| Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma. | Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.
Cai R, Gong X, Li X, Jiang Y, Deng S, Tang J, Ge H, Wu C, Tang H, Wang G, Xie L, Chen X, Hu X, Feng J., Free PMC Article | 03/13/2024 |
| Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4. | Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4.
Ulrich C, Canim Z, Herberger E, Girndt M, Fiedler R., Free PMC Article | 01/11/2024 |
| Structural insights into cytokine cleavage by inflammatory caspase-4. | Structural insights into cytokine cleavage by inflammatory caspase-4.
Devant P, Dong Y, Mintseris J, Ma W, Gygi SP, Wu H, Kagan JC., | 12/20/2023 |
| Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome. | Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome.
Kroken AR, Klein KA, Mitchell PS, Nieto V, Jedel EJ, Evans DJ, Fleiszig SMJ., Free PMC Article | 10/30/2023 |
| CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation. | CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation.
Rodrigues TS, Caetano CCS, de Sá KSG, Almeida L, Becerra A, Gonçalves AV, Lopes LS, Oliveira S, Mascarenhas DPA, Batah SS, Silva BM, Gomes GF, Castro R, Martins RB, Avila J, Frantz FG, Cunha TM, Arruda E, Cunha FQ, Nakaya H, Cunha LD, Fabro AT, Louzada-Junior P, de Oliveira RDR, Zamboni DS. | 06/16/2023 |
| Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis. | Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis.
Liu W, Li X, Ma Q, Zhu Y, Zhao W, Yang Y, Xiao W, Huang D, Cai F, Chan DYL, Zhao S, Chu Q., Free PMC Article | 06/14/2023 |
| CASP4 and CASP8 as newly defined autophagy-pyroptosis-related genes associated with clinical and prognostic features of renal cell carcinoma. | CASP4 and CASP8 as newly defined autophagy-pyroptosis-related genes associated with clinical and prognostic features of renal cell carcinoma.
Li T, Liu N, Zhang G, Chen M. | 01/21/2023 |
| Caspase-11/4 is involved in bacteria-mediated periodontitis by promoting the release of interleukin-1 beta and tumor necrosis factor-alpha. | Caspase-11/4 is involved in bacteria-mediated periodontitis by promoting the release of interleukin-1 β and tumor necrosis factor-α.
Li Z, Cai Q, Li B, Meng W. | 10/1/2022 |
| Caspase-4/11 is critical for angiogenesis by repressing Notch1 signalling via inhibiting gamma-secretase activity. | Caspase-4/11 is critical for angiogenesis by repressing Notch1 signalling via inhibiting γ-secretase activity.
Fan L, Liu H, Zhu G, Singh S, Yu Z, Wang S, Luo H, Liu S, Xu Y, Ge J, Jiang D, Pang J. | 10/1/2022 |
| Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells. | Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells.
Naseer N, Zhang J, Bauer R, Constant DA, Nice TJ, Brodsky IE, Rauch I, Shin S., Free PMC Article | 07/30/2022 |
| Expression of human caspase-4 in the gingival epithelium affected with periodontitis: Its involvement in Porphyromonas gingivalis-challenged gingival epithelial cells. | Expression of human caspase-4 in the gingival epithelium affected with periodontitis: Its involvement in Porphyromonas gingivalis-challenged gingival epithelial cells.
Kantrong N, Buranaphatthana W, Hormdee D, Suwannarong W, Chaichit R, Pattanaporn K, Klanrit P, Krisanaprakornkit S. | 06/25/2022 |
| Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. | Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.
Fernández-Duran I, Quintanilla A, Tarrats N, Birch J, Hari P, Millar FR, Lagnado AB, Smer-Barreto V, Muir M, Brunton VG, Passos JF, Acosta JC., Free PMC Article | 06/18/2022 |
| Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. | Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.
Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO., Free PMC Article | 05/28/2022 |
| Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress. | Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress.
Chukai Y, Ito G, Konno M, Sakata Y, Ozaki T. | 05/14/2022 |
| The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1beta secretion. | The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion.
Wang S, Moreau F, Chadee K., Free PMC Article | 04/9/2022 |
| Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis. | Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
Yuan C, Wu M, Xiao Q, Zhao W, Li H, Zhong Y, Zhao M, Li C, Li Y, Yang X., Free PMC Article | 03/26/2022 |
| The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli. | The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli.
Lindblad A, Johansson C, Persson K, Demirel I., Free PMC Article | 03/19/2022 |
| Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1beta converting enzyme. | Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β converting enzyme.
Devant P, Cao A, Kagan JC., Free PMC Article | 03/5/2022 |
| Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4. | Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4.
Meng J, Song X, Yan G, Wang H, Li H, Lou D., Free PMC Article | 12/11/2021 |
| Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility. | Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility.
Ye L, Li G, Goebel A, Raju AV, Kong F, Lv Y, Li K, Zhu Y, Raja S, He P, Li F, Mwangi SM, Hu W, Srinivasan S., Free PMC Article | 02/6/2021 |
| Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria. | Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.
Santos JC, Boucher D, Schneider LK, Demarco B, Dilucca M, Shkarina K, Heilig R, Chen KW, Lim RYH, Broz P., Free PMC Article | 09/5/2020 |
| GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.
Chen Q, Shi P, Wang Y, Zou D, Wu X, Wang D, Hu Q, Zou Y, Huang Z, Ren J, Lin Z, Gao X., Free PMC Article | 07/18/2020 |
| Suppressing caspase-4 reduces the cytoplasmic distribution of endogenous TDP-43 in cultured human neural cells. Primate-specific caspase-4-mediated cleavage of TDP-43 accounts for its cytoplasmic mislocalization in the primate brains. | Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains.
Yin P, Guo X, Yang W, Yan S, Yang S, Zhao T, Sun Q, Liu Y, Li S, Li XJ., Free PMC Article | 06/27/2020 |
| Data show that CASP4/caspase-11, the cytosolic receptor for bacterial endotoxin (lipopolysaccharide: LPS), enhances graft-versus-host disease (GVHD) severity. | Caspase-11 signaling enhances graft-versus-host disease.
Lu Y, Meng R, Wang X, Xu Y, Tang Y, Wu J, Xue Q, Yu S, Duan M, Shan D, Wang Q, Wang H, Billiar TR, Xiao X, Chen F, Lu B., Free PMC Article | 01/4/2020 |
| Knockdown of caspase-4/5 preserved human tubular epithelial cells from cell death and reduced the release of mature IL-1beta. | Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury.
Zhang Z, Shao X, Jiang N, Mou S, Gu L, Li S, Lin Q, He Y, Zhang M, Zhou W, Ni Z., Free PMC Article | 12/14/2019 |