| Decreased CRISPLD2 expression impairs osteogenic differentiation of human mesenchymal stem cells during in vitro expansion. | Decreased CRISPLD2 expression impairs osteogenic differentiation of human mesenchymal stem cells during in vitro expansion.
Rong W, Rome CP, Dietrich MA, Yao S., Free PMC Article | 06/21/2023 |
| Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma. | Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.
Lavictoire SJ, Jomaa D, Gont A, Jardine K, Cook DP, Lorimer IAJ., Free PMC Article | 12/18/2021 |
| Our findings suggest that using specific asthma characteristics, such as airway hyperresponsiveness, can help identify more genetically homogeneous asthma subgroups with genotype-phenotype associations that may not be observed in all children with asthma. CRISPLD2 also may be important for baseline lung function in individuals with asthma who also may have airway hyperresponsiveness. | Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.
Kachroo P, Hecker J, Chawes BL, Ahluwalia TS, Cho MH, Qiao D, Kelly RS, Chu SH, Virkud YV, Huang M, Barnes KC, Burchard EG, Eng C, Hu D, Celedón JC, Daya M, Levin AM, Gui H, Williams LK, Forno E, Mak ACY, Avila L, Soto-Quiros ME, Cloutier MM, Acosta-Pérez E, Canino G, Bønnelykke K, Bisgaard H, Raby BA, Lange C, Weiss ST, Lasky-Su JA, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium., Free PMC Article | 05/30/2020 |
| CRISPLD2 rs4783099 was associated with cleft lip and/or palate (CL/P) statistically (OR = 3.18, P < .01). Compared to genotype TT, genotypes CC and CT were correlated significantly (OR = 2.04, P = .04) with CL/P. No evidence showed an association between genetic variation at the CRISPLD2 locus and cleft palate only (CP). | Association Between CRISPLD2 Polymorphisms and the Risk of Nonsyndromic Clefts of the Lip and/or Palate: A Meta-analysis.
Ge X, Shi QM, Ding Z, Ju Q, Wang H, Wang Q, Li MX, Chen G, Wang HX, Xu LC. | 06/8/2019 |
| we demonstrated that knockdown of Crispld2 in zebrafish alters neural crest cell migration patterns resulting in abnormal jaw and palate development. In this study, we performed RNA profiling in zebrafish embryos and identified 249 differentially expressed genes following knockdown of Crispld2. | Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes.
Chiquet BT, Yuan Q, Swindell EC, Maili L, Plant R, Dyke J, Boyer R, Teichgraeber JF, Greives MR, Mulliken JB, Letra A, Blanton SH, Hecht JT., Free PMC Article | 03/9/2019 |
| Our results suggest that CRISPLD2 rs4783099 may represent a risk factor for NSCPO (non-syndromic oral clefts). | Brazilian multicenter study of association between polymorphisms in CRISPLD2 and JARID2 and non-syndromic oral clefts.
Messetti AC, Machado RA, de Oliveira CE, Martelli-Júnior H, de Almeida Reis SR, Moreira HS, Persuhn DC, Wu T, Coletta RD. | 02/17/2018 |
| Data suggest that suppression of CRISPLD2 increases the risk of lung inflammation in early life and adulthood. | CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells.
Zhang H, Kho AT, Wu Q, Halayko AJ, Limbert Rempel K, Chase RP, Sweezey NB, Weiss ST, Kaplan F., Free PMC Article | 10/28/2017 |
| Our data suggest that CRISPLD2 may have a unique anti-HMGB1 effect via miRNA155 and play an important role in immune balance. | HMGB1 induced inflammatory effect is blocked by CRISPLD2 via MiR155 in hepatic fibrogenesis.
Zhang H, Liu Z, Liu S. | 05/14/2016 |
| CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. | CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis.
Yoo JY, Shin H, Kim TH, Choi WS, Ferguson SD, Fazleabas AT, Young SL, Lessey BA, Ha UH, Jeong JW., Free PMC Article | 11/7/2015 |
| Results demonstrate genetic polymorphism of CRISPLD2 gene is associated with an increased risk of non-syndromic cleft lip with or without cleft palate. | Preliminary evidence of an interaction between the CRISPLD2 gene and non-syndromic cleft lip with or without cleft palate (nsCL/P) in Xinjiang Uyghur population, China.
Mijiti A, Ling W, Maimaiti A, Tuerdi M, Tuerxun J, Moming A. | 10/24/2015 |
| findings define a role for LGL1 in fibroblast expansion and migration, epithelial cell migration, and mesenchymal-epithelial signaling, key processes in fetal lung development. | LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts.
Zhang H, Sweezey NB, Kaplan F. | 04/11/2015 |
| results support the hypothesis that variants in the CRISPLD2 gene may be involved in the etiology of NS CL(P). | CRISPLD2 variants including a C471T silent mutation may contribute to nonsyndromic cleft lip with or without cleft palate.
