MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population. | MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population. Liu X, Xie H, Fu Z, Yao Q, Han T, Zhan D, Lin Z, Zhu H., Free PMC Article | 07/25/2024 |
The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma. | The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma. Luo H, Huang K, Cheng M, Long X, Zhu X, Wu M., Free PMC Article | 11/7/2023 |
Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex. | Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex. Goo BS, Mun DJ, Kim S, Nhung TTM, Lee SB, Woo Y, Kim SJ, Suh BK, Park SJ, Lee HE, Park K, Jang H, Rah JC, Yoon KJ, Baek ST, Park SY, Park SK., Free PMC Article | 02/14/2023 |
Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression. | Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression. Sokolov AV, Manu DM, Nordberg DOT, Boström ADE, Jokinen J, Schiöth HB., Free PMC Article | 01/14/2023 |
Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk. | Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk. McKinney BC, McClain LL, Hensler CM, Wei Y, Klei L, Lewis DA, Devlin B, Wang J, Ding Y, Sweet RA., Free PMC Article | 09/3/2022 |
The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells. | The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells. Dahiya NR, Leibovitch BA, Kadamb R, Bansal N, Waxman S., Free PMC Article | 04/30/2022 |
Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80. | Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80. Xiao M, Li X, Su Y, Liu Z, Han Y, Wang S, Zeng Q, Liu H, Hao J, Xu B., Free PMC Article | 12/4/2021 |
Prognostic Significance of the MAD1L1 1673 G: A Polymorphism in Ovarian Adenocarcinomas. | Prognostic Significance of the MAD1L1 1673 G: A Polymorphism in Ovarian Adenocarcinomas. Bandala-Jacques A, Hernández-Cruz IA, Castro-Hernández C, Díaz-Chávez J, Arriaga-Canon C, Barquet-Muñoz SA, Prada-Ortega DG, Cantú-de León D, Herrera LA. | 11/6/2021 |
Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint. | Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint. Allan LA, Camacho Reis M, Ciossani G, Huis In 't Veld PJ, Wohlgemuth S, Kops GJ, Musacchio A, Saurin AT., Free PMC Article | 04/13/2021 |
Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint. | Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint. Jackman M, Marcozzi C, Barbiero M, Pardo M, Yu L, Tyson AL, Choudhary JS, Pines J., Free PMC Article | 03/20/2021 |
Association of MAD1L1 polymorphism (rs871925) with prenatal famine exposure and schizophrenia in a Chinese population: A case-control study. | Association of MAD1L1 polymorphism (rs871925) with prenatal famine exposure and schizophrenia in a Chinese population: A case-control study. Sun Y, Kang G, Zhu X, Li R, Kang Q, Zhang M, Wang Y, Chen X, Yu Y, Yu Q. | 10/24/2020 |
We identified and replicated three new genome-wide significant signals of association with idiopathic pulmonary fibrosis susceptibility (associated with altered gene expression of KIF15, MAD1L1, and DEPTOR). New signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility. | Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis. Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M, Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Whyte MKB, Zhang Y, Kaminski N, Adegunsoye A, Strek ME, Neighbors M, Sheng XR, Gudmundsson G, Gudnason V, Hatabu H, Lederer DJ, Manichaikul A, Newell JD Jr, O'Connor GT, Ortega VE, Xu H, Fingerlin TE, Bossé Y, Hao K, Joubert P, Nickle DC, Sin DD, Timens W, Furniss D, Morris AP, Zondervan KT, Hall IP, Sayers I, Tobin MD, Maher TM, Cho MH, Hunninghake GM, Schwartz DA, Yaspan BL, Molyneaux PL, Flores C, Noth I, Jenkins RG, Wain LV., Free PMC Article | 05/23/2020 |
MAD1-dependent pool of CDK1-CCNB1 creates a positive feedback loop necessary for timely recruitment of MPS1 to kinetochores during mitotic entry and for sustained spindle checkpoint arrest. CDK1-CCNB1 is therefore an integral component of the spindle checkpoint, ensuring the fidelity of mitosis. | MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling. Alfonso-Pérez T, Hayward D, Holder J, Gruneberg U, Barr FA., Free PMC Article | 04/18/2020 |
Autophagy-related protein 1 homolog (ULK1) phosphorylates the spindle assembly checkpoint (SAC) protein mitotic arrest deficient 1-like 1 protein (Mad1) at Ser546 to recruit Mad1 to kinetochores. | ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint. Yuan F, Jin X, Li D, Song Y, Zhang N, Yang X, Wang L, Zhu WG, Tian C, Zhao Y., Free PMC Article | 12/14/2019 |
