| Expression and Regulatory Network Analysis of BICC1 for Aged Sca-1-Positive Bone Narrow Mesenchymal Stem Cells. | Expression and Regulatory Network Analysis of BICC1 for Aged Sca-1-Positive Bone Narrow Mesenchymal Stem Cells.
Liu Z, Ou C, Xiang S, Xie Q, Che S, Zhang D, Meng L, Liu Z, Zhang G, Wang Y, Huang Y, Zhang W, Deng Y., Free PMC Article | 07/2/2022 |
| Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex. | Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
Minegishi K, Rothé B, Komatsu KR, Ono H, Ikawa Y, Nishimura H, Katoh TA, Kajikawa E, Sai X, Miyashita E, Takaoka K, Bando K, Kiyonari H, Yamamoto T, Saito H, Constam DB, Hamada H., Free PMC Article | 07/24/2021 |
| Study finding that Bicc1 is required for normoglycemia implies that renal gluconeogenesis may be important to inhibit cyst formation. | Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex.
Leal-Esteban LC, Rothé B, Fortier S, Isenschmid M, Constam DB., Free PMC Article | 01/19/2019 |
| Polymerization is a novel disease-relevant mechanism both to stabilize Bicc1 and to present associated mRNAs in specific silencing platforms. | Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA.
Rothé B, Leal-Esteban L, Bernet F, Urfer S, Doerr N, Weimbs T, Iwaszkiewicz J, Constam DB., Free PMC Article | 12/5/2015 |
| discovered that loss of the Pkd1 gene product, polycystin-1 (PC1), whose mutation causes human autosomal dominant polycystic kidney disease (ADPKD), downregulates Bicc1 expression in vitro and in vivo | Loss of polycystin-1 inhibits Bicc1 expression during mouse development.
Lian P, Li A, Li Y, Liu H, Liang D, Hu B, Lin D, Jiang T, Moeckel G, Qin D, Wu G., Free PMC Article | 01/10/2015 |
| identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and suggest that it does so by regulating Pkd2 transcript levels | Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.
Mesner LD, Ray B, Hsu YH, Manichaikul A, Lum E, Bryda EC, Rich SS, Rosen CJ, Criqui MH, Allison M, Budoff MJ, Clemens TL, Farber CR, Mesner LD, Ray B, Hsu YH, Manichaikul A, Lum E, Bryda EC, Rich SS, Rosen CJ, Criqui MH, Allison M, Budoff MJ, Clemens TL, Farber CR., Free PMC Articles: PMC4038574, PMC4038574 | 08/23/2014 |
| Bicc1 similarly induces silencing of the protein kinase inhibitor PKIalpha by miR-27a. | Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
Piazzon N, Maisonneuve C, Guilleret I, Rotman S, Constam DB, Piazzon N, Maisonneuve C, Guilleret I, Rotman S, Constam DB. | 05/3/2014 |
| Bicc1 is a novel regulator of osteoblastogenesis and bone mineral density (BMD) | Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.
Mesner LD, Ray B, Hsu YH, Manichaikul A, Lum E, Bryda EC, Rich SS, Rosen CJ, Criqui MH, Allison M, Budoff MJ, Clemens TL, Farber CR, Mesner LD, Ray B, Hsu YH, Manichaikul A, Lum E, Bryda EC, Rich SS, Rosen CJ, Criqui MH, Allison M, Budoff MJ, Clemens TL, Farber CR., Free PMC Articles: PMC4038574, PMC4038574 | 05/12/2014 |
| Bicc1 KH domains bind the 3' UTRs of AC6 and PKIa mRNAs and cognate miRNA precursors, whereas the SAM domain loads a silencing complex with AGO2. AC6 and PKIa protein levels increase in cystic Bicc1-/- mouse kidneys. | Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
Piazzon N, Maisonneuve C, Guilleret I, Rotman S, Constam DB, Piazzon N, Maisonneuve C, Guilleret I, Rotman S, Constam DB. | 06/27/2012 |
| lack of Bicc1 leads to disruption of normal cell-cell junctions. | Loss of Bicc1 impairs tubulomorphogenesis of cultured IMCD cells by disrupting E-cadherin-based cell-cell adhesion.
Fu Y, Kim I, Lian P, Li A, Zhou L, Li C, Liang D, Coffey RJ, Ma J, Zhao P, Zhan Q, Wu G., Free PMC Article | 07/12/2010 |
| Data suggest that Bicc1 functions by modulating the expression of polycystin 2 (Pkd2 by antagonizing the repressive activity of the miR-17 microRNA family on the 3'UTR of Pkd2 mRNA. | The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity.
Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O., Free PMC Article | 04/12/2010 |
| Data report that targeted inactivation of BicC randomizes left-right asymmetry by disrupting the planar alignment of motile cilia required for cilia-driven fluid flow, and that BicC can uncouple Dvl2 signaling from the canonical Wnt pathway. | Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow.
Maisonneuve C, Guilleret I, Vick P, Weber T, Andre P, Beyer T, Blum M, Constam DB. | 01/21/2010 |
| Bicc1 and SamCystin interact at the protein level suggesting that they function in a common molecular pathway that when perturbed, is involved in cystogenesis. | The polycystic kidney disease-related proteins Bicc1 and SamCystin interact.
Stagner EE, Bouvrette DJ, Cheng J, Bryda EC. | 01/21/2010 |
| Binds homoribopolymers in vitro; the third K homology domain is necessary and sufficient for in vitro Bicc1 RNA binding. | K homology domains of the mouse polycystic kidney disease-related protein, Bicaudal-C (Bicc1), mediate RNA binding in vitro.
Bouvrette DJ, Price SJ, Bryda EC. | 01/21/2010 |