Letra A, Menezes R, Cooper ME, Fonseca RF, Tropp S, Govil M, Granjeiro JM, Imoehl SR, Mansilla MA, Murray JC, Castilla EE, Orioli IM, Czeizel AE, Ma L, Chiquet BT, Hecht JT, Vieira AR, Marazita ML, Letra A, Menezes R, Cooper ME, Fonseca RF, Tropp S, Govil M, Granjeiro JM, Imoehl SR, Mansilla MA, Murray JC, Castilla EE, Orioli IM, Czeizel AE, Ma L, Chiquet BT, Hecht JT, Vieira AR, Marazita ML., Free PMC Articles: PMC3000893, PMC3000893 | 10/4/2014 |
| Both LCCL-domains of human CRISPLD2 have high affinity for lipid A. | Both LCCL-domains of human CRISPLD2 have high affinity for lipid A.
Vásárhelyi V, Trexler M, Patthy L. | 08/30/2014 |
| There is a decreased expression of CRISPLD2 in septic shock and it is association with procalcitonin in sepsis. | CRISPLD2 is expressed at low levels during septic shock and is associated with procalcitonin.
Wang T, Wang ZQ, Wang L, Yan L, Wan J, Zhang S, Jiang HQ, Li WF, Lin ZF., Free PMC Article | 02/1/2014 |
| CRISPLD2 gene contributes to the etiology of NSCLP in the Northwestern Chinese population. SNP rs1546124 is significantly related to NSCLP, associated with both CL/P and CPO groups, and SNP rs4783099 is significantly associated with CPO. | The CRISPLD2 gene is involved in cleft lip and/or cleft palate in a Chinese population.
Shen X, Liu RM, Yang L, Wu H, Li PQ, Liang YL, Xie XD, Yao T, Zhang TT, Yu M. | 12/24/2011 |
| These novel findings suggest that CRISPLD1 plays a role in Nonsyndromic cleft lip and palate (NSCLP) through the interaction with CRISPLD2 and folate pathway genes. | Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection.
Chiquet BT, Henry R, Burt A, Mulliken JB, Stal S, Blanton SH, Hecht JT., Free PMC Article | 05/28/2011 |
| the present investigation did not support the hypothesis of the involvement of CRISPLD2 in nonsyndromic cleft lip and palate | No evidence for a role of CRISPLD2 in non-syndromic cleft lip with or without cleft palate in an Italian population.
Girardi A, Martinelli M, Carinci F, Morselli PG, Caramelli E, Scapoli L. | 05/21/2011 |
| three SNPs in northern Chinese population found an association between these polymorphisms and NSCLP in both single-marker and haplotype analyses. data further strengthen the conclusion that altered CRISPLD2 is associated with NSCLP susceptibility. | CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population.
Shi J, Jiao X, Song T, Zhang B, Qin C, Cao F, Shi J, Jiao X, Song T, Zhang B, Qin C, Cao F. | 12/11/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| present work introduces mammal CRISPLD2 as a major serum protein that acts as a natural LPS antagonist and promises to be of considerable preventative value against endotoxic shock. | The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin function.
Wang ZQ, Xing WM, Fan HH, Wang KS, Zhang HK, Wang QW, Qi J, Yang HM, Yang J, Ren YN, Cui SJ, Zhang X, Liu F, Lin DH, Wang WH, Hoffmann MK, Han ZG. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesCRISPLD2 variants including a C471T silent mutation may contribute to nonsyndromic cleft lip with or without cleft palate.
Letra A, Menezes R, Cooper ME, Fonseca RF, Tropp S, Govil M, Granjeiro JM, Imoehl SR, Mansilla MA, Murray JC, Castilla EE, Orioli IM, Czeizel AE, Ma L, Chiquet BT, Hecht JT, Vieira AR, Marazita ML, Letra A, Menezes R, Cooper ME, Fonseca RF, Tropp S, Govil M, Granjeiro JM, Imoehl SR, Mansilla MA, Murray JC, Castilla EE, Orioli IM, Czeizel AE, Ma L, Chiquet BT, Hecht JT, Vieira AR, Marazita ML. CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population.
Shi J, Jiao X, Song T, Zhang B, Qin C, Cao F, Shi J, Jiao X, Song T, Zhang B, Qin C, Cao F. Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.
Carter TC, Molloy AM, Pangilinan F, Troendle JF, Kirke PN, Conley MR, Orr DJ, Earley M, McKiernan E, Lynn EC, Doyle A, Scott JM, Brody LC, Mills JL. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. CRISPLD2: a novel NSCLP candidate gene.
Chiquet BT, Lidral AC, Stal S, Mulliken JB, Moreno LM, Arcos-Burgos M, Valencia-Ramirez C, Blanton SH, Hecht JT, Chiquet BT, Lidral AC, Stal S, Mulliken JB, Moreno LM, Arcos-Burgos M, Valencia-Ramirez C, Blanton SH, Hecht JT. | 03/13/2008 |
| CRISPLD2 is expressed in the mandible, palate and nasopharynx regions during craniofacial development at E13.5-E17.5, respectively. Altogether, these data suggest that genetic variation in CRISPLD2 has a role in the etiology of NSCLP. | CRISPLD2: a novel NSCLP candidate gene.
Chiquet BT, Lidral AC, Stal S, Mulliken JB, Moreno LM, Arcos-Burgos M, Valencia-Ramirez C, Blanton SH, Hecht JT, Chiquet BT, Lidral AC, Stal S, Mulliken JB, Moreno LM, Arcos-Burgos M, Valencia-Ramirez C, Blanton SH, Hecht JT., Free PMC Articles: PMC3755375, PMC3755375 | 01/21/2010 |