Y, Feng G, Zhang S, Bao W, Hou H, Li H, Liu L, Zheng M, Wang Y, Zhou H, Shen W, Shen X., Free PMC Article | 12/25/2021 |
| The in vitro application of cyclic stretching induced programmed cell death by activation of caspase-3 and -5 in periodontal ligament cells, and these two caspases could interact with each other after mechanical stretch loading. | Interaction between caspase-3 and caspase-5 in the stretch-induced programmed cell death in the human periodontal ligament cells.
Wu Y, Zhuang J, Zhao D, Xu C. | 05/30/2020 |
| Knockdown of caspase-4/5 preserved human tubular epithelial cells from cell death and reduced the release of mature IL-1beta. | Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury.
Zhang Z, Shao X, Jiang N, Mou S, Gu L, Li S, Lin Q, He Y, Zhang M, Zhou W, Ni Z., Free PMC Article | 12/14/2019 |
| Long non-coding RNA CASP5 promotes the malignant phenotypes of human glioblastoma multiforme. | Long non-coding RNA CASP5 promotes the malignant phenotypes of human glioblastoma multiforme.
Zhou Y, Dai W, Wang H, Pan H, Wang Q. | 09/8/2018 |
| Study shows that CASP5 was positively correlated with inflammation in rheumatoid arthritis (RA), and provides evidence that certain CASP5 SNPs were associated with an increased risk of RA. | The association between caspase-5 gene polymorphisms and rheumatoid arthritis in a Chinese population.
Rui H, Yan T, Hu Z, Liu R, Wang L. | 12/23/2017 |
| Th17 micro-milieu via IL-17A regulates NLRP1-dependent CASP5 activity in psoriatic skin autoinflammation. | Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation.
Zwicker S, Hattinger E, Bureik D, Batycka-Baran A, Schmidt A, Gerber PA, Rothenfusser S, Gilliet M, Ruzicka T, Wolf R., Free PMC Article | 04/29/2017 |
| CASP5 gene overexpression significantly promoted angiogenesis ability of HMEC-1 cells, which was probably achieved by inhibiting angpt-1/Tie2 and promoting VEGF-1 signal pathway. | Effects of CASP5 gene overexpression on angiogenesis of HMEC-1 cells.
Li H, Li Y, Cai L, Bai B, Wang Y., Free PMC Article | 11/5/2016 |
| Caspase-4 and caspase-5 mediate IL-1alpha and IL-1beta release from human monocytes after lipopolysaccharides stimulation. | Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.
Viganò E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A., Free PMC Article | 05/21/2016 |
| The distribution of the other genotypes; rs507879, rs518604 and rs523104 of caspase-5) was not significantly different between patients with psoriasis vulgaris and the healthy controls. | Association of angiopoietin-1, angiopoietin-2 and caspase-5 polymorphisms with psoriasis vulgaris.
He L, Dang L, Zhou J, Bai J, Li YZ. | 04/2/2016 |
| both caspase-4 and caspase-5 are functionally important for appropriate responses to intracellular Gram-negative bacteria. | NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Baker PJ, Boucher D, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K, Masters SL. | 01/16/2016 |
| this study has identified epithelial-expressed caspases-4 and -5 as biomarkers with diagnostic and therapeutic potential in colorectal cancer. | Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.
Flood B, Oficjalska K, Laukens D, Fay J, O'Grady A, Caiazza F, Heetun Z, Mills KH, Sheahan K, Ryan EJ, Doherty GA, Kay E, Creagh EM., Free PMC Article | 08/29/2015 |
| Data show that exposure of hepatocytes to direct hypoxia resulted in acid sphingomyelinase activation and ceramide elevation associated with activation of caspase 5 and the subsequent cleavage of HuR and apoptotic cell death. | The role of acid sphingomyelinase and caspase 5 in hypoxia-induced HuR cleavage and subsequent apoptosis in hepatocytes.
Zhu Q, Lin L, Cheng Q, Xu Q, Zhang J, Tomlinson S, Jin J, Chen X, He S. | 02/2/2013 |
| Data suggest a positive association of caspase-3 and diplotype analysis of caspase-5 to be associated with prostate cancer risk. | Association of caspases with an increased prostate cancer risk in north Indian population.
Mittal RD, Mittal T, Singh AK, Mandal RK. | 03/24/2012 |
| Mutual activation between caspase-5 and -1 suggests caspase-5 may work predominantly in concert with caspase-1 in modulating retinal pigment epithelium inflammatory responses. | Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells.
Bian ZM, Elner SG, Khanna H, Murga-Zamalloa CA, Patil S, Elner VM., Free PMC Article | 01/7/2012 |
| Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians. | Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians.
Mittal RD, Srivastava P, Mittal T, Verma A, Jaiswal PK, Singh V, Mandal RK, Mandhani A. | 09/3/2011 |
| analysis of concerted antigen processing of a short viral antigen by human caspase-5 and -10 | Concerted antigen processing of a short viral antigen by human caspase-5 and -10.
López D, Jiménez M, García-Calvo M, Del Val M., Free PMC Article | 07/16/2011 |
| Caspase-5 and the inflammasome may have an important role in the inflammatory response in psoriasis. | Caspase-5 expression is upregulated in lesional psoriatic skin.
Salskov-Iversen ML, Johansen C, Kragballe K, Iversen L. | 04/16/2011 |
| The changes of caspase-2 and caspase-5 activities could be indicative of their involvement in the cervical malignancy mechanisms. | Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy.
Babas E, Ekonomopoulou MT, Karapidaki I, Doxakis A, Betsas G, Iakovidou-Kritsi Z. | 02/26/2011 |
| Unfavorable significance of CASP5 heterozygous genotype explained by its role in inflammation-related processes. | Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects.
Ulybina YM, Kuligina ESh, Mitiushkina NV, Sherina NY, Yanus GA, Gorodnova TV, Katanugina AS, Koloskov AV, Togo AV, Imyanitov EN. | 01/1/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
O'Doherty C, Favorov A, Heggarty S, Graham C, Favorova O, Ochs M, Hawkins S, Hutchinson M, O'Rourke K, Vandenbroeck K., Free PMC Article | 09/16/2009 |
| Single nucleotide polymorphisms in CASP5 and RBBP8 gene are associated with survival in ovarian cancer patients. | Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.
Quaye L, Dafou D, Ramus SJ, Song H, Gentry-Maharaj A, Notaridou M, Hogdall E, Kjaer SK, Christensen L, Hogdall C, Easton DF, Jacobs I, Menon U, Pharoah PD, Gayther SA. | 01/21/2010 |