we demonstrated the presence of the recurrent RARS-MAD1L1 gene fusion in NPC. Furthermore, we provided the first evidence showing that the RARS-MAD1L1 fusion gene enhances tumorigenicity, CSC-like properties, and therapeutic resistance | The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma. Zhong Q, Liu ZH, Lin ZR, Hu ZD, Yuan L, Liu YM, Zhou AJ, Xu LH, Hu LJ, Wang ZF, Guan XY, Hao JJ, Lui VWY, Guo L, Mai HQ, Chen MY, Han F, Xia YF, Grandis JR, Zhang X, Zeng MS., Free PMC Article | 07/27/2019 |
Study provides additional support for prior association findings in FADS1, MAD1L1, SCN2A, and ITIH3, and have confirmed a risk locus at 10q26.13 that is associated with bipolar disorder. | Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population. Zhao L, Chang H, Zhou DS, Cai J, Fan W, Tang W, Tang W, Li X, Liu W, Liu F, He Y, Bai Y, Sun Y, Dai J, Li L, Xiao X, Zhang C, Li M., Free PMC Article | 05/11/2019 |
Upregulation of Mad1 accelerates growth of orthotopic mammary tumors, which show decreased levels of p53 and its downstream effector p21. | Mad1 destabilizes p53 by preventing PML from sequestering MDM2. Wan J, Block S, Scribano CM, Thiry R, Esbona K, Audhya A, Weaver BA., Free PMC Article | 05/4/2019 |
Data suggest that LMO7 interacts with MAD1 during spindle assembly phase of mitosis; LMO7 plays role in control of mitosis progression and exerts effect on spindle assembly checkpoint; LMO7 colocalizes with actin filaments; LMO7 does not colocalize with MAD1 at kinetochores in prometaphase nor at spindle poles in metaphase. (LMO7 = LIM domain only protein-7; MAD1 = mitotic spindle assembly checkpoint protein MAD1) | LMO7 exerts an effect on mitosis progression and the spindle assembly checkpoint. Tzeng YW, Li DY, Chen Y, Yang CH, Chang CY, Juang YL. | 10/20/2018 |
Therefore, Mps1 promotes checkpoint activation through sequentially phosphorylating Knl1, Bub1, and Mad1. This sequential multi-target phosphorylation cascade makes the checkpoint highly responsive to Mps1 and to kinetochore-microtubule attachment. | A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling. Ji Z, Gao H, Jia L, Li B, Yu H., Free PMC Article | 02/10/2018 |
This study showed that MAD1L1 as a susceptibility gene for both of these genetically overlapping disorders is associated with a decreased bottom-up responsiveness of the mesolimbic reward system and related cortical regions involved in the salience network as well as with reduced top-down control processes. | Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System. Trost S, Diekhof EK, Mohr H, Vieker H, Krämer B, Wolf C, Keil M, Dechent P, Binder EB, Gruber O., Free PMC Article | 09/2/2017 |
Results show that low DNA methylation levels of LINC00682, MAD1L1, and LINE-2 was strongly correlated with hepatocellular carcinomas recurrence, patient disease-free survival, and/or overall survival. | Genome-wide identification of differential methylation between primary and recurrent hepatocellular carcinomas. Cui C, Lu Z, Yang L, Gao Y, Liu W, Gu L, Yang C, Wilson J, Zhang Z, Xing B, Deng D, Sun ZS. | 07/29/2017 |
MAD1L1 positive expression may be associated with tumour progression and metastasis in small-cell lung cancer (SCLC) and may thus serve as a new biomarker for prognosis in these patients. | Mitotic arrest deficient-like 1 is correlated with poor prognosis in small-cell lung cancer after surgical resection. Li D, Meng Q, Zhang H, Feng T, Liu M, Cai L. | 02/4/2017 |
In this review, we highlight a novel Mad1 role in chromosome alignment, which is the first conserved mechanism that links the spindle assembly checkpoint and kinesin-mediated chromosome gliding. | The spindle assembly checkpoint promotes chromosome bi-orientation: A novel Mad1 role in chromosome alignment. Akera T, Watanabe Y., Free PMC Article | 12/17/2016 |
MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer | MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer. Zhong R, Chen X, Chen X, Zhu B, Lou J, Li J, Shen N, Yang Y, Gong Y, Zhu Y, Yuan J, Xia X, Miao X., Free PMC Article | 08/13/2016 |
MAD1L1 rs12666575 polymorphism may play a protective role against schizophrenia (SCZ) in the Chinese population. rs12666575 may be associated with general psychopathology and thought disturbance in SCZ patients. | Genetic association of GWAS-supported MAD1L1 gene polymorphism rs12666575 with schizophrenia susceptibility in a Chinese population. Su L, Shen T, Huang G, Long J, Fan J, Ling W, Jiang J. | 05/14/2016